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posted by martyb on Sunday May 17 2020, @04:17PM   Printer-friendly
from the getting-closer dept.

From the latest blog post of Derek Lowe :

One of the big (and so far unanswered) questions about the coronavirus epidemic is what kind of immunity people have after becoming infected. This is important for the idea of “re-infection” (is it even possible?) and of course for vaccine development. We’re getting more and more information in this area, though, and this new paper is a good example. A team from the La Jolla Institute for Immunology, UNC, UCSD, and Mt. Sinai (NY) reports details about the T cells of people who have recovered from the virus.

[...] So overall, this paper makes the prospects for a vaccine look good: there is indeed a robust response by the adaptive immune system, to several coronavirus proteins. And vaccine developers will want to think about adding in some of the other antigens mentioned in this paper, in addition to the Spike antigens that have been the focus thus far. It seems fair to say, though, that the first wave of vaccines will likely be Spike-o-centric, and later vaccines might have these other antigens included in the mix. But it also seems that Spike-protein-targeted vaccines should be pretty effective, so that’s good. The other good news is that this team looked for the signs of an antibody-dependent-enhancement response, which would be bad news, and did not find evidence of it in the recovering patients (I didn’t go into these details, but wanted to mention that finding, which is quite reassuring). And it also looks like the prospects for (reasonably) lasting immunity after infection (or after vaccination) are good. This, from what I can see, is just the sort of response that you’d want to see for that to be the case. Clinical data will be the real decider on that, but there’s no reason so far to think that a person won’t have such immunity if they fit this profile.

Onward from here, then – there will be more studies like this coming, but this is a good, solid look into the human immunology of this outbreak. And so far, so good.

Be sure to read the article if you’ve been wondering what your thymus has done for you lately.

Journal Reference
Alba Grifoni, Daniela Weiskopf. Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals, Cell (DOI: 10.1016/j.cell.2020.05.015)


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  • (Score: 2) by Azuma Hazuki on Monday May 18 2020, @01:35PM (13 children)

    by Azuma Hazuki (5086) on Monday May 18 2020, @01:35PM (#995749) Journal

    Sounds like *socialism* ta me, boy..whah duh yew hayt uh-merrika?

    --
    I am "that girl" your mother warned you about...
    Starting Score:    1  point
    Karma-Bonus Modifier   +1  

    Total Score:   2  
  • (Score: 2, Disagree) by Reziac on Monday May 18 2020, @02:03PM (12 children)

    by Reziac (2489) on Monday May 18 2020, @02:03PM (#995766) Homepage

    Socialism is when you don't have a choice, you participate or else. Socialism only 'works' when there's a man with a gun to enforce participation.

    No one forced us to line up for flu vaccine; we merely observed that flu was worse than an hour in line on a subzero night. No one forced county health to juggle numbers and decide vaccine was cheaper than disease. In both cases it was purely enlightened self-interest, for which we were willing to spend a tiny bit of those tax dollars we'd already paid.

    • (Score: 2, Disagree) by Azuma Hazuki on Tuesday May 19 2020, @12:49AM (11 children)

      by Azuma Hazuki (5086) on Tuesday May 19 2020, @12:49AM (#996105) Journal

      "Or else" what, pray tell? Because in a crony-capitalist milieu like the modern US, the "or else" is equally dire.

      --
      I am "that girl" your mother warned you about...
      • (Score: 2) by Reziac on Tuesday May 19 2020, @01:05AM (10 children)

        by Reziac (2489) on Tuesday May 19 2020, @01:05AM (#996111) Homepage

        Or else what? The best answer came from Lenin or Stalin or Mao, tho there have been plenty of also-rans (eg. Castro and Chavez).

        • (Score: 2) by Azuma Hazuki on Tuesday May 19 2020, @01:14AM (9 children)

          by Azuma Hazuki (5086) on Tuesday May 19 2020, @01:14AM (#996115) Journal

          Same shit happens here in the US, just slower: you die. I think I'd rather be shot than starve. You're dishonest as Hell, you know that?

          --
          I am "that girl" your mother warned you about...
          • (Score: 2) by Reziac on Tuesday May 19 2020, @02:49AM (8 children)

            by Reziac (2489) on Tuesday May 19 2020, @02:49AM (#996144) Homepage

            And you're pleasant company, as always.

            • (Score: 2) by Azuma Hazuki on Tuesday May 19 2020, @01:26PM (7 children)

              by Azuma Hazuki (5086) on Tuesday May 19 2020, @01:26PM (#996325) Journal

              Cry harder. I may be unpleasant to the deserving, but I'm also correct. If you don't like getting snarked at, don't say stupid shit.

              --
              I am "that girl" your mother warned you about...
              • (Score: 2, Insightful) by Reziac on Tuesday May 19 2020, @02:50PM (6 children)

                by Reziac (2489) on Tuesday May 19 2020, @02:50PM (#996362) Homepage

                No, you're unpleasant because you're wrong and you don't have a good argument, but you do have a fine stable of insults. We all use the skills we're able...

                ;)

                • (Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @12:24AM (5 children)

                  by Azuma Hazuki (5086) on Wednesday May 20 2020, @12:24AM (#996631) Journal

                  So this is what you descend to? No, I'm correct, and if I weren't you wouldn't be getting so upset about it. The nastiness is just the well-deserved icing on the cake. Fuck off, keep fucking off until you've circumnavigated the globe and fucked off right back to where you started, then fuck off one more time.

                  --
                  I am "that girl" your mother warned you about...
                  • (Score: 2, Funny) by Reziac on Wednesday May 20 2020, @12:39AM (4 children)

                    by Reziac (2489) on Wednesday May 20 2020, @12:39AM (#996636) Homepage

                    I'm not upset. I love you too. :D

                    • (Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @05:20AM (3 children)

                      by Azuma Hazuki (5086) on Wednesday May 20 2020, @05:20AM (#996757) Journal

                      Denial. Ain't just a big wet in Egypt.

                      --
                      I am "that girl" your mother warned you about...
                      • (Score: 2) by Reziac on Wednesday May 20 2020, @06:38AM (2 children)

                        by Reziac (2489) on Wednesday May 20 2020, @06:38AM (#996772) Homepage

                        You can get Depends for that...

                        • (Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @01:10PM (1 child)

                          by Azuma Hazuki (5086) on Wednesday May 20 2020, @01:10PM (#996861) Journal

                          If it weren't bothering you, *you wouldn't keep replying.* You fat middle-aged manchildren are all so goddamn *predictable.*

                          --
                          I am "that girl" your mother warned you about...
                          • (Score: 2) by Reziac on Wednesday May 20 2020, @02:45PM

                            by Reziac (2489) on Wednesday May 20 2020, @02:45PM (#996905) Homepage

                            No, I do it to keep YOU replying. Because you're so predictable. :D