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posted by martyb on Friday March 11 2016, @03:46PM   Printer-friendly
from the hard-to-take dept.

Two Soylentils wrote in about the failure of the United States' first attempted uterus transplant:

Uterine Transplant Fails

The Cleveland Clinic, in Cleveland, Ohio, has embarked upon a programme of uterine transplantation, with surgeries planned on a total of ten patients. The first recipient, however, has suffered an unspecified "sudden complication" and the transplanted uterus, which was obtained from a cadaver, has been removed.

The first uterine transplant, which was unsuccessful, was performed in 1931. This was the first time the procedure had been attempted in the United States, where it is still considered experimental.



First Uterus Transplant in the U.S. Fails After Complication

The first ever attempted uterus transplant in the U.S. has failed after an unknown complication occurred:

The Cleveland Clinic says it has removed a transplanted uterus — the first-ever in the U.S. — after the patient suffered from a "sudden complication."

The clinic conducted the landmark operation in late February. As we reported, the procedure is intended to "open up another possible path to parenthood besides surrogacy or adoption for U.S. women who do not have a uterus, or who have a uterus that does not function."

The transplant was part of a study that the clinic says is meant to include 10 women with uterine factor infertility, meaning "they were born without a uterus, have lost their uterus, or have a uterus that no longer functions." The clinic says in a statement that the study will continue despite this setback.

The risky procedure takes into account the chance of the body rejecting the organ by including the administration of anti-rejection drugs throughout the years following the surgery as well as monthly cervical biopsies to check for organ rejection. In vitro fertilization is used to create embryos that will be implanted in the uterus. The transplant is intended to be temporary, and after the successful childbirth of one or two babies the transplanted uterus is either removed by a hysterectomy or allowed to disintegrate. Nine uterus transplants have taken place in Sweden, resulting in 5 pregnancies and 4 births.

Study about the first ever live birth following a uterus transplant: Livebirth after uterus transplantation (DOI: 10.1016/S0140-6736(14)61728-1)

Original Submission #1Original Submission #2

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  • (Score: 2) by takyon on Friday March 11 2016, @09:04PM

    by takyon (881) <reversethis-{gro ... s} {ta} {noykat}> on Friday March 11 2016, @09:04PM (#317158) Journal

    Eventually we will post a story about growing a new (longer) penis or a uterus from your own stem cells, for the purpose of transplantation.

    And someone will comment "waaah fertility research is a waste of money! only the rich benefit!!11". There's no pleasing the crowd.

    As for the testes thing, the penis transplant guy I heard of fathered his own child, so testes weren't involved. I doubt that a donor testicle transplant would even work, or would keep producing another man's sperm. That would be funny though.

    This uterus transplant technique would be greatly enhanced by lab-grown organs. It's not like these transplant are going to routinely fail because of surgical complications. It's the rejection and need for anti-rejection drugs that is the main obstacle, and yet women have still had children with these temporary uteruses.

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  • (Score: 2) by butthurt on Friday March 11 2016, @10:42PM

    by butthurt (6141) on Friday March 11 2016, @10:42PM (#317211) Journal

    I found a Web page about testicular transplantation []. It says the first (unsuccessful) attempt on a human was in 1911, then the procedure became widespread in the 1920s, with questionable results, and really took off when a doctor named Serge Voronoff [] started implanting bits of testicular tissue from chimpanzees into humans. For some reason [], the surgery fell out of favour []. Then in 1977, a testicular transplant was done between identical twins by someone called Sherman Silber [], and resulted in four children. Wikipedia erroneously credits Silber with "the world's first ovary and testicle transplants."