Vitamin C was determined by high-performance liquid chromatography with photodiode detector (detection limit 1.5 mg/L). Vitamin C reference values in general population used to be above 5 mg/L. Seventeen paients (94.4%) had undetectable vitamin C levels and 1 patient had low levels (2.4 mg/L).
To our knowledge, this is the first study to analyze the levels of vitamin C in patients with SARS-CoV-2-associated ARDS. Our study revealed that vitamin C levels are undetectable in more than 90% of the patients included.
https://pubmed.ncbi.nlm.nih.gov/32847620/ [nih.gov]