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$15 drug gets COVID patients off oxygen support in under week – study:
Fourteen out of 15 severe COVID-19 patients who were treated in an investigator-initiated interventional open-label clinical study of the drug TriCor (fenofibrate)[*] didn't require oxygen support within a week of treatment and were released from the hospital, according to the results of a new Hebrew University of Jerusalem study.
Fenofibrate is an FDA-approved oral medication. The results were published on Researchsquare.com and are currently under peer review.
Specifically, the team that was led by HU's Prof. Yaakov Nahmias carried out the study at Israel's Barzilai Medical Center in coordination with the hospital's head of the Infectious Disease Unit, Prof. Shlomo Maayan, and with support from Abbott Laboratories.
[...] The 15 treated patients all had pneumonia and required oxygen support. They were also older with multiple comorbidities, ranging from diabetes and obesity to high blood pressure.
"The results were dramatic," Nahmias told The Jerusalem Post. "Progressive inflammation markers, which are the hallmark of deteriorative COVID-19, dropped within 48 hours of treatment. Moreover, 14 of the 15 severe patients didn't require oxygen support within a week of treatment." The 15th patient was off oxygen within 10 days.
When looking at the data on other similar severe patients, less than 30% of them on average are removed from oxygen support within a week. In other words, fenofibrate could dramatically shorten the treatment time for severe COVID patients.
"We know these kinds of patients deteriorate really fast, develop a cytokine storm in five to seven days and that it can take weeks to treat them and for them to get better," Nahmias said. "We gave these patients fenofibrate and the study shows inflammation dropped incredibly fast. They did not seem to develop a cytokine storm[**] at all."
Cytokine storms are aggressive inflammatory responses to illness.
[*] Fenofibrate entries on MedlinePlus and Wikipedia.
[**] Cytokine storm on Wikipedia.
Journal Reference:
Yaakov Nahmias, Avner Ehrlich, Konstantinos Ioannidis, et al. Metabolic Regulation of SARS-CoV-2 Infection, (DOI: 10.21203/rs.3.rs-770724/v1)
(Score: 1, Interesting) by Anonymous Coward on Saturday August 28 2021, @10:04PM (10 children)
Hello Martian, fancy to see you in Earth Internet!
Here on planet Earth, those of us who prefer to survive, tend to rely on word of mouth. People we know who recovered from this or that disease, recommend to us the doctors who treated them, and/or the medicines they used for the treatment. Those of us who lack medical knowledge of their own, also consult with relatives or friends who do have some.
Do things work totally differently on Mars?
(Score: 2) by Tork on Sunday August 29 2021, @12:04AM
I think he was asking about those people who apparently know Willy Wonka, Kermit the Frog, and Jim Halpert.
🏳️🌈 Proud Ally 🏳️🌈
(Score: 5, Insightful) by Opportunist on Sunday August 29 2021, @12:35AM (6 children)
Oh please, boomer, get with the times. You don't rely on relatives, today you turn to YouTubers and Twitter for medical advice.
(Score: 0) by Anonymous Coward on Sunday August 29 2021, @11:28AM (4 children)
Pfft YouTube and Twitter are sooo MySpace grandpa, now we use TikTok for our needs.
(Score: 0) by Anonymous Coward on Sunday August 29 2021, @04:55PM (3 children)
OMG tiktoc your soooo old what ru lik 19 or somethng?
(Score: 1) by pTamok on Sunday August 29 2021, @06:12PM (2 children)
So fake. Anyone investigating youth culture knows they don't use punctuation - its regarded as rude.
(Score: 2) by Opportunist on Monday August 30 2021, @09:19AM (1 child)
Then why do you use it boomer we have identified you because anyone chill these days uses run on sentences without period or comma which makes the whole crap really hard to read if you happen to know a thing or two about grammar but then who does because ... damn this message is too long doesn't fit in a tweet anymore
(Score: 1) by pTamok on Monday August 30 2021, @08:45PM
Samuel Beckett was obviously chill: How it is (1964) (Comment c'est) is entirely without punctuation for 147 pages.
It's cute watching young people believe they are doing something new.
(Score: 2) by DannyB on Monday August 30 2021, @02:01PM
And legal advice.
The lower I set my standards the more accomplishments I have.
(Score: 2) by driverless on Sunday August 29 2021, @05:18AM (1 child)
It's not their mouths that most of the people providing Covid advice in places like FB are talking out of...
(Score: 0) by Anonymous Coward on Sunday August 29 2021, @04:57PM
Word of ass?