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How far do you currently live from the town where you grew up?

  • less than 60 mi or 100 km
  • greater than that, but less than 300 mi or 500 km
  • greater than the above, but less than 600 mi or 1,000 km
  • greater than the above, but less than 3,000 mi or 5,000 km
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  • greater than the above, but less than 12,000 mi or 20,000 km
  • greater than 12,000 mi or 20,000 km (the truth is out there)
  • I never grew up, you insensitive clod!

[ Results | Polls ]
Comments:25 | Votes:103

posted by janrinok on Wednesday December 17, @11:01PM   Printer-friendly

https://www.wired.com/story/fulu-repair-bounties-nest-molekule/

Companies tend to be rather picky about who gets to poke around inside their products. Manufacturers sometimes even take steps that prevent consumers from repairing their device when it breaks, or modifying it with third-party products.

But those unsanctioned device modifications have become the raison d'être of a bounty program set up by a nonprofit called Fulu, or Freedom from Unethical Limitations on Users. The group tries to spotlight the ways companies can slip consumer-unfriendly features into their products, and it offers cash rewards in the thousands of dollars to anyone who can figure out how to disable unpopular features or bring discontinued products back to life.

"We want to be able to show lawmakers, look at all these things that could be out in the world," says right-to-repair advocate and Fulu cofounder Kevin O'Reilly. "Look at the ways we could be giving device owners control over their stuff."

Fulu has already awarded bounties for two fixes. One revives an older generation of Nest Thermostats no longer supported by Google. And just yesterday, Fulu announced a fix that circumvents restrictive digital-rights-management software on Molekule air purifiers.

Fulu is run by O'Reilly and fellow repair advocate and YouTuber Louis Rossmann, who announced the effort in a video on his channel in June.

The basic concept of Fulu is that it works like a bug bounty, the long running practice in software development where devs will offer prize money to people who find and fix a bug in the operating system. Fulu adopts that model, but the bounty it offers is usually meant to "fix" something the manufacturer considers an intended feature but turns out to be detrimental to the user experience. That can mean a device where the manufacturer has put in restrictions to prevent users from repairing their device, blocked the use of third-party replacement parts, or ended software support entirely.

"Innovation used to mean going from black-and-white to color," Rossmann says. "Now innovation means we have the ability to put DRM in an air filter."

Fulu offers up a bounty of $10,000 to the first person to prove they have a fix for the offending feature of a device. Donors can also pool money to help incentivize tinkerers to fix a particular product, which Fulu will match up to another $10,000. The pot grows as donations roll in.

Bounties are set on devices that Rossmann and O'Reilly have deemed deliberately hostile to the owners that have already paid for them, like some GE refrigerators that have DRM-locked water filters, and the Molekule air purifiers with DRM software that blocks customers from using third-party air filters. A bounty on the XBox Series X seeks a workaround to software encryption on the disk drive that prevents replacing the part without manufacturer approval. Thanks to donations, the prize for the Xbox fix has climbed to more than $30,000.

Sounds like a sweet payout for sure, but there is risk involved.

Fixing devices, even ones disabled and discontinued by the manufacturer, is often in direct violation of Section 1201 of the Digital Millennium Copyright Act, the 1998 US law that prevents bypassing passwords and encryption or selling equipment that could do so without manufacturer permission. Break into a device, futz with the software inside to keep it functional, or go around DRM restrictions, and you risk running afoul of the likes of Google's gargantuan legal arm. Fulu warns potential bounty hunters they must tackle this goal knowing full well they're doing so in open violation of Section 1201.

"The dampening effect on innovation and control and ownership are so massive," O'Reilly says. "We want to prove that these kinds of things can exist."

In October, Google ended software support for its first- and second-generation Nest thermostats. For lots of users, the devices still worked but couldn't be controlled anymore, because the software was no longer supported. Users lamented that their fancy thermostats had now become hunks of e-waste on their walls.

Fulu set up a bounty that called for a software fix to restore functionality to the affected Nest devices. Cody Kociemba, a longtime follower of Rossmann's YouTube channel and a Nest user himself, was eager to take the bounty on. (He has "beef with Google," he says on his website.) After a few days of tinkering with the Nest software, Kociemba had a solution. He made his fix publicly available on GitHub so users could download it and restore their thermostats. Kociemba also started No Longer Evil, a site devoted to his workaround of Nest thermostats and perhaps hacks of future Google products to come.

"My moral belief is that this should be accessible to people," Kociemba says.

Kociemba submitted his fix to Fulu, but discovered that another developer, calling themselves Team Dinosaur, had just submitted a fix slightly before Kociemba did. Still, Fulu paid out the full amount to both, roughly $14,000 apiece. Kociemba was surprised by that, as he thought he had lost the race or that he might have to split the prize money.

O'Reilly says that while they probably won't do double payouts again, both fixes worked, so it was important for Fulu's first payout to show support for the people willing to take the risk of sharing their fixes.

"Folks like Cody who are willing to put it out there, make the calculated risk that Google isn't going to sue them, and maybe save some thermostats from the junk heap and keep consumers from having to pay $700 or whatever after installation to get something new," O'Reilly says. "It's been cool to watch."

This week, Fulu announced it had paid out its second-ever bounty. It was for a Molekule Air Pro and Air Mini, air purifier systems that used an NFC chip in its filters to ensure the replacement filters were made by Molekule and not a third-party manufacturer. The goal was to disable the DRM and let the machine use any filter that fit.

Lorenzo Rizzotti, an Italian student and coder who had gone from playing Minecraft as a kid to reverse engineering and hacking, submitted proof that he had solved the problem, and was awarded the Fulu bounty.

"Once you buy a device, it's your hardware, it's no longer theirs," Rizzotti says. "You should be able to do whatever. I find it absurd that it's illegal."

But unlike Kociemba, he wasn't about to share the fix. Though he was able to fix the problem, he doesn't feel safe weathering the potential legal ramifications that he might face if he released the solution publicly.

"I proved that I can do it," he says. "And that was it."

Still, Fulu awarded him the bounty. O'Reilly says the goal of the project is less about getting actual fixes out in the world, and more about calling attention to the lengths companies are allowed to go to wrest control from their users under the auspices of Section 1201.

"We need to show how ridiculous it is that this 27-year-old law is preventing these solutions from seeing the light of day," O'Reilly says. "It's time for the laws to catch up with technology."


Original Submission

posted by janrinok on Wednesday December 17, @06:18PM   Printer-friendly

Norovirus Cases Surging in U.S.:

Cases of "winter vomiting disease," also known as norovirus, are rising ahead of schedule this year. Alexey Kuzma/Stocksy

  • "Winter vomiting disease" is on the rise across the United States, with norovirus cases surging since mid-October.
  • Wastewater surveillance and CDC testing indicate that norovirus is spreading earlier and faster than usual, particularly in Louisiana, Michigan, and Indiana.
  • The virus spreads easily through contaminated food, water, hands, and surfaces, and symptoms can appear within a short period.
  • Preventing infection from norovirus includes proper handwashing, disinfecting surfaces, avoiding shared food or utensils, and staying home and hydrated if you become sick.

Rising norovirus cases across the United States have many people wary of contracting the so-called "winter vomiting disease."

Data from WastewaterSCAN, a national monitoring program run by Stanford and Emory University, shows that norovirus levels have been rising since mid-October, with notable increases detected in Louisiana, Michigan, and Indiana.

Recent data from the Centers for Disease Control and Prevention (CDC) show 153 norovirus outbreaks reported from August to mid-November. The surge is considered ahead of schedule for the season, which typically peaks from November to April.

Despite this increase, norovirus outbreak trends are currently lower than last year, with 235 norovirus outbreaks reported during the same time period in 2024.

Norovirus is a highly contagious virus that spreads rapidly through contaminated food, water, hands, and surfaces.

With holiday travel and crowded indoor gatherings underway, conditions are ideal for the rapid transmission of this infectious disease, known to cause unpleasant gastrointestinal side effects.

Holiday travel and an increase in social gatherings can also contribute to the spread of norovirus.

"Close quarters and sharing food or being on crowded buses and trains, as well as touching so many things, create an environment that will allow Norovirus to spread before you even realise you've come into contact with someone who has it," Tesfu said.

Cold weather can also affect how well our immune system defends us. Lower vitamin D levels in winter and drier air can weaken natural immune barriers, making it easier for viruses like norovirus to spread.

Colder temps play a part, too. "The virus survives better in cool, dry air," Paria Sanaty Zadeh, PharmD, clinical pharmacist at Drugwatch, told Healthline.

Many people associate norovirus outbreaks with cruise ships, but the virus can also present in various other settings, including schools and nursing homes.

Norovirus infection may lead to telltale symptoms of vomiting and diarrhea, as the virus primarily affects the gut.

"Unlike the flu, norovirus targets the gut," Zadeh said. "It's a viral gastroenteritis, [or] what people call a 'stomach bug,' even though the virus affects the small intestine more than the stomach."

Norovirus typically has an abrupt onset, manifesting as vomiting and diarrhea, and is highly contagious.

"Getting it from contaminated hands or food is most common, either touching something contaminated and then touching your mouth, or eating something contaminated," Zadeh said.

"You can get it from touching a surface that wasn't cleaned well after someone was sick, then touching your mouth. And you only need a tiny amount of the virus to get infected. It moves and spreads easily."


Original Submission

posted by janrinok on Wednesday December 17, @01:34PM   Printer-friendly

https://arstechnica.com/tech-policy/2025/12/verizon-refused-to-unlock-mans-iphone-so-he-sued-the-carrier-and-won/

Verizon changed policy after he bought the phone, wouldn't unlock it despite FCC rule.

When Verizon refused to unlock an iPhone purchased by Kansas resident Patrick Roach, he had no intention of giving up without a fight. Roach sued the wireless carrier in small claims court and won.

Roach bought a discounted iPhone 16e from Verizon's Straight Talk brand on February 28, 2025, as a gift for his wife's birthday. He intended to pay for one month of service, cancel, and then switch the phone to the US Mobile service plan that the couple uses. Under federal rules that apply to Verizon and a Verizon unlocking policy that was in place when Roach bought the phone, this strategy should have worked.

"The best deals tend to be buying it from one of these MVNOs [Mobile Virtual Network Operators] and then activating it until it unlocks and then switching it to whatever you are planning to use it with. It usually saves you about half the value of the phone," Roach said in a phone interview.

Unlocking a phone allows it to be used with another carrier. Verizon, unlike other carriers, is required by the Federal Communications Commission to unlock phones shortly after they are activated on its network. Verizon gained significant benefits in exchange for agreeing to the unlocking requirement, first in 2008 when it purchased licenses to use 700 MHz spectrum that came with open access requirements and then in 2021 when it agreed to merger conditions to obtain approval for its purchase of TracFone.

Verizon is thus required to unlock handsets 60 days after they are activated on its network. This applies to Verizon's flagship brand and TracFone brands such as Straight Talk.

"That was the compromise. For their competitive advantage of acquiring the spectrum, they had to give up the ability to lock down phones for an extended period of time," Roach said.

But 60 days after Roach activated his phone, Verizon refused to unlock it. Verizon claimed it didn't have to because of a recent policy change in which Verizon decided to only unlock devices after "60 days of paid active service." Roach had only paid for one month of service on the phone.

The FCC-imposed restriction says Verizon must unlock phones 60 days after activation and doesn't say that Verizon may refuse to unlock a phone when a customer has not maintained paid service for 60 days. Moreover, Verizon implemented its "60 days of paid active service" policy for TracFone brands and Verizon prepaid phones on April 1, 2025, over a month after Roach bought the phone.

Company policy at the time Roach made the purchase was to unlock phones 60 days after activation, with no mention of needing 60 days of paid active service. In other words, Roach bought the phone under one policy, and Verizon refused to unlock it based on a different policy it implemented over a month later. Verizon's attempt to retroactively enforce its new policy on Roach was not looked upon favorably by a magistrate judge in District Court of Sedgwick County, Kansas.

"Under the KCPA [Kansas Consumer Protection Act], a consumer is not required to prove intent to defraud. The fact that after plaintiff purchased the phone, the defendant changed the requirements for unlocking it so that plaintiff could go to a different network essentially altered the nature of the device purchased... With the change in defendant's unlocking policy, the phone was essentially useless for the purpose plaintiff intended when he purchased it," Magistrate Judge Elizabeth Henry wrote in an October 2025 ruling.

There's still the question of why Verizon and its brands are demanding 60 days of paid active service before unlocking phones when the FCC-imposed conditions require it to unlock phones 60 days after activation. Roach filed a complaint to the FCC, alleging that Verizon violated the conditions. Verizon has meanwhile petitioned the FCC to eliminate the 60-day requirement altogether.

Before his small-claims court win, Roach turned down a Verizon settlement offer of $600 plus court fees because he didn't want to give up the right to speak about the case publicly. Roach said he filed an arbitration case against Verizon nearly a decade ago on a different matter related to gift cards that were supposed to be provided through a device recycling program. He said he can't reveal details about the settlement in that previous case because of a non-disclosure agreement.

After refusing Verizon's settlement offer in the new case, Roach gained a modest financial benefit from his court victory. The judge ordered Verizon to pay back the $410.40 he paid for the device, plus court costs and service fees.

When it appeared that the Straight Talk iPhone wouldn't be unlocked, Roach decided to buy an unlocked phone from Costco for $643.93. But he ended up returning that phone to Costco and paying Straight Talk for a second month of service to get the original phone unlocked, he said.

The now-unlocked phone—the one he bought from Straight Talk—is being used by his wife on their US Mobile plan. The court-ordered refund check that Verizon sent Roach included the phone cost and one month of service fees, he said.

Roach estimated he spent 20 or so hours on the suit, including arranging to have a summons served on Verizon and arguing his case in a court hearing. Roach didn't get much of a payout considering the amount of time he spent, "but it wasn't about that," he said.

Roach provided Ars with the emails in which Verizon offered the $600 settlement. A Verizon executive relations employee wrote to Roach, "My offer is not an admission of guilt but trying to extend the olive branch."

In his email declining the offer, Roach told Verizon, "I highly value the non-monetary outcomes I would achieve in court—transparency, accountability, and the absence of restrictions such as NDAs. Any settlement proposal that requires me to remain silent about the issue, while offering only modest monetary compensation, is less attractive to me than pursuing the matter through judgment. If Verizon Value is genuinely interested in settlement, the offer would need to reflect both the tangible costs I've incurred and the intangible but significant benefits the company receives by avoiding litigation and publicity."
"It was really starting to irk me"

The FCC has taken no action on Roach's complaint, and in fact, the commission could allow Verizon to scrap the 60-day requirement. As we reported in May, Verizon petitioned the FCC to let it lock phones to its network for longer periods of time. This would make it harder for customers to switch to other carriers, but Verizon claims longer locking periods are necessary to deter fraud.

The FCC hasn't ruled yet on Verizon's petition. Roach says Verizon seems to be acting as if it can change the rules without waiting for the FCC to do so formally. "It was really starting to irk me that they were basically just going ahead with it anyways while they had an open request," Roach said.

He doesn't expect the FCC to penalize Verizon, though. "It's just kind of slimy of them, so I feel like it deserves a spotlight," he said. "I'm not sure with the current state of the FCC that anything would happen, but the rule of law should be respected."

The Verizon petition to relax the unlocking requirements was opposed in a filing by Public Knowledge and other consumer advocacy groups. Public Knowledge Legal Director John Bergmayer, who wrote the filing, told Ars that Roach "has a pretty strong argument under the law as it stands."
Verizon must unlock phones automatically

The unlocking rules applying to Verizon used to be stricter, resulting in the company selling phones that were already unlocked. In 2019, Verizon requested a waiver to let it lock phones for 60 days.

The FCC granted the waiver in June 2019, allowing Verizon "to lock a customer's handset for 60 days from the date it becomes active on Verizon's network" and requiring it to unlock the handset once the period is over. This condition was expanded to TracFone and its brands such as Straight Talk in the 2021 merger, with the FCC approval stating that "For 700 MHz C Block TracFone devices that operate on the Verizon network and are capable of unlocking automatically (e.g., Apple devices), they will unlock automatically 60 days after activation."

The 2019 waiver grant said Verizon must automatically unlock phones after 60 days "regardless of whether: (1) the customer asks for the handset to be unlocked, or (2) the handset is fully paid off." The FCC order specifies that "the only exception to the rule will be that Verizon will not have to automatically unlock handsets that it determines within the 60-day period to have been purchased through fraud."

Bergmayer said the FCC order "granting the waiver just starts a countdown, with no 'paid service' requirement, or room for Verizon to just impose one. Many people may use prepaid phones that they don't keep in continuous service but just charge up as needed. Maybe people are fine with just having Wi-Fi on their phones for a while if they're at home anyway."

Given the restrictive nature of the FCC conditions, "I don't think that can be read to allow a paid service requirement," Bergmayer said. But as a practical matter, the FCC under Chairman Brendan Carr has been aggressively eliminating regulations that apply to telecom carriers under Carr's "Delete, Delete, Delete" initiative. To actually enforce Verizon's obligations under the current rules, "you have to convince the current FCC not to just change it," Bergmayer said.

The FCC and Verizon did not respond to requests for comment.
Retroactive policy change irked other buyers, too

Roach wasn't the only person whose plans to buy a discounted phone were thwarted by Verizon refusing to unlock the device after 60 days. Roach had learned of the discount offer from a Slick Deals thread. Eventually, users posting in that thread started reporting that they weren't able to get the phone unlocked.

"My status: I used 30 days with Straight Talk. Waited another 35 days but it did not unlock," one person wrote.

Some people in the thread said they canceled after 30 days, like Roach did, but eventually bought a second month of service in order to get the unlock. Although Verizon and its brands are required to unlock phones automatically, some commenters said they had to contact Straight Talk support to get an unlock. "Needless to say this has been an arduous journey. Good luck to others and hope you manage to successfully unlock your devices as well," one user wrote.

There's also a Reddit thread started by someone who said they bought a Samsung phone in February and complained that Straight Talk refused to honor the unlocking policy that was in place at the time.

"I called to ask for the phone to be unlocked on April 16 but was told it can't be unlocked since it did not have 60 days of paid service," the Reddit user wrote. "When I said that was not the policy on phones activated prior to April 1, the rep told me 'we have the right to change our policy.' I agreed, they do [have] the right to change their policy GOING FORWARD but can't change the rules going backwards. He disagreed."
FCC complaint didn't go anywhere

Roach's FCC complaint received a response from Verizon, but nothing substantial from the FCC itself. "There's not really any sort of moderation or mediation from the FCC, it's just kind of a dialogue between you and the other party. And I'm not really sure if any human eyes from the government even look at it. It's probably just a data point," Roach said.

Roach had previously called Straight Talk customer service about the changed terms. "There were a couple phone calls involved, and they were just very unrelenting that the only way that thing was getting unlocked is with the extra month of paid service," he said.

In its formal response to the FCC, Verizon's TracFone division asserted that it could apply the April 1, 2025, policy change to the phone that Roach bought over a month earlier. The carrier's letter to the FCC said:

We understand Mr. Roach's desire to use his device on another carrier's network, and we want to provide clarity based on our Unlocking Policy, which became effective on April 1, 2025. As outlined in our policy, for cellphones capable of remote unlocking (this includes most iPhones and some Android cellphones) that were activated with Straight Talk service prior to November 23, 2021, on any carrier network, the device becomes eligible for remote unlocking upon the customer's request after 60 days of active paid service.

Our redemption records indicate that Mr. Roach's account does not have the required minimum 60 days of active paid service based on the payment records. Therefore, the device does not currently meet the eligibility criteria for unlocking as outlined in our policy. Once the account reflects the required 60 days of active paid service, and the device meets the other conditions, he can resubmit the unlocking request.

Verizon's letter did not explain how its new policy complies with the FCC conditions or why the new policy should apply to phones purchased before the policy was in place.

Roach's complaint said the FCC should force Straight Talk to "honor the FCC-mandated 60-day post-activation unlock condition for all affected phones, without imposing the additional 'paid service' requirement." His complaint further urged the FCC to "investigate this practice as a violation of FCC rules and the merger conditions" and "take enforcement action to protect consumers' rights."

"Straight Talk's new policy conflicts with the FCC's binding conditions," Roach told the agency. "The Commission's order clearly requires unlocking after 60 days from activation, with no additional obligation to maintain service. By conditioning unlocks on two months of service, Straight Talk is effectively adding a term that Verizon did not promise and the FCC did not approve."

In his small claims court filing, Roach alleged that Verizon and Straight violated the FCC conditions and that the retroactive application of the "60 days of paid service" term, without disclosure at the point of sale, is an unfair and deceptive practice prohibited by the Kansas Consumer Protection Act.

The magistrate judge's ruling in Roach's favor said, "It does appear that defendant's change unlocking policy is contrary to the applicable FCC regulations." She noted that federal communications law does not prevent users from suing carriers individually and that the Kansas Consumer Protection Act "contains provisions prohibiting deceptive acts by a supplier which would be applicable in this case."

Roach asked for $10,000, mainly because that was the limit on damages in the venue, but the judge decided to award him damages in the amount of his actual losses. "He lost the benefit of the bargain he made with defendant such that his damages were loss of the $410.40," the ruling said.

Straight Talk's terms of service require disputes to be resolved either in arbitration or small claims court. Verizon pays the arbitration fees if users go that route. Arbitration is "a little more murky" in terms of how the parties' interests are aligned, Roach said.

"When the arbitrators are being paid by Verizon, are they really a neutral party?" he said. Roach also said he "thought it was honestly just a good opportunity for an easy win and an opportunity to learn about the small claims court system a bit. So at that point I was like, if I don't make any money from this, whatever, but at least I'll learn a little bit about the process."

Roach said he did not consult with a lawyer on his small claims case, instead opting to do it all himself. "The first time I showed up to court for the original date, they asked for proof of the returned mail summons, and I did not have that," he said.

The court hearing was rescheduled. When it was eventually held, the carrier sent a representative to argue against Roach.

"Their argument was pretty weak, I guess," Roach said. "It was basically like, 'Well, he didn't pay the two months of service, so we didn't unlock his phone. We offered him a settlement but he rejected it.'... My argument was, yeah, the terms had changed in kind of a consumer-unfriendly way. But beyond that, it was the fact that the terms had changed from something that was legal to something that was not legal with the federal regs. So regardless of the fact that the terms had changed, the current terms were illegal, which I thought was my strongest argument. And then I also put in that it was probably a violation of Kansas consumer protection law, which I'm glad I did."

Roach said that toward the end of the hearing, the judge indicated that she couldn't make a judgment based on FCC regulations and would need to rule on what the Kansas court has jurisdiction over. She issued the ruling that Verizon violated the state's consumer protection law about five or six weeks later, he said.

Given that the FCC hasn't acted on Verizon's petition to change the unlocking rules, the federal regulations "haven't changed at all in regards to Verizon's obligation to unlock devices," Roach said. He believes it would be relatively easy for consumers who were similarly harmed to beat Verizon in court or even to pursue a class action.

"I would think this would be a slam dunk for any further cases," Roach said. "I don't think I have any grounds anymore since my damages have been resolved, but it seems like it'd be a very easy class action for somebody."

= Links are in the article.


Original Submission

posted by janrinok on Wednesday December 17, @08:48AM   Printer-friendly
from the clap-hands dept.

https://scitechdaily.com/a-simple-pill-could-replace-injections-for-treating-gonorrhea/

Researchers are testing a new single-dose pill that could make treating gonorrhea easier as antibiotic resistance rises.

A new antibiotic pill called zoliflodacin could become an important option for treating gonorrhea as the infection grows harder to cure with existing drugs. In a phase 3 clinical trial published in The Lancet, researchers reported that a single oral dose of zoliflodacin worked about as well as the long-used standard approach that relies on two antibiotics: a ceftriaxone injection followed by an oral dose of azithromycin.

Gonorrhea is a common sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae. The World Health Organization (WHO) estimated that in 2020 there were 82·4 million new cases worldwide among people aged 15–49 years. Treatment matters because untreated gonorrhea can lead to serious complications, and infection can also increase the risk of acquiring or transmitting HIV. The challenge is that N gonorrhea has gradually developed resistance to every class of antibiotics previously used against it, leaving fewer reliable options.

Surveillance data cited by the researchers describe growing concern in several regions, including reports of rising azithromycin resistance and increasing multidrug resistance, with especially worrying signals involving ceftriaxone susceptibility in places such as Cambodia and Viet Nam.

Zoliflodacin is a first-in-class spiropyrimidinetrione antibiotic that kills the bacteria by disrupting DNA replication, mainly by targeting the GyrB subunit of DNA gyrase. This is distinct from fluoroquinolones, which primarily act on other bacterial targets. Earlier work showed zoliflodacin can remain active in laboratory testing against strains resistant to ciprofloxacin, ceftriaxone, and azithromycin, and modelling supported a single 3 g oral regimen.

The phase 3 trial enrolled more than 900 people across 17 outpatient clinics in five countries (USA, South Africa, Thailand, Belgium, and the Netherlands). Participants received either the new pill or the standard treatment. Results showed that zoliflodacin cured over 90% of infections at genital sites.

Results showed that zoliflodacin cured over 90% of infections at genital sites. The medication was well tolerated, with side effects similar to those seen with current treatments, and no serious safety issues were reported. The investigators also reported no evidence that resistance to zoliflodacin emerged during the trial based on the laboratory findings they tracked from baseline to test of cure.

Zoliflodacin is awaiting review by the U.S. Food and Drug Administration (FDA). If it is approved, the authors argue that a single-dose oral option could strengthen efforts to control drug-resistant gonorrhea, make treatment easier to deliver in more settings (including community-led care), and help protect reproductive health for millions of people by improving access to effective therapy worldwide.

Reference: “Zoliflodacin versus ceftriaxone plus azithromycin for treatment of uncomplicated urogenital gonorrhoea: an international, randomised, controlled, open-label, phase 3, non-inferiority clinical trial” by Alison Luckey, Manica Balasegaram, Lindley A Barbee, et al. 11 December 2025, The Lancet.

DOI: 10.1016/S0140-6736(25)01953-1


Original Submission

posted by janrinok on Wednesday December 17, @04:03AM   Printer-friendly

Cheaper and faster than building a nuclear reactor

By either the end of Friday or Monday, Australia will have surpassed 100,000 small battery systems installed and registered since 1 July when batteries became eligible for the STC rebate under the Small Scale Renewable Energy Scheme.

The capacity of household batteries registered in the 17 weeks since July 1 is just under 2,000 megawatt-hours (MWh). To put this into perspective it is enough capacity to cover the average daily electricity consumption of almost 400,000 households and is 15 times the size of the original South Australian Hornsdale Big Battery.

[...] In the first three weeks we see rapid growth. This doesn't reflect actual install rates, because systems were being installed at high rates even before 1 July. Instead, this represents an initial learning, scale-up phase related to the administration processes involved in claiming STCs from the regulator.

Then from the fourth week we look to have hit a ceiling flat-line of about a 1000 systems per working day. This lasted for the next seven weeks.

Our discussions with industry participants indicated this had nothing to do with underlying demand, which was running hot. Instead, it was a function of constraints in obtaining battery equipment and electricians with the required accreditation in battery installation.

But then from the 12th week we look to have been able to break free of that initial constraint to enter a new higher-level constraint of around 1500 systems per working day.

[...] The other fascinating thing for nerds like me, is that the size of batteries being installed is much larger than the historical norm, and far larger than most households will need to meet their own consumption requirements.

The chart below shows in the green bars the average size of system registered each day, while the blue line shows the seven-day moving average of system size. The seven-day moving average has us at close to 25 kilowatt-hours (kWh) average system size.

By comparison the average Australian household tends to consume around 12 kilowatt-hours of electricity per day*. Although if a household was to own two electric vehicles and dump gas then their consumption would likely double, making that battery not so oversized.

Some see such oversized battery systems as a bad thing, but households choosing to install larger battery systems achieves major labour productivity gains and provides the power system with extra storage capacity at much lower economic cost than if they were to stick to a small system.

Also, the fact that households are installing batteries larger than their own consumption needs isn't actually unusual – we've done exactly the same thing with solar. Over last financial year the average household solar system reached 9.1 kW. This produces 80% more electricity than the typical home could consume, with the remainder exported to the grid.

Another way to think about battery size is that it is sized not just to meet a household's own needs but also to soak up all the household's solar generation so it can be re-directed into a higher value period of the electricity market.

With this lens on, a 25 kWh battery makes much more sense. That's because the average new 9 kW solar system will usually produce an average of about 28 kWh of power excess to a household's daytime load. This quite closely matches the storage capacity of the typical battery now being installed.

But for this to all work we need to make sure that two things happen:

  • Batteries are coupled with control software that will export excess power to the grid during the evening peak demand period (4pm to 9pm);
  • We see far more electricity retailers offering time varying feed-in tariffs that provide a premium for power exported during the evening peak period that reflects the far higher wholesale power prices during this time.

Original Submission

posted by jelizondo on Tuesday December 16, @11:18PM   Printer-friendly

https://scitechdaily.com/breaking-a-50-year-law-new-evidence-challenges-fundamental-black-hole-physics/

New observations suggest that the relationship between light emitted by quasars has changed over cosmic time, hinting that the structure around supermassive black holes may not be as universal as once thought.

Astronomers from around the world have uncovered strong evidence suggesting that the material surrounding supermassive black holes has not remained the same throughout the history of the universe.

If confirmed, the findings from a study led by the National Observatory of Athens and published in Monthly Notices of the Royal Astronomical Society could overturn a key assumption that has shaped black hole research for nearly fifty years.

Quasars, which were first recognized in the 1960s, rank among the most luminous objects ever observed. Their extraordinary brightness comes from supermassive black holes that draw in nearby matter through intense gravitational forces. As this material falls inward, it forms a rapidly rotating disc that ultimately feeds the black hole.

The disc heats up to extreme temperatures as particles collide and rub against one another while orbiting the black hole. This process releases an astonishing amount of energy, producing between 100 and 1,000 times more light than an entire galaxy made up of roughly 100 billion stars. The resulting ultraviolet radiation is so powerful that telescopes can detect quasars across immense distances, even near the farthest reaches of the observable universe.

The ultraviolet light of the disc is also believed to be the fuel for the much more energetic X-ray light produced by quasars: the ultraviolet light rays as they travel through space intercept clouds of highly energetic particles very close to the black hole, a structure also known as the "corona".

As they bounce off these energetic particles, the ultraviolet rays are boosted in energy and generate intense X-ray light that our detectors can also spot.

Because of their shared history, the X-ray and ultraviolet emissions of quasars are tightly connected – brighter ultraviolet light typically means stronger X-ray intensity. This correlation, discovered nearly 50 years ago, provides fundamental insights into the geometry and physical conditions of the material close to supermassive black holes and has been the focus of intense research for decades.

The latest research adds a new twist to previous studies by challenging the universality of the correlation – a fundamental assumption that implies that the structure of matter around black holes is similar throughout the universe.

It shows that when the universe was younger – about half its present age – the correlation between the X-ray and ultraviolet light of quasars was significantly different from that observed in the nearby universe. The discovery suggests that the physical processes linking the accretion disc and the corona around supermassive black holes may have changed over the last 6.5 billion years of cosmic history.

"Confirming a non-universal X-ray-to-ultraviolet relation with cosmic time is quite surprising and challenges our understanding of how supermassive black holes grow and radiate," said Dr. Antonis Georgakakis, one of the study's authors.

"We tested the result using different approaches, but it appears to be persistent."

The study combines new X-ray observations from eROSITA X-ray telescope and archival data from the XMM-Newton X-ray observatory of the European Space Agency to explore the relation between X-ray and ultraviolet light intensity of an unprecedentedly large sample of quasars. The new eROSITA's wide and uniform X-ray coverage proved decisive, enabling the team to study quasar populations on a scale never before possible.

The universality of the UV-to-X-ray relation underpins certain methods that use quasars as "standard candles" to measure the geometry of the universe and ultimately probe the nature of dark matter and dark energy. This new result highlights the necessity for caution, demonstrating that the assumption of unchanging black hole structure across cosmic time must be rigorously re-examined.

"The key advance here is methodological," said postdoctoral researcher Maria Chira, of the National Observatory of Athens, who is the paper's lead author.

"The eROSITA survey is vast but relatively shallow – many quasars are detected with only a few X-ray photons. By combining these data in a robust Bayesian statistical framework, we could uncover subtle trends that would otherwise remain hidden."

The full set of eROSITA all-sky scans will soon allow astronomers to probe even fainter and more distant quasars. Future analyses using these data – together with next-generation X-ray and multiwavelength surveys – will help reveal whether the observed evolution reflects a genuine physical change or simply selection effects.

Such studies will bring new insight into how supermassive black holes power the most luminous objects in the universe, and how their behavior has evolved over cosmic time.

Reference: “Revisiting the X-ray-to-UV relation of quasars in the era of all-sky surveys” by Maria Chira, Antonis Georgakakis, Angel Ruiz, Shi-Jiang Chen, Johannes Buchner, Amy L Rankine, Elias Kammoun, Catarina Aydar, Mara Salvato, Andrea Merloni and Mirko Krumpe, 11 December 2025, Monthly Notices of the Royal Astronomical Society.

DOI: 10.1093/mnras/staf1905


Original Submission

posted by jelizondo on Tuesday December 16, @06:27PM   Printer-friendly
from the addressing-your-otolaryngological-needs dept.

A program of smell screening, awareness campaigns and health policies could improve the mental and physical health of millions:

Smell dysfunction is present in more than 130 neurological, somatic and hereditary disorders, with some evidence suggesting a causal role.

But a new paper published today reveals how smell is overlooked as a "Cinderella sense" in public health.

And researchers are calling for a worldwide campaign to put smell health on the map - with screening, education and awareness at its core.

Lead researcher Prof Carl Philpott, from UEA's Norwich Medical School, said: "A good sense of smell is vital for physical and mental health, and social wellbeing.

"However, smell remains a Cinderella sense which has lagged behind sight and hearing in terms of its perceived importance.

"Smell health underpins good nutrition, cognitive function, and psychological resilience. But national public health agendas around the world rarely consider smell health.

"Even before the emergence of Covid-19, smell disorders were very common but under-rated, under-researched, and under-treated sensory loss.

"Smell issues occur in at least 139 different neurological, physical, and inherited conditions. Research suggests smell loss may play a causal role because it often appears early and can predict future health issues.

"Increasing evidence has shown that smell loss is an independent risk factor for neurodegenerative disorders, increased frailty and reduced longevity."

To address this gap, the team are calling for education, awareness campaigns, and targeted public health policies that make smell health a priority.

Prof Philpott said: "The sense of smell should be promoted as an essential pillar of health, as it enables good nutrition and cognitive and psychological well-being.

"We recommend developing smell health educational programmes and awareness campaigns, introducing smell screening and developing and implementing smell health policies across all sectors of society.

"Inclusive efforts are particularly needed to ensure equity and diversity, particularly given the current demographic as those seeking help are typically not from a diverse cross-section of the community," he added.

It is interesting we regularly test vision and hearing, but don't regularly test the other senses.

Journal Reference: Carl Martin Philpott, Thomas Hummel, Valentina Parma, et al., The Need to Promote Olfactory Health in Public Health Agendas Across the Globe [OPEN], Clinical Otolaryngology, First published: 24 November 2025 DOI: https://doi.org/10.1111/coa.70056


Original Submission

posted by jelizondo on Tuesday December 16, @01:45PM   Printer-friendly

https://9to5linux.com/kali-linux-2025-4-ethical-hacking-distro-released-with-kde-plasma-6-5-gnome-49

This release also updates the Xfce desktop environment with support for color themes and introduces support for virtual machine guest tools.

Offensive Security announced today the release and general availability of Kali Linux 2025.4 as the fourth and last update to this Debian-based distribution for ethical hacking and penetration testing in 2025.

Coming almost three months after Kali Linux 2025.3, the Kali Linux 2025.4 release updates the GNOME and KDE Plasma desktop offerings to the latest GNOME 49 and KDE Plasma 6.5 releases, in addition to Xfce 4.20, which remains the default desktop environment.

The GNOME offering defaults to Wayland only, has an updated app grid that now organizes the Kali tools into folders, adopts Showtime as the default video player instead of Totem, and adds the Ctrl+Alt+T or Super+T keyboard shortcuts for quickly opening a terminal window.

The default Xfce desktop environment received some attention too in Kali Linux 2025.4 with the addition of support for color themes for icons, GTK 3/4 windows, Qt 5/6 windows, and Xfce's window manager decorations in the Appearance application.

For those running Kali Linux in a virtual machine, this release introduces support for virtual machine guest tools, such as clipboard sharing and window scaling in VirtualBox, QEMU, and VMware. The devs said that "all of the VM guest additions that you expected in X11 before are now working in Wayland without trouble."

Three new tools have been added in Kali Linux 2025.4, namely bpf-linker, a simple BPF static linker, evil-winrm-py, a Python-based tool for executing commands on remote Windows machines using WinRM, and hexstrike-ai, an MCP server that lets AI agents autonomously run tools.

Other than that, this release introduces a Halloween Mode for the Xfce desktop and updates Kali NetHunter with support for Android 16 devices like the Samsung Galaxy S10, S10e, S10 Plus, and S10 5G running LineageOS 23, improved terminal, updated Wifipumpkin3 tab with preview support, and an updated kernel install tab.

You can download Kali Linux 2025.4 from the official website in various flavors for 64-bit, ARM, VM, Cloud, WSL, or mobile platforms. Existing Kali Linux users need only to update their installations by running the sudo apt update && sudo apt full-upgrade commands in a terminal emulator.


Original Submission

posted by jelizondo on Tuesday December 16, @09:02AM   Printer-friendly

Scientists Discover Early Alzheimer's Warning Sign Hiding in Routine Brain Scans

Researchers from Nanyang Technological University, Singapore (NTU Singapore) have found that the brain's natural "drains", which help remove toxic waste from the organ, are more likely to become blocked in people who show early signs of Alzheimer's disease.

Their findings indicate that these blockages, known as "enlarged perivascular spaces", could serve as an important early signal of Alzheimer's, one of the most common forms of dementia.

"Since these brain anomalies can be visually identified on routine magnetic resonance imaging (MRI) scans performed to evaluate cognitive decline, identifying them could complement existing methods to detect Alzheimer's earlier, without having to do and pay for additional tests," said Associate Professor Nagaendran Kandiah from NTU's Lee Kong Chian School of Medicine (LKCMedicine) who led the study.

Justin Ong, a fifth-year LKCMedicine student and first author of the study, noted that spotting Alzheimer's at an early stage allows doctors to intervene sooner and potentially slow the progression of symptoms such as memory loss, reduced processing speed, and mood changes. The study was carried out as part of LKCMedicine's Scholarly Project module in the Bachelor of Medicine and Bachelor of Surgery program.

This research stands out because it is one of the few global studies that focus on Asian populations, rather than primarily Caucasian participants. The team examined nearly 1,000 people in Singapore from various ethnic groups, comparing individuals with no cognitive concerns to those showing mild difficulties in thinking.

These Asian-focused studies are important because past work suggests that dementia-related conditions vary across ethnicities.

"For example, among Caucasians with dementia, past studies show that the prevalence of a major risk gene, apolipoprotein E4, linked to Alzheimer's is around 50 to 60 per cent. But among Singapore dementia patients, it is less than 20 per cent," said Assoc Prof Kandiah, who is also Director of the Dementia Research Centre (Singapore)in LKCMedicine. So, findings in studies on Caucasian patients might not be observed in Asians and vice versa.

The brain's blood vessels are surrounded by small channels called perivascular spaces. These serve as pathways for clearing harmful waste such as beta amyloid and tau proteins, both of which appear in unusually high amounts in people with Alzheimer's.

When this drainage system becomes inefficient, the spaces expand and form enlarged perivascular spaces that are detectable on MRI scans. However, previous studies had not fully clarified whether this phenomenon was directly associated with dementia or specifically with Alzheimer's disease.

To investigate further, the NTU team compared the clogged brain drains with a wider range of Alzheimer's indicators than in earlier studies. They also evaluated how these blockages related to hallmark signs of the disease, including beta amyloid buildup and damage to the brain's white matter, a network of nerve fibers that links different brain regions.

The researchers studied close to 1,000 participants in Singapore, including nearly 350 who do not have any cognitive problems, meaning their mental abilities, such as their ability to think, remember, reason, make decisions, and focus, are normal.

The rest of the participants had features suggesting early stages of cognitive disease, including mild cognitive impairment, which is a stage that precedes overt dementia. According to past research, those with mild cognitive impairment have a higher risk of developing dementia, like Alzheimer's disease and vascular dementia, which is a type of dementia caused by reduced blood flow to the brain.

For the latest study, the researchers analyzed the MRI scans of the participants and found that those with mild cognitive impairment tend to have clogged drains in their brains, or enlarged perivascular spaces, compared to the other participants.

The scientists also took seven measurements based on specific biochemicals in the participants' blood, including beta amyloid and tau proteins. Their presence is a warning sign that a person has Alzheimer's.

The presence of clogged drains in the brain was linked to four of the seven measurements. So, people with enlarged perivascular spaces are likely to have more amyloid plaques, tau tangles, and brain cell damage in their brains than normal, and are thus at higher risk of developing Alzheimer's.

The researchers also studied if damage to the brain's white matter, a well-known indicator of Alzheimer's, was linked to the biochemicals tied to the disease, and they did find such links with six of the seven biochemical measurements, but with a twist.

They further compared the white matter damage against enlarged perivascular spaces, and discovered that in participants with mild cognitive impairment, the link with biochemicals tied to Alzheimer's was stronger for enlarged perivascular spaces than for white matter damage. This suggests that choked brain drains are early indicators of Alzheimer's disease.

Knowing all this allows clinicians to better figure out what kind of treatment they should use to slow and prevent Alzheimer's early, possibly before permanent brain damage has happened.

Clinical significance and expert interpretation

"The findings carry substantial clinical implications," said Assoc Prof Kandiah. "Although white matter damage is more widely used in clinical practice to evaluate for dementia, as it is easily recognised on MRI scans, our results suggest that enlarged perivascular spaces may hold unique value in detecting early signs of Alzheimer's disease."

Dr Rachel Cheong Chin Yee, a Senior Consultant and Deputy Head at Khoo Teck Puat Hospital's Department of Geriatric Medicine, said that the study highlights how changes in the brain's small blood vessels – in this case, enlarged perivascular spaces that surround the blood vessels and help clear waste from the brain – may contribute to Alzheimer's disease.

"These findings are significant because they suggest that brain scans showing enlarged perivascular spaces could potentially help identify people at higher risk of Alzheimer's disease, even before symptoms appear," said Dr Cheong, who was not involved in the study.

Dr Chong Yao Feng, a Consultant at the National University Hospital's Division of Neurology and who was also not involved in the NTU study, said that cerebrovascular diseases – conditions that cause problems in the blood vessels of the brain – and Alzheimer's disease are traditionally believed to be caused by different processes.

"The study's findings are intriguing as they demonstrate that both diseases do interact in a synergistic manner," said Dr Chong, who is also a Clinical Assistant Professor at the National University of Singapore's Yong Loo Lin School of Medicine.

So, if a doctor orders an MRI brain scan to evaluate a patient's cognitive symptoms and notices that the scan shows markers of cerebrovascular diseases, such as the enlarged perivascular spaces investigated in the NTU study, the clinician should not assume the patient's cognitive impairment is due only to blood vessel problems. This is because the markers' presence might increase the risk of the patient also having Alzheimer's disease.

"Doctors will then have to use their clinical judgment of the patient's scan and symptoms, as well as discuss with the patient, to determine if more checks are needed to confirm whether a patient has Alzheimer's disease or not," said Dr Chong.

The NTU research team plans to follow up on the study participants to check how many go on to develop Alzheimer's dementia and to confirm that enlarged perivascular spaces can predict that people with these choked drains are more likely to progress to dementia.

Also, with more studies establishing the link between the clogged drains and Alzheimer's in other populations, detecting enlarged perivascular spaces in MRI scans could one day be added to the existing tools available to clinicians to determine much earlier whether a patient will develop Alzheimer's.

Reference: “Association of Enlarged Perivascular Spaces With Early Serum and Neuroimaging Biomarkers of Alzheimer Disease Pathology” by Justin Jit Hong Ong, Yi Jin Leow, Bocheng Qiu, Pricilia Tanoto, Fatin Zahra Zailan, Gurveen Kaur Sandhu and Nagaendran Kandiah, 22 August 2025, Neurology.

DOI: 10.1212/WNL.0000000000213836


Original Submission

posted by mrpg on Tuesday December 16, @04:15AM   Printer-friendly

https://www.scientificamerican.com/article/u-s-approves-first-device-to-treat-depression-with-brain-stimulation-at-home/

In a first, this week the U.S. Food and Drug Administration approved a brain stimulation device designed to treat depression at home. The approval of the first such device for home depression treatment expands therapeutic options for depression beyond drugs.

Made by Flow Neuroscience, the device is worn as a headset that delivers electric current to a part of the brain called the dorsolateral prefrontal cortex, which is known to be implicated in mood disorders and depression. The technique, known as transcranial direct current stimulation (tDCS), has its skeptics. A 2023 trial published in the Lancet found tDCS to be no better than a placebo for treating depression, while other investigations, including trials funded by Flow Neuroscience, have shown some benefit.

[...] Key to the FDA approval was a 2024 phase 2 trial involving 174 people. Participants who wore the headset for 30-minute sessions over 10 weeks reported experiencing significant relief from their depression symptoms compared with controls who did not use the headset. In a document summarizing the data backing its decision, the FDA said that the headset's benefit, "while modest, is sufficient to outweigh its probable risk." The agency pointed to headaches and skin irritation as among the possible risks of the device.

[...] "Flow's FDA approval is a watershed moment for the treatment of depression: the first step in moving from pharmaceutical treatments to tech-based therapies with minimal side effects," said Erin Lee, Flow Neuroscience's CEO, in a recent statement.

The FDA's approval will make the headset available by prescription to treat moderate to severe major depressive disorder in adults. The company is negotiating with health insurance providers over possible coverage for the device, which is likely to cost between $500 and $800, according to Reuters.

= Links in article:

https://www.scientificamerican.com/article/does-brain-stimulation-boost-memory-and-focus-huge-study-tries-to-settle-debate/
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00640-2/fulltext
https://www.nature.com/articles/s41591-024-03305-y
https://www.accessdata.fda.gov/cdrh_docs/pdf23/P230024B.pdf
https://www.flowneuroscience.com/fda-approved-lp-2/
https://www.reuters.com/business/healthcare-pharmaceuticals/us-fda-approves-first-at-home-device-depression-2025-12-11/


Original Submission

posted by mrpg on Monday December 15, @11:39PM   Printer-friendly

Specific musical features have the power to make people bounce or sway:

Some music is for grooving: It evokes spontaneous dancing, like head bopping, jumping, or arm swinging. Other music is for swaying, or for crying, or for slow dancing. Music makes people move, but whether musicians intentionally induce specific movements with their compositions, such as vertical bouncing or horizontal swaying, or what musical features would contribute to these distinctions, is more complex.

Shimpei Ikegami, an associate professor at Showa Women's University, sought to understand how musicians express intended bodily movement directions using specific acoustic features.

"It's almost magical how something we hear with our ears can influence our entire body. In Japan, we even have terms to describe distinct rhythmic feelings to music," Ikegami said.

[...] Ikegami's findings suggest that the way musicians express certain qualities of danceability is specific and quantifiable. He aims to further explore commonalities and differences between musical profiles that induce vertical versus horizontal bodily movement.

"In the immediate future, I am investigating the psychological impressions — how the music is perceived by listeners. I am also deeply interested in cultural differences in these phenomena," said Ikegami. "I believe that advancing my understanding of how music influences our body movements could be beneficial in fields such as health care, rehabilitation, and education."


Original Submission

posted by mrpg on Monday December 15, @07:01PM   Printer-friendly
from the do-you-have-any-idea-how-fast-you-were-going? dept.

Researchers exploit gravitational lensing to see how fast the universe is really expanding:

There is an important and unresolved tension in cosmology regarding the rate at which the universe is expanding, and resolving this could reveal new physics. Astronomers constantly seek new ways to measure this expansion in case there may be unknown errors in data from conventional markers such as supernovae. Recently, researchers including those from the University of Tokyo measured the expansion of the universe using novel techniques and new data from the latest telescopes. Their method exploits the way light from extremely distant objects takes multiple pathways to get to us. Differences in these pathways help improve models on what happens at the largest cosmological scales, including expansion.

The universe is big, and it's getting bigger. How big is it? We don't really know. But we do know how fast it's expanding. It's not a simple matter, however, as the expansion appears faster the farther away we observe. For every 3.3 million light years (or one megaparsec) of distance from us, we see things at that distance running away from us at increasing multiples of about 73 kilometers per second. In other words, the rate of expansion of the universe is 73 kilometers per second per megaparsec (km/s/Mpc), also known as the Hubble constant.

There are different ways to ascertain the Hubble constant, but until now, all have relied on so-called distance ladders. These are things like supernovae or special stars called Cepheid variable stars, both of which are thought to be well understood enough such that their presence even in other galaxies ought to afford us accurate measurements about them, including their distances. By observing enough of these over the decades, the Hubble constant has been increasingly constrained. But there has always been a degree of doubt about this method, so cosmologists welcome improvements. In their latest paper, a team of astronomers including Project Assistant Professor Kenneth Wong and postdoctoral researcher Eric Paic from the University of Tokyo's Research Center for the Early Universe successfully demonstrated a method known as time-delay cosmography that they believe can mitigate the reliance on distance ladders and ought to have offshoots in other areas of cosmology as well.

Included are some cool pics of the lensed quasars used in the study.

Journal Reference:Simon Birrer, Elizabeth J. Buckley-Geer, Michele Cappellari, et al., "TDCOSMO 2025: Cosmological constraints from strong lensing time delays," Astronomy and Astrophysics: November 25, 2025, doi:10.1051/0004-6361/202555801.


Original Submission

posted by mrpg on Monday December 15, @02:11PM   Printer-friendly

https://www.wired.com/story/scientists-thought-parkinsons-was-in-our-genes-it-might-be-in-the-water/

[...] Parkinson's is the second most common neurological disease in the United States, after Alzheimer's; each year 90,000 Americans are diagnosed. For decades, Parkinson's research has focused on genetics, on finding the rogue letters in our genome that cause this incurable misery. Today, published research on the genetics behind Parkinson's outnumbers all other potential causes six to one. This is partially because one of the disease's most generous benefactors, Google cofounder Sergey Brin, can tie Parkinson's to his genetics. Some Parkinson's patients diagnosed before age 50—as Michael J. Fox was—can trace the disease to their genes; Brin, whose mother has the disease, carries a mutation of the LRRK2 gene, which significantly increases the likelihood of him developing PD. Over the years, Fox's foundation has raised billions for Parkinson's research, and Brin has personally committed $1.8 billion to fighting the disorder. All told, more than half of Parkinson's research dollars in the past two decades have flowed toward genetics.

But Parkinson's rates in the US have doubled in the past 30 years. And studies suggest they will climb another 15 to 35 percent in each coming decade. This is not how an inherited genetic disease is supposed to behave.

Despite the avalanche of funding, the latest research suggests that only 10 to 15 percent of Parkinson's cases can be fully explained by genetics. The other three-quarters are, functionally, a mystery. "More than two-thirds of people with PD don't have any clear genetic link," says Briana De Miranda, a researcher at the University of Alabama at Birmingham. "So, we're moving to a new question: What else could it be?"

"The health you enjoy or don't enjoy today is a function of your environment in the past," says Ray Dorsey, a physician and professor of neurology at the University of Rochester. Your "environment" could be the refinery a town over, the lead in the paint of your mother's home, the plastic sheath of the Hot Pocket you microwaved in 1996. It is air pollution and PFAS and pesticides and so much more.

And this environment of yours—the sum of all your exposures, from conception to the grave—could be making you sicker than you realize. In a study of half a million Britons, Oxford researchers determined that lifestyle and the environment is 10 times more likely to explain early death than genetics. But that also offers a tantalizing prospect. If Parkinson's is an environmental disease, as Dorsey and a small band of researchers emphatically believe, then maybe we can end it.


Original Submission

posted by mrpg on Monday December 15, @09:22AM   Printer-friendly

The State of Open Source Software in 2025:

A few weeks ago, Linux Foundation Research published "The State of Global Open Source 2025," the third annual report based on its survey of the open source community. The report highlights the evolution of open source software (OSS) from a productivity tool to a key component of global mission-critical infrastructures. The 2025 global survey on which it's based confirms that organizations depend on OSS as the backbone of their critical systems.

Given my long involvement with open source technologies and the Linux Foundation, I was invited to write the Foreword of the 2024 Open Source report, where I tried to explain why open source has been so successful over the past several decades:

"For centuries, experts have worked together to jointly address some of the most complex and important problems of their times, from exploring the secrets of the universe to developing new healthcare treatments. Open source is part of this long tradition of collaborative innovation."

[...] The 2025 report warns that despite open source software being the backbone of organizations' critical systems, "most lack the governance and security frameworks to manage this dependency safely. While expecting enterprise-level reliability and support, organizations systematically underinvest in the security practices, formal governance structures, community engagement, and comprehensive strategies that production environments demand. ... This governance gap creates substantial risk exposure given the mission-critical nature of these deployments."

[...] "The 2025 World of Open Source Survey reveals a paradox: while open source software has achieved mission-critical status with widespread adoption across enterprise technology stacks, organizational maturity significantly lags behind this adoption," said the report in conclusion. "This disconnect creates significant business risks: organizations depend on foundational technologies they cannot adequately assess, understand, or strategically influence."

Finally, the report offers a few key recommendations:

  • Establish open source governance structures. Implement Open Source Program Offices (OSPOs) or formalize open source strategies to manage compliance, security, and contribution workflows.
  • Strengthen security evaluation practices. Move beyond the community health checks currently used by 44% of organizations to implement systematic security assessment frameworks.
  • Establish enterprise-grade support arrangements. Organizations should establish support arrangements with sub-12-hour response times for mission-critical workloads.
  • Promote strategic participation through active engagement. Prioritize sponsoring critical open source dependencies to ensure project sustainability and gain strategic influence over technology roadmaps.

Original Submission

posted by mrpg on Monday December 15, @04:45AM   Printer-friendly
from the let-every-man-be-master-of-his-time dept.

NIST scientists have calculated that clocks on Mars will tick an average of 477 millionths of a second faster than clocks on Earth per day:

Ask someone on Earth for the time and they can give you an exact answer, thanks to our planet's intricate timekeeping system, built with atomic clocks, GPS satellites and high-speed telecommunications networks.

However, Einstein showed us that clocks don't tick at the same rate across the universe. Clocks will run slightly faster or slower depending on the strength of gravity in their environment, making it tricky to synchronize our watches here on Earth, let alone across the vast solar system. If humans want to establish a long-term presence on the red planet, scientists need to know: What time is it on Mars?

Physicists at the National Institute of Standards and Technology (NIST) have calculated a precise answer for the first time. On average, clocks on Mars will tick 477 microseconds (millionths of a second) faster than on Earth per day. However, Mars' eccentric orbit and the gravity from its celestial neighbors can increase or decrease this amount by as much as 226 microseconds a day over the course of the Martian year. These findings, just published in The Astronomical Journal, follow a 2024 paper in which NIST physicists developed a plan for precise timekeeping on the Moon.

Knowing how clocks will tick on Mars is a steppingstone for future space missions, said NIST physicist Bijunath Patla. As NASA plans Mars exploration missions, understanding time on our planetary neighbor will help synchronize navigation and communication across our solar system.

"The time is just right for the Moon and Mars," Patla said. "This is the closest we have been to realizing the science fiction vision of expanding across the solar system."

Journal Reference: Neil Ashby and Bijunath R. Patla 2026 AJ 171 2 DOI 10.3847/1538-3881/ae0c16


Original Submission