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from the the-best-made-plans-of-mice-and-men... dept.
The human embryo editing study first reported by MIT Technology Review last week has been published in Nature. Scientists led by the Oregon Health & Science University's Shoukhrat Mitalipov edited human embryos to remove the MYBPC3 mutation associated with hypertrophic cardiomyopathy:
The experiment corrected the defect in nearly two-thirds of several dozen embryos, without causing potentially dangerous mutations elsewhere in the DNA.
None of the embryos were used to try to create a baby. But if future experiments confirm the techniques are safe and effective, the scientists say the same approach could be used to prevent a long list of inheritable diseases. "Potentially, we're talking about thousands of genes and thousands of patients," says Paula Amato, an associate professor of obstetrics and gynecology at Oregon Health & Science University in Portland. She was a member of the scientific team from the U.S., China and South Korea.
[...] Amato and others stress that their work is aimed at preventing terrible diseases, not creating genetically enhanced people. And they note that much more research is needed to confirm the technique is safe and effective before anyone tries to make a baby this way. But scientists hoping to continue the work in the U.S. face many regulatory obstacles. The National Institutes of Health will not fund any research involving human embryos (the new work was funded by Oregon Health & Science University). And the Food and Drug Administration is prohibited by Congress from considering any experiments that involve genetically modified human embryos.
Nevertheless, the researchers say they're hopeful about continuing the work, perhaps in Britain. The United Kingdom has permitted genetic experiments involving human embryos forbidden in the United States. "If other countries would be interested, we would be happy to work with their regulatory bodies," says Shoukhrat Mitalipov, director of the Oregon Health & Science University's Center for Embryonic Cell and Gene Therapy.
Also at NYT, MIT, BBC, Science Magazine, and Scientific American.
Correction of a pathogenic gene mutation in human embryos (open, DOI: 10.1038/nature23305) (DX)
Previously: First Known Attempt at Genetically Modifying Human Embryos in the U.S. is an Apparent Success
(Score: 0) by Anonymous Coward on Thursday August 03 2017, @11:31PM (2 children)
Anyone know if this is covered under the embryonic stem cell research ban of the Bush years?
From what I can remember, scientists can't use any equipment or personal that were bought or funded and with federal money. Labs that did this kind of research had to buy two of everything as indirect federal funding of these projects would result in their grant money being taken away.
(Score: 3, Informative) by takyon on Thursday August 03 2017, @11:52PM
https://en.wikipedia.org/wiki/Stem_cell_laws_and_policy_in_the_United_States [wikipedia.org]
There was no "embryonic stem cell research ban". Federal funding was restricted to an existing number of cell lines. Bush vetoed attempts to expand this in 2006. You could still do your research, but you could not get federal funding for it. Most restrictions were lifted by Obama, but there was still this:
Francis Collins, who still leads NIH, will not fund germline modification [soylentnews.org], which this is. NYT confirms the funding sources:
[SIG] 10/28/2017: Soylent Upgrade v14 [soylentnews.org]
(Score: 4, Insightful) by driverless on Friday August 04 2017, @02:56AM
To see where this is really heading, all you need to do is change one letter: