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posted by martyb on Wednesday January 27 2016, @03:36PM   Printer-friendly
from the avoid-the-amateur-biotics dept.

The "good bacteria," or probiotics, that fill the pomegranate drink are everywhere these days, in pills and powders marketed as super supplements. Probiotics are said to improve digestive and immune health. They're touted as potential treatments for conditions ranging from inflammatory bowel disease to eczema to tooth decay. Some marketing campaigns even hint that they can prevent the flu.

Scientific evidence, however, does not necessarily support those claims.

Studies in rodents and small groups of humans point to possible health benefits of consuming probiotics. But there have been only a few large human trials — in large part because Food and Drug Administration rules have dissuaded food companies and federally funded researchers from conducting the types of studies that could confirm, or refute, the proposed benefits of consuming "good" microbes.

http://www.statnews.com/2016/01/21/probiotics-shaky-science/


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  • (Score: 0) by Anonymous Coward on Wednesday January 27 2016, @04:32PM

    by Anonymous Coward on Wednesday January 27 2016, @04:32PM (#295383)

    So I figured WTH I would give one of these probiotic diets a try. I knew it would not do much I was just being a goof.

    2 bottles of pills that did nothing. The real 'diet' was in the paperwork that came with it. "stop eating sugar for 1 month". Ah I see they are trying to tie the pills to the weight loss but the real weight loss comes from less carbs.

    Tossed out the remainder of the pills. Doing lower sugar, lower carb and more exercise, then I lost weight. Who would have guessed.

  • (Score: 2) by ikanreed on Wednesday January 27 2016, @04:44PM

    by ikanreed (3164) Subscriber Badge on Wednesday January 27 2016, @04:44PM (#295393) Journal

    And low carb is, itself, only an easy mental wrapper on the general function of eating fewer calories. You see a lot of claims about ketosis and how it causes weight loss, but these effects tend to be marginal compared to the calorie-cutting effect.

    Carbs are an easy way to get a lot of calories fast, only pure oils and fats are faster. And unlike oils and fats, normal carb consumption includes eating them in near pure form.

    Once you cut out carbs like bread, rice, potatoes, and sugar, the remaining options are either low-calorie or meat.

    • (Score: 1, Insightful) by Anonymous Coward on Wednesday January 27 2016, @04:54PM

      by Anonymous Coward on Wednesday January 27 2016, @04:54PM (#295399)

      That was sort of my point. It was basically a low carb diet. Not a 'pill' diet. Like I said I was being a goof and doing a 'wth' trial. I knew it would not work.

      Once you cut out carbs like bread, rice, potatoes, and sugar, the remaining options are either low-calorie or meat.
      Very good points. Another one I would like to make is 1 calorie of sugar is not the same as 1 calorie of meat. Your body will snork up the sugar quickly. The meat takes time for you to digest and by the time it is at the intake level it is much less than 1 calorie. The way a calorie is calculated is sort of misleading. We basically set something on fire and boil water then measure the time. It is a 'good' correlation but a rather imperfect one.

      Also many people do not do much credence to the relation of weight vs age. As you age your body changes. Its ability to process food changes. Also your activity levels may change too. You need to keep that in mind. This does not hold true in all cases but it is there. For example in my family in their late 40s to mid 50s weight gain becomes an issue. Up until then they are relativity skinny. So finding a good diet does mean rolling with changes as you age too.

      • (Score: 2) by ikanreed on Wednesday January 27 2016, @04:57PM

        by ikanreed (3164) Subscriber Badge on Wednesday January 27 2016, @04:57PM (#295401) Journal

        Glycemic index is indeed a thing, but it's not particularly important to weight-loss. It can matter a fuck-ton if you're a diabetic.

        • (Score: 2) by VLM on Wednesday January 27 2016, @05:47PM

          by VLM (445) Subscriber Badge on Wednesday January 27 2016, @05:47PM (#295429)

          with everyone being fat and diabetic or pre-diabetic, doesn't that boil down to "everyone" anyway? Its not like low GI foods would impair a skinny athlete anyway.

      • (Score: 2) by VLM on Wednesday January 27 2016, @05:56PM

        by VLM (445) Subscriber Badge on Wednesday January 27 2016, @05:56PM (#295434)

        Its ability to process food changes. Also your activity levels may change too.

        I've noticed this with my own low carb experiments, where crap tier food like a stereotypical thanksgiving dinner with 500 grams of carbs minimum makes me feel tired but a nice low carb meal and I've got tons of energy.

        You starve yourself on a high carb diet and you feel starved, exhausted, lay on couch and watch TV.. get fat. You starve yourself on low carb diet and feel like you drank an extra cup of tea, go out hiking, take the kids to the park and run around.. get thin. Then some dude tells you "its just calories in equals calories out" yeah sure, but there's this slight subjective difference, like the difference between feeling like a refugee looks vs feeling ten years younger, as if that has no impact on the likelihood of the diet's long term success.

        • (Score: 0) by Anonymous Coward on Wednesday January 27 2016, @07:27PM

          by Anonymous Coward on Wednesday January 27 2016, @07:27PM (#295489)

          A chunk of carbon probably has a very high calorie number. However, my bodies absorption of it is probably very low.

          My wildly wrong point is I personally use calorie as a rough gauge of what is going on. Next stop is the carbs. Next stop after that is the ingredient list. What ticks me off to no end is the number of different names for sugar and the substitutes that are equivalent to sugar.

          If you come across something where 1 serving is 1500 calories. Something is going on (probably not good). The devil is in the details. Also the dosage makes the poison. It is sort of like smoking. 1 cigarette is not going to instantly give you stage 3 lung cancer. 2 packs a day every day for 25 years probably will.

          And tonight I am eating at 5 guys. I am a sucker for good fries (damn you potato sugar carbs!!! :) ).

    • (Score: 2) by legont on Thursday January 28 2016, @05:41AM

      by legont (4179) on Thursday January 28 2016, @05:41AM (#295788)

      True, but not exactly.

      First, carbs promote overeating. One gets hungry again very soon after say rice or potatoes, while fat takes more time to digest. For me it is almost impossible to overeat meat.

      Second, one can eat say lean chicken, non-fat greek yoghurt and so on bringing down animal fat intake - the biggest argument against Atkins.

      Third, whatever calorie deficit is easily replaced by better fats - nuts, avocado, olive oil.

      The bottom line, it's much easier to cut carbs than to keep so called low calorie balanced diet.

      Besides, most carb foods are carcinogenic, especially whole bread, fries, cookies - basically anything starchy cooked at high temps (acrylamide is known to cause cancer or reproductive toxicity in the state of California:)

      Oh, and speaking of reproductive, carbs at night bring testosterone way way down.

      Government or doctors on the other hand will never recommend it simply because there are not enough food out there without carbs.

      --
      "Wealth is the relentless enemy of understanding" - John Kenneth Galbraith.
      • (Score: 0) by Anonymous Coward on Thursday January 28 2016, @06:10AM

        by Anonymous Coward on Thursday January 28 2016, @06:10AM (#295800)

        "One gets hungry again very soon after say rice or potatoes [...]"

        In a study that measured the satiating index of 38 foods, including brown rice and whole-wheat bread, people ranked boiled potatoes highest, reporting that they felt fuller and ate less two hours after consuming them.

        https://abcnews.go.com/Health/10-filling-foods-weight-loss/story?id=21153507 [go.com]

  • (Score: 3, Informative) by takyon on Wednesday January 27 2016, @04:59PM

    by takyon (881) <reversethis-{gro ... s} {ta} {noykat}> on Wednesday January 27 2016, @04:59PM (#295405) Journal

    I associated probiotics not with pills but with kombucha, sauerkraut/kimchi, and yogurt. You know, products with billions of bacteria floating around in them.

    Does eating Lactobacillus colonized foods help you? Maybe. But many yogurt products have a ton of added sugar.

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    • (Score: 2) by quixote on Wednesday January 27 2016, @08:23PM

      by quixote (4355) on Wednesday January 27 2016, @08:23PM (#295532)

      If they aren't, you have bigger problems than bad bacterial flora in your large intestine.

      What affects the ecology of bacteria in the colon is the contents of the colon. That's composed of undigested food such as different kinds of fiber, the breakdown products of digestion, digestive acids from the liver, breakdown products from the bacteria living there, and so on.

      The reason yoghurt and sauerkraut and fibrous food help is not because of the bacteria they contain. Those (you hope!) got killed in the stomach. They help because by the time you've finished digesting them, what's passing through the large intestine is conducive to the growth of bacteria associated with good health.

      Changing diet can change intestinal ecology drastically, so, yes, what you eat matters for that. But not in the sense that eating, say, Lactobacillus acidophilus somehow makes it all the way to the colon and starts a "good" colony.

      It is possible to introduce specific strains of bacteria to the colon, but it's done from the other end and is called a fecal transplant. And, yes, there's very interesting research coming out showing that changing intestinal ecology can have far-reaching effects on health and disease.

      • (Score: 2) by takyon on Wednesday January 27 2016, @08:36PM

        by takyon (881) <reversethis-{gro ... s} {ta} {noykat}> on Wednesday January 27 2016, @08:36PM (#295536) Journal

        Are you sure Lactobacillus can't survive the stomach? They do excrete acid after all.

        Well, I looked it up and it turns out THEY CAN:

        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489325/ [nih.gov]

        Whether Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus can be recovered after passage through the human gut was tested by feeding 20 healthy volunteers commercial yogurt. Yogurt bacteria were found in human feces, suggesting that they can survive transit in the gastrointestinal tract.

        http://ajcn.nutrition.org/content/73/2/399s.full [nutrition.org]

        Bifidobacteria and lactobacilli are purportedly beneficial to human health and are called probiotics. Their survival during passage through the human gut, when administered in fermented milk products, has been investigated intensely in recent years. Well-controlled, small-scale studies on diarrhea in both adults and infants have shown that probiotics are beneficial and that they survive in sufficient numbers to affect gut microbial metabolism. Survival rates have been estimated at 20–40% for selected strains, the main obstacles to survival being gastric acidity and the action of bile salts. Although it is believed that the maximum probiotic effect can be achieved if the organisms adhere to intestinal mucosal cells, there is no evidence that exogenously administered probiotics do adhere to the mucosal cells. Instead, they seem to pass into the feces without having adhered or multiplied. Thus, to obtain a continuous exogenous probiotic effect, the probiotic culture must be ingested continually.

        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1151822/ [nih.gov]

        Probiotics must survive in the acidic gastric environment if they are to reach the small intestine and colonize the host, thereby imparting their benefits. Lactobacillus species are considered intrinsically resistant to acid (51).

        [...] The increased survival of probiotic lactobacilli in acidic conditions in the presence of glucose has been reported previously (7). However, the mechanisms involved were not studied. In addition, it has been reported that lactic acid bacteria are capable of metabolizing glucose at low pH, albeit at lower rates (29, 54). The aims of this study were to evaluate the effect of glucose on L. rhamnosus GG survival in simulated gastric juice, to compare the protective effect of glucose on L. rhamnosus GG survival at low pH with that for other probiotic lactobacilli, and to elucidate the mechanisms responsible for the protective effect of glucose in acidic conditions.

        See bolded portion and compare to:

        The reason yoghurt and sauerkraut and fibrous food help is not because of the bacteria they contain. Those (you hope!) got killed in the stomach.

        I was about to say that effects could be seen before anything reaches the stomach. For example, bacteria in the mouth affect tooth decay, and tooth decay is linked with heart disease (I'm not sure about the causality).

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        • (Score: 0) by Anonymous Coward on Wednesday January 27 2016, @09:33PM

          by Anonymous Coward on Wednesday January 27 2016, @09:33PM (#295578)

          Just because some bacteria is good for your gut doesn't mean it's also good for your teeth.

          • (Score: 2) by takyon on Wednesday January 27 2016, @09:56PM

            by takyon (881) <reversethis-{gro ... s} {ta} {noykat}> on Wednesday January 27 2016, @09:56PM (#295588) Journal

            Every part of your body has different kinds of bacteria living on it. The microbiome is necessarily a complex subject

            It means that the introduction of certain bacteria could be considered an oral health treatment.

            On the subject of bacteria good for your gut being good for your teeth, I found this:

            http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897872/ [nih.gov]

            Several studies suggest that consumption of products containing probiotic lactobacilli or bifidobacteria could reduce the number of mutans streptococci in saliva.32–40 The tendency toward a decreased number of mutans streptococci in the saliva seems to be independent of the product or strain used; however, such effect has not been observed in all studies.41 The discrepancies between results cannot be explained by only the use of different probiotic strains, as different results have also been obtained using the same strains.

            [...] The first studies of the use of probiotics for enhancing oral health were for the treatment of periodontal inflammation.43 Patients with various periodontal diseases, gingivitis, periodontitis, and pregnancy gingivitis, were locally treated with a culture supernatant of a L. acidophilus strain. Significant recovery was reported for almost every patient. There has been significant interest in using probiotics in treatment of periodontal disease recently, too. The probiotic strains used in these studies include L. reuteri strains, L. brevis (CD2), L. casei Shirota, L. salivarius WB21, and Bacillus subtilis. L. reuteri and L. brevis have improved gingival health, as measured by decreased gum bleeding.

            [...] The interest in oral probiotics has been growing during the last decades. Most of the studies have been conducted with probiotic strains originally suggested for gut health; however, it is important to realize that each of the suggested health benefits should be studied for each bacterial strain individually. Thus, a probiotic bacterium in the mouth is not necessarily an oral probiotic. Furthermore, it is quite possible that the same species are not optimal for all oral health purposes; e.g., different properties might be desired in respect to dental and gingival health.

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        • (Score: 2) by quixote on Friday January 29 2016, @11:18PM

          by quixote (4355) on Friday January 29 2016, @11:18PM (#296749)

          Interesting! And good news for those of us trying to improve our large intestine bacteria.

          It is still true, though, that the largest effect on those bacteria is the environment they're given. If your diet is meat+sugar, just as an extreme example, the occasional dose of probiotics won't help much. If you have one of those healthy Mediterranean diets they're always on about, you'd be very likely to have good intestinal flora without any added probiotics. (Although yoghurt is or can be part of that diet, so there's that.)

          Anyway, cool to learn something new with good links to sources. :D

    • (Score: 0) by Anonymous Coward on Thursday January 28 2016, @09:41AM

      by Anonymous Coward on Thursday January 28 2016, @09:41AM (#295859)

      I associated probiotics not with pills but with kombucha, sauerkraut/kimchi, and yogurt. You know, products with billions of bacteria floating around in them.

      Yup, thought the pills were just for emergencies

      Does eating Lactobacillus colonized foods help you? Maybe. But many yogurt products have a ton of added sugar.

      It is practically impossible to get good food off the shelf these days. The latest generation of food scientists and actuary run businesses have made sure of that. Most cultured food is ridiculously easy to make at home and isn't very time consuming, can fit into any lifestyle.

      Check out a book by Sandor Katz. The man is a genius.

  • (Score: 0) by Anonymous Coward on Wednesday January 27 2016, @06:05PM

    by Anonymous Coward on Wednesday January 27 2016, @06:05PM (#295442)

    So I figured WTH I would give one of these probiotic diets a try.

    If you are interested in inclusion of more probiotics in your diet then I would recommend eating more yogurt. Other good sources of probiotics include raw apple cider vinegar, sauerkraut, and pickles. No need to be "a goof" about this.

    • (Score: 0) by Anonymous Coward on Thursday January 28 2016, @06:14AM

      by Anonymous Coward on Thursday January 28 2016, @06:14AM (#295803)

      Pickles from the supermarket aren't fermented, are they (I know you didn't say "from the supermarket")?

  • (Score: 2) by SubiculumHammer on Wednesday January 27 2016, @07:15PM

    by SubiculumHammer (5191) on Wednesday January 27 2016, @07:15PM (#295469)

    Here is the idea. Gut bacteria of a certain type like certain types of food. Other types like other types of food. Some break down sugars, others fiber, and so on. If you eat poorly (McDonalds) then you are selecting bacteria of certain types. But there is potentially a feed back loop. There are nerve receptors in the gut that signal reward centers in the brain, and gut bacteria produce a number of known neurotransmitters in their life-cycles, which may influence activity in the brain in reward centers.

    A reasonable hypothesis then is that biotics in the gut would have a selective advantage if they could convince the host to eat foods that it prefers. If your diet tends to be laden with fats and sugars, then you are selecting a monoculture of fat and sugar digesting microbes, whom then produce neurotransmitters that activate reward centers for eating fats and sugars. However, those microbes that process vegetable fibers should have a similar interests in manipulating host eating behaviors to eat more vegetable fibers...but if you have a mcdonalds mnoculture of microbes the vegetable fiber microbes can not control the host effectively. On the other hand, if you have a balanced diet, or a balanced population of microbes, no single group can effectively manipulate your eating behaviors to their particular advantage.

    I can't find the review paper right now that this cam from....but it is a fascinating hypothesis.