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posted by martyb on Saturday August 28 2021, @08:44PM   Printer-friendly
from the good-fibrations dept.

$15 drug gets COVID patients off oxygen support in under week – study:

Fourteen out of 15 severe COVID-19 patients who were treated in an investigator-initiated interventional open-label clinical study of the drug TriCor (fenofibrate)[*] didn't require oxygen support within a week of treatment and were released from the hospital, according to the results of a new Hebrew University of Jerusalem study.

Fenofibrate is an FDA-approved oral medication. The results were published on Researchsquare.com and are currently under peer review.

Specifically, the team that was led by HU's Prof. Yaakov Nahmias carried out the study at Israel's Barzilai Medical Center in coordination with the hospital's head of the Infectious Disease Unit, Prof. Shlomo Maayan, and with support from Abbott Laboratories.

[...] The 15 treated patients all had pneumonia and required oxygen support. They were also older with multiple comorbidities, ranging from diabetes and obesity to high blood pressure.

"The results were dramatic," Nahmias told The Jerusalem Post. "Progressive inflammation markers, which are the hallmark of deteriorative COVID-19, dropped within 48 hours of treatment. Moreover, 14 of the 15 severe patients didn't require oxygen support within a week of treatment." The 15th patient was off oxygen within 10 days.

When looking at the data on other similar severe patients, less than 30% of them on average are removed from oxygen support within a week. In other words, fenofibrate could dramatically shorten the treatment time for severe COVID patients.

"We know these kinds of patients deteriorate really fast, develop a cytokine storm in five to seven days and that it can take weeks to treat them and for them to get better," Nahmias said. "We gave these patients fenofibrate and the study shows inflammation dropped incredibly fast. They did not seem to develop a cytokine storm[**] at all."

Cytokine storms are aggressive inflammatory responses to illness.

[*] Fenofibrate entries on MedlinePlus and Wikipedia.

[**] Cytokine storm on Wikipedia.

Journal Reference:
Yaakov Nahmias, Avner Ehrlich, Konstantinos Ioannidis, et al. Metabolic Regulation of SARS-CoV-2 Infection, (DOI: 10.21203/rs.3.rs-770724/v1)


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  • (Score: 5, Informative) by stretch611 on Sunday August 29 2021, @01:49AM (1 child)

    by stretch611 (6199) on Sunday August 29 2021, @01:49AM (#1171924)

    Wow... how many lies can you fit in a single sentence...

    People that are vaccinated are now getting COVID

    While true, this is only happening to about 1/6 or 1/8th the chance of unvaccinated individuals. And vaccinated people that get covid require hospitalization and/or die at a rate 1/25th of the unvaccinated. However, without the rapid spread among the unvaccinated, the virus would quickly burn out.

    there are people who can't take the vaccine for health reasons (pregnant, immunocompromised, etc)

    barely true, but extremely misguided.

    People who can get vaccinated that don't; increase the risks of everyone that can't get vaccinated. This is why we havev a history of vaccine mandates in this country... to protect those that can't be vaccinated. But, selfish assholes tend to not care about the effects of their own actions on others.

    As for pregnant women, from the CDC [cdc.gov]:

    • COVID-19 vaccination is recommended for all people 12 years and older, including people who are pregnant, breastfeeding, trying to get pregnant now, or might become pregnant in the future.
    • Evidence about the safety and effectiveness of COVID-19 vaccination during pregnancy has been growing. These data suggest that the benefits of receiving a COVID-19 vaccine outweigh any known or potential risks of vaccination during pregnancy.
    • There is currently no evidence that any vaccines, including COVID-19 vaccines, cause fertility problems in women or men.
    • Pregnant and recently pregnant people are more likely to get severely ill with COVID-19 compared with non-pregnant people.
    • Getting a COVID-19 vaccine can protect you from severe illness from COVID-19.

    So, being pregnant means that you have more reasons to get the vaccine, not the opposite which is what you claimed.

    As for the immunocompromised, They already have the option for a 3rd dose(in the US)... That hardly means that they should not get the vaccine. Of course there are many different ways for your immune system to be compromised, but these people should speak with their dr. first... (and not an internet quack.)

    because the vaccines have a much higher rate of serious side effects as compared to the traditional vaccines we have all had.

    A blatant lie. The covid vaccines have had the lowest rates of severe side effects than any vaccine in history.

    The vaccines are by themselves not enough to beat COVID.

    Well, you have one bit of truth here. We also need the unvaccinated idiots to pull their head out of their ass and get the vaccine before we can beat covid. (or wait for the darwin principle to fix that part.)

    --
    Now with 5 covid vaccine shots/boosters altering my DNA :P
    Starting Score:    1  point
    Moderation   +3  
       Flamebait=1, Troll=1, Informative=4, Touché=1, Total=7
    Extra 'Informative' Modifier   0  
    Karma-Bonus Modifier   +1  

    Total Score:   5  
  • (Score: -1, Troll) by Anonymous Coward on Sunday August 29 2021, @11:54AM

    by Anonymous Coward on Sunday August 29 2021, @11:54AM (#1172022)

    Parent said:

    because the vaccines have a much higher rate of serious side effects as compared to the traditional vaccines we have all had.
    A blatant lie. The covid vaccines have had the lowest rates of severe side effects than any vaccine in history.

    End quote.

    Stop shilling.

    Other vaccines did not result in myocarditis (heart inflammation) esp. in young people
    https://www.cdc.gov/vaccines/covid-19/clinical-considerations/myocarditis.html [cdc.gov]
    nor miscarriages in pregnant people nor in some cases death of the person receiving the vaccine. The side effects from these COVID vaccines are a thousand times worse than other vaccines.