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Do you have low T, bro? It may be affecting your "mood":
As men age, they lose testosterone — which some say affects their sense of well-being and sexual function. But for healthy older men, using supplemental testosterone as a remedy has been controversial. Past studies of the supplement's use have been relatively small, and the evidence about benefits and risks has been mixed.
Now a well-designed study published [open, DOI: 10.1056/NEJMoa1506119] online Wednesday, in the New England Journal of Medicine, confirms certain benefits in sexual function and mood for some men 65 and over, at least in the first year. Though the gains were modest, and some tended to wane in the latter months of treatment, researchers say the findings are encouraging, and merit further research.
[...] The University of Pittsburgh was one of 12 sites nationwide that collaborated to look at the possible benefits of testosterone in older men whose levels of the hormone were below 275 ng per deciliter of blood — that's just below the wide range that many doctors consider "normal" for healthy, younger men.
The scientists screened more than 51,000 men who were 65 or older for their study, and from that group found 790 with low testosterone, as measured by a blood test. The researchers say the study wasn't designed to get at whether the men had lost the hormone more rapidly than others, or whether they produced less testosterone to begin with. About half the participants were given testosterone gel, and the other half a placebo gel. Until the first year of the study was over, neither the participants nor the researchers knew which men were getting the placebo.
"The testosterone concentrations in the men in this trial [who got the active treatment] were increased, on average, to just the middle of the normal range for young men," says endocrinologist Dr. Peter Snyder, of the University of Pennsylvania, who led the study. After a year, Snyder says, though the benefits were only moderate, it was clear that mood and physical activity had improved among the group that had been getting a boost of testosterone. And the biggest improvement, he says, was in sexual function. "Testosterone improved sexual activity, sexual desire and improved erectile function," Snyder says.
[...] Past research has suggested that increasing testosterone levels might also increase the risk for of heart attack and stroke, or lead to prostate issues. But Snyder says, so far, his team of scientists has found no increase in adverse events among those taking the hormone. Still, that doesn't mean testosterone supplements are safe to take long-term, he says. To get those answers, he says, far more research is needed — larger studies that last longer periods of time.
Bonus article: Sound wave therapy is first alternative to Vîagra in 15 years
(Score: 5, Interesting) by maxwell demon on Thursday February 18 2016, @10:35AM
Anyone remembers that giving oestrogen was considered to be good for women in the menopause? Well, until they found that it actually did more harm than good. I suspect the testosterone for old men is the same (actually, one could argue that too much of it is already harmful for young men :-)).
But there's of course much to earn by selling testosterone to healthy old men.
And BTW, the authors obviously are of the opinion that stronger sexual desire is necessarily better. I don't see why this should be the case. Indeed, I can imagine that for those who cannot get it fulfilled, a stronger sexual desire would actually be detrimental.
The Tao of math: The numbers you can count are not the real numbers.
(Score: 2) by patella.whack on Thursday February 18 2016, @10:51AM
out of mod pts.. +1
(Score: 5, Funny) by inertnet on Thursday February 18 2016, @10:52AM
Not to worry, younger women with their skirts up can easily outrun older men on testosterone with their pants down.
(Score: 3, Informative) by gnuman on Thursday February 18 2016, @09:25PM
Not to worry, younger women with their skirts up can easily outrun older men on testosterone with their pants down.
That explains the kilt.
(Score: 0, Flamebait) by patella.whack on Thursday February 18 2016, @11:25AM
Well, you are possibly right given your outdated information, but providing estrogen to menopausal women is not analagous to providing testosterone to men. Your assumption has no basis in fact although it is fun in a childlike storytelling narrative.
(Score: 3, Interesting) by bzipitidoo on Thursday February 18 2016, @03:53PM
Not analogous? Our entire medical system is warped by greed. I'm not saying that doctors are more interested in money than the good health of their patients, though some are of course. The "fee for service" system hangs over everyone, influencing decisions both consciously and unconsciously.
The "Hormone Replacement Therapy" craze of the late 90s, for older women only, was definitely driven by greed. In their eagerness to rush the treatment out and start making money, Big Pharma got reckless, minimized the problems. The Fountain of Youth beckoned; the public got youth dangled like a carrot in front of us. The idea that forcing one symptom of aging to return to levels seen in younger people would somehow push the body back towards youth and not throw the entire bodily system for a loop seems very doubtful. It's one thing to correct abnormal levels, it's quite another to declare that levels normal for the old should be changed, and the manner in which to achieve the change is the highly interventionist magic pill that must be taken daily for the rest of life. Sure sells a whole lot more pills, as far more people qualify as normal than abnormal on measures of any specific hormone levels. In 2002 reports of more problems came out, HRT's reputation plummeted, and most women quit.
Now this report comes out, and within hours, the schemes to push more pills based on it, an HRT for older men, are undoubtedly in the works. They will have to rehabilitate the name or come up with another, of course. Other methods for raising testosterone, if that is indeed a good idea, will be ignored if they involve a smaller or no transfer of wealth from patients to Big Pharma.
(Score: 2) by patella.whack on Thursday February 18 2016, @04:17PM
I'd like to remove this comment!.. of course it's not possible, so in the vein of an ethanol fueled commentary, i'll just ask the judge to strike it from the record.
-cheers
(Score: 0) by Anonymous Coward on Thursday February 18 2016, @01:34PM
After a certain age, nature (and Darwin) stops caring about people... it's every man or woman for themself.
(Score: 2, Funny) by OrugTor on Thursday February 18 2016, @04:42PM
The sexual desire thing was what struck me too. As an older man I am thankful that I don't have to do deal with the curse of the male libido any more (mostly). Also bear in mind that except for the 1%, older men are typically married to older women. You don't want to think about Gramps having sex? Neither does Gramps.