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First Uterus Transplant in the U.S. Fails After Complication

Accepted submission by takyon at 2016-03-10 17:28:46
Science

The first ever attempted uterus transplant [wikipedia.org] in the U.S. has failed after an unknown complication occurred [npr.org]:

The Cleveland Clinic says it has removed a transplanted uterus — the first-ever in the U.S. — after the patient suffered from a "sudden complication."

The clinic conducted the landmark operation in late February. As we reported [npr.org], the procedure is intended to "open up another possible path to parenthood besides surrogacy or adoption for U.S. women who do not have a uterus, or who have a uterus that does not function."

The transplant was part of a study that the clinic says is meant to include 10 women [clevelandclinic.org] with uterine factor infertility, meaning "they were born without a uterus, have lost their uterus, or have a uterus that no longer functions." The clinic says in a statement [clevelandclinic.org] that the study will continue despite this setback.

The risky procedure [clevelandclinic.org] takes into account the chance of the body rejecting the organ by including the administration of anti-rejection drugs throughout the years following the surgery as well as monthly cervical biopsies to check for organ rejection. In vitro fertilization is used to create embryos that will be implanted in the uterus. The transplant is intended to be temporary, and after the successful childbirth of one or two babies the transplanted uterus is either removed by a hysterectomy or allowed to disintegrate. 9 uterus transplants have taken place in Sweden, resulting in 5 pregnancies and 4 births.

Study about the first ever live birth following a uterus transplant: Livebirth after uterus transplantation [thelancet.com] (DOI: 10.1016/S0140-6736(14)61728-1)


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