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posted by hubie on Tuesday April 25 2023, @09:13PM   Printer-friendly

Linux Foundation launches new organization to maintain TLA+:

The LinuxFoundation, the nonprofit tech consortium that manages various open source efforts, today announced the launch of the TLA+ Foundation to promote the adoption and development of the TLA+ programming language. AWS, Oracle and Microsoft are among the inaugural members.

What is the TLA+ programming language, you ask? It's a formal "spec" language developed by computer scientist and mathematician Leslie Lamport. Best known for his seminal work in distributed systems, Lamport — now a scientist at Microsoft Research — created TLA+ to design, model, document and verify software programs — particularly those of the concurrent and distributed variety.

[...] "TLA+ is unique in that it's intended for specifying a system, rather than for implementing software," a Linux Foundation spokesperson told TechCrunch via email. "Based on mathematical concepts, notably set theory and temporal logic, TLA+ allows for the expression of a system's desired correctness properties in a formal and rigorous manner."

TLA+ includes a model checker and theorem prover to verify if a system's specification satisfies its desired properties. The goal is to assist developers with reasoning about systems above the code level, uncovering and preventing design flaws (hopefully) before they evolve into bugs during the later stages of software engineering.

[...] With the establishment of the TLA+ Foundation, the Linux Foundation says it'll provide education and training resources around TLA+, fund research and develop tools for it and work to foster a community of TLA+ practitioners. The TLA+ Foundation will also make decisions on language enhancements, address user feedback and guide the language's evolution.

"TLA+ has already been successfully used by major tech companies like Amazon, Oracle, and Microsoft to verify and design planetary-scale systems," the spokesperson continued. "By establishing a TLA+ Foundation under the umbrella of the Linux Foundation, TLA+ will gain increased visibility and support, promoting its wider adoption within the tech industry. The foundation's mission to advocate for open-source projects will ensure that TLA+ continues to evolve and remain accessible to the broader tech community. Additionally, the foundation will facilitate greater collaboration between industry and academia, advancing the state of the art in formal methods and concurrent and distributed systems research."


Original Submission

posted by janrinok on Tuesday April 25 2023, @06:31PM   Printer-friendly
from the you-spin-me-right-round dept.

Next-generation silicon chips based on spintronics could improve global cybersecurity:

Imagine a movie about a rogue employee who breaches security in a company that implants chips inside half of the world's computers. They embed a Trojan in systems around the globe and hold the world to ransom.

This is not unimaginable, says Rajat Kumar, a Ph.D. student in Yehia Massoud's lab at KAUST. "A single company currently supplies more than half of the world's chips, and nearly all of the most advanced chips," he confirms.

Massoud's group researches emerging technology that could make chips more secure. A recent project reports multifunctional logic gates that offer users a range of hardware security advantages. These include better control over their devices, tamper protection, watermarking and fingerprinting, and layout camouflage.

"Even if a semiconductor foundry is highly trustworthy, an untrusted entity in the supply chain could tamper with chips," Massoud says.

[...] As a secure alternative, Kumar and colleagues explored polymorphic gates made from nanoscale structures consisting of an oxide layer sandwiched between two ferromagnetic layers. These structures, known as a magnetic tunnel junctions (MTJ), are easily switchable by reversing the relative orientation of magnetic spins of the ferromagnetic layers. This spin-based control makes MTJs examples of spintronic devices.

Kumar and colleagues thought the switchable properties of MTJs meant that they could be used to create polymorphic gates, whose configuration users could check and reconfigure, overwriting any nefarious settings. They showed that MTJs function as polymorphic gates in a way that prevents tampering and intellectual property piracy due to their symmetry at both circuit and layout level symmetry, obscuring their layout and making them hard to reverse engineer.

Journal Reference:
Kumar, R., Divyanshu, D,. Khan, et al., Y. Polymorphic hybrid CMOS-MTJ logic gates for hardware security applications. Electronics, 12, 902 (2023). DOI: https://doi.org/10.3390/electronics12040902


Original Submission

posted by janrinok on Tuesday April 25 2023, @03:47PM   Printer-friendly
from the the-idea-is-growing-on-me dept.

The fungi can regrow, potentially fixing tears in items one day made from the alternative leather:

Imagine if a ripped leather jacket could repair itself instead of needing to be replaced.

This could one day be a reality, if the jacket is fashioned from fungus, researchers report April 11 in Advanced Functional Materials. The team made a self-healing leather from mushrooms' threadlike structures called mycelium, building on past iterations of the material to allow it to fix itself.

Mycelium leather is already an emerging product, but it's produced in a way that extinguishes fungal growth. Elise Elsacker and colleagues speculated that if the production conditions were tweaked, the mycelium could retain its ability to regrow if damaged.

That novel approach could offer inspiration to other researchers trying to get into the mycelium leather market, says Valeria La Saponara, a mechanical and aerospace engineer at the University of California, Davis.

Elsacker, a bioengineer now at the Vrije Universiteit Brussel, and her colleagues first grew mycelium in a soup rich in proteins, carbohydrates and other nutrients. A skin formed on the surface of the liquid, which the scientists scooped off, cleaned and dried to make a thin, somewhat fragile leather material. They used temperatures and chemicals mild enough to form the leather but leave parts of the fungus functional. Left dormant were chlamydospores, little nodules on the mycelium that can spring back to life and grow more mycelium when conditions are prime.

After punching holes in the leather, the researchers doused the area in the same broth used to grow it to revive the chlamydospores. The mycelium eventually regrew over the punctures. Once healed, the hole-punched areas were just as strong as undamaged areas — however, the repairs were visible from one side of the leather.

Journal Reference:
DOI: https://onlinelibrary.wiley.com/doi/10.1002/adfm.202301875


Original Submission

posted by janrinok on Tuesday April 25 2023, @01:38PM   Printer-friendly

Watch ispace attempt to land on the moon for the first time:

After five long months journeying through space, ispace's Hakuto-R lander is ready to greet the lunar surface.The Japanese company is expecting to land Hakuto-R at 12:40 PM EST today. If successful, this first mission will no doubt be a huge boon for ispace's ambitious plans to send two subsequent landers to the moon in 2024 and 2025. It would also make them the first private company to land on the moon, and the first spacecraft from Japan to do so. (China, the United States, and the USSR have been the only nations to reach the lunar surface.)This first mission, appropriately named Mission 1, kicked off last December when a SpaceX Falcon 9 launched the lander into space. Since then, the lander has performed a number of maneuvers to stay on track in its path to the moon. At its farthest point, Hakuto-R traveled as much as 1.4 million kilometers from Earth.

The livestream will kick-off one hour prior to landing at 11:40 EST.

Link to stream.


Original Submission

posted by janrinok on Tuesday April 25 2023, @01:02PM   Printer-friendly

If I understand it correctly, researchers made a vaccine that targets the proteins common to all flu viruses instead of the part that changes every year. They tested it on 52 people and found it safe and effective.

A Widge, et al. An Influenza Hemagglutinin Stem Nanoparticle 1 Vaccine Induces Cross
Group 1 Neutralizing Antibodies in Healthy Adults. Science Translational Medicine https://www.science.org/doi/10.1126/scitranslmed.ade4790

S Andrews, et al. An Influenza H1 Hemagglutinin Stem-Only Immunogen Elicits a Broadly Cross-Reactive B Cell Response in Humans. Science Translational Medicine https://www.science.org/doi/10.1126/scitranslmed.ade4976

Universal Influenza Candidate Vaccine Performs Well in Phase 1 Trial NIAID Now https://www.niaid.nih.gov/news-events/vrc-uni-flu-vax

Scientists at NIAID's Vaccine Research Center (VRC) report in two new studies that an experimental influenza vaccine, designed to elicit immunity against a broad range of influenza viruses, performed well in a small trial of volunteers. In fact, the vaccine has advanced to a second trial led by scientists at Duke University through NIAID's Collaborative Influenza Vaccine Innovation Centers (CIVICs).

In a phase 1 clinical trial of 52 volunteers, the vaccine developed by the VRC – known as H1ssF (influenza H1 hemagglutinin stabilized stem ferritin nanoparticle vaccine) – was safe, well-tolerated, and induced broad antibody responses that target the hemagglutinin stem. The two new studies assessing the nanoparticle vaccine published April 19 in Science Translational Medicine.


Original Submission

posted by janrinok on Tuesday April 25 2023, @10:15AM   Printer-friendly

Linux 6.3 debuts after 'nice, controlled release cycle':

Linux 6.3 has arrived after a push that project boss Linus Torvalds characterized as "a nice, controlled release cycle" that required the seven release candidates he prefers and was supported by helpful developer behavior.

"It happens," he added, but also didn't rule out "something nasty couldn't have been lurking all these weeks." Torvalds therefore urged real-world testing to make sure this release really is ready for prime-time consumption.

Holidays and travel are often the cause of delays to kernel releases. Easter didn't slow development this time around.

Version 6.3 won't be a long term support (LTS) release – the last of those was Linux 6.1, and every fifth or sixth release gets LTS status. So while many users will be pleased to see it, 6.3 almost certainly won't be a cut of the kernel that demands adoption or attention.

Which is not to say it doesn't include some interesting goodies.

Among the additions are better support for multi-actuator hard disk drives. Conventional hard disks have one actuator driving a single set of read/write heads. Multi-actuator disks add a second set of heads, which speeds things up nicely. Hyperscale cloud operators are the first big buyers of multi-actuator disks, but they're slowly going mainstream. Now Linux is better able to handle them.

China's Loongson makes RISC-V processors and is working hard and fast to make them an enterprise contender. Linux 6.3 will help that a little by supporting Kernel Address Space Layout Randomization on the company's silicon. This has been around on other architectures for ages – security is helped by having the kernel load into different areas of memory each time it boots, instead of using the same locations and giving attackers a known target.

Microsoft coders contributed updates that add nested hypervisor support for Redmond's own Hyper-V hypervisor.


Original Submission

posted by janrinok on Tuesday April 25 2023, @07:28AM   Printer-friendly
from the to-err-is-Rattus-to-forgive-devine dept.

Both tend to judge the co-occurrence of two events as more probable than one event alone:

Animals, like humans, appear to be troubled by a Linda problem.

The famous "Linda problem" was designed by psychologists to illustrate how people fall prey to what is known as the conjunction fallacy: the incorrect reasoning that if two events sometimes occur in conjunction, they are more likely to occur together than either event is to occur alone.

[...] In the 1980s, Nobel laureate Daniel Kahneman and his colleague Amos Tvesrky showed that in a variety of scenarios, humans tend to believe, irrationally, that the intersection of two events is more probable than a single event. They asked participants to answer a question based on the following scenario.

Linda is 31 years old, single, outspoken and very bright. She majored in philosophy. As a student, she was deeply concerned with issues of discrimination and social justice and also participated in anti-nuclear demonstrations.

Which is more probable?

  1. Linda is a bank teller
  2. Linda is a bank teller and is active in the feminist movement

The great majority of participants chose No. 2, although logically it is less probable than Linda being a bank teller alone. After all, No. 1 would not preclude Linda from also being an active feminist, but given the description of Linda, No. 2 may be easier for respondents to imagine.

The Linda problem and numerous similar studies seem to indicate that humans estimate the likelihood of an event using mental shortcuts, assessing how similar the event is to a model they already have in their minds. [...]

To determine whether the fallacy necessarily involves language and whether it is unique to humans, González engaged rats in a physical, not social, task. With psychology professor Aaron Blaisdell, she designed two experiments that required the rats to judge the likelihood of just a sound being present or both a light and sound being present in order to receive a food reward.

[...] The tendency to overestimate the likelihood that both sound and light were present, even if it meant no reward, demonstrates that, like humans, rats can show a conjunction fallacy, the authors said.

"Until now, researchers said this is unique to human cognition only because we haven't looked for it in animals," Blaisdell said. "If humans and other animals consider alternative states of the world during ambiguous situations to help decision-making, we might expect systematic biases such as the conjunction fallacy to show a broader distribution in the animal kingdom."

Journal Reference:
González, V.V., Sadeghi, S., Tran, L. et al. The conjunction fallacy in rats [open]. Psychon Bull Rev (2023). https://doi.org/10.3758/s13423-023-02251-z


Original Submission

posted by hubie on Tuesday April 25 2023, @04:43AM   Printer-friendly
from the another-one-goes-down dept.

The move came as its parent company, BuzzFeed Inc., seeks further cost cuts:

BuzzFeed News is shutting down.

In an email to staff shared with NBC News, BuzzFeed CEO Jonah Peretti said the move was part of a 15% workforce reduction across a number of teams.

"While layoffs are occurring across nearly every division, we've determined that the company can no longer continue to fund BuzzFeed News as a standalone organization," he wrote.

Peretti said he had "overinvest[ed] in BuzzFeed News "because I love their work and mission so much."

"This made me slow to accept that the big platforms wouldn't provide the distribution or financial support required to support premium, free journalism purpose-built for social media," he wrote.

He added that he had failed to "hold the company to higher standards for profitability" to give it a buffer for downturns.

Moving forward, BuzzFeed will have a lone news brand, HuffPost, which BuzzFeed acquired in 2020 and which Peretti said "is profitable, with a loyal direct front page audience."

[...] BuzzFeed News launched in earnest at the outset of 2012 after it named longtime New York City political reporter Ben Smith as its editor-in-chief. In 2021, the news organization won a Pulitzer Prize for a series exposing China's mass detention of Muslims. That same year, it was also named a Pulitzer finalist — the second time it had received the honor.

Later that year, BuzzFeed Inc. became a publicly traded company amid a global frenzy of reverse mergers, many of which have since lost significant value. In BuzzFeed's case, it never traded above its initial public offering price of about $10.


Original Submission

posted by mrpg on Tuesday April 25 2023, @01:56AM   Printer-friendly
from the this-wouldn't-happen-with-openai dept.

Autonomous cars confused by San Francisco's fog:

Driving in thick fog is a big enough challenge for humans, but it turns out self-driving cars find it pretty tricky, too.

Overwhelmed by dense fog in San Francisco early on Tuesday morning, five of Waymo's fully driverless vehicles suddenly parked by the side of a residential street in what appeared to be a precautionary measure, the San Francisco Chronicle reported. Another of its cars apparently came to halt in the middle of the street, the news outlet said.

Other vehicles were unable to pass as "baffled motorists flashed headlights and tried to maneuver around the jam," the Chronicle said.

The traffic problems persisted until the fog cleared and the autonomous cars were able to resume their journeys.


Original Submission

posted by mrpg on Monday April 24 2023, @11:15PM   Printer-friendly

Three small regions unexpectedly connect to a network known for planning and pain perception:

The classical view of how the human brain controls voluntary movement might not tell the whole story.

That map of the primary motor cortex — the motor homunculus — shows how this brain region is divided into sections assigned to each body part that can be controlled voluntarily (SN: 6/16/15). It puts your toes next to your ankle, and your neck next to your thumb. The space each part takes up on the cortex is also proportional to how much control one has over that part. Each finger, for example, takes up more space than a whole thigh.

A new map reveals that in addition to having regions devoted to specific body parts, three newfound areas control integrative, whole-body actions. And representations of where specific body parts fall on this map are organized differently than previously thought, researchers report April 19 in Nature.


Original Submission

posted by janrinok on Monday April 24 2023, @08:34PM   Printer-friendly

Babies tumble about with more than 200 previously unknown viral families within their intestines:

Viruses are usually associated with illness. But our bodies are full of both bacteria and viruses that constantly proliferate and interact with each other in our gastrointestinal tract. While we have known for decades that gut bacteria in young children are vital to protect them from chronic diseases later on in life, our knowledge about the many viruses found there is minimal.

A few years back, this gave University of Copenhagen professor Dennis Sandris Nielsen the idea to delve more deeply into this question. As a result, a team of researchers from COPSAC (Copenhagen Prospective Studies on Asthma in Childhood) and the Department of Food Science at UCPH, among others, spent five years studying and mapping the diaper contents of 647 healthy Danish one-year-olds.

"We found an exceptional number of unknown viruses in the faeces of these babies. Not just thousands of new virus species – but to our surprise, the viruses represented more than 200 families of yet to be described viruses. This means that, from early on in life, healthy children are tumbling about with an extreme diversity of gut viruses, which probably have a major impact on whether they develop various diseases later on in life," says Professor Dennis Sandris Nielsen of the Department of Food Science, senior author of the research paper about the study, now published in Nature Microbiology.

The researchers found and mapped a total of 10,000 viral species in the children's faeces – a number ten times larger than the number of bacterial species in the same children. These viral species are distributed across 248 different viral families, of which only 16 were previously known. The researchers named the remaining 232 unknown viral families after the children whose diapers made the study possible. As a result, new viral families include names like Sylvesterviridae, Rigmorviridae and Tristanviridae.

[...] Ninety percent of the viruses found by the researchers are bacterial viruses – known as bacteriophages. These viruses have bacteria as their hosts and do not attack the children's own cells, meaning that they do not cause disease. The hypothesis is that bacteriophages primarily serve as allies:

"We work from the assumption that bacteriophages are largely responsible for shaping bacterial communities and their function in our intestinal system. Some bacteriophages can provide their host bacterium with properties that make it more competitive by integrating its own genome into the genome of the bacterium. When this occurs, a bacteriophage can then increase a bacterium's ability to absorb e.g. various carbohydrates, thereby allowing the bacterium to metabolise more things," explains Dennis Sandris Nielsen, who continues:

[...] The remaining ten percent of viruses found in the children are eukaryotic – that is, they use human cells as hosts. These can be both friends and foes for us:

"It is thought-provoking that all children run around with 10-20 of these virus types that infect human cells. So, there is a constant viral infection taking place, which apparently doesn't make them sick. We just know very little about what's really at play. My guess is that they're important for training our immune system to recognise infections later. But it may also be that they are a risk factor for diseases that we have yet to discover," says Dennis Sandris Nielsen.

Journal Reference:
Shah, S.A., Deng, L., Thorsen, J. et al. Expanding known viral diversity in the healthy infant gut [open]. Nat Microbiol (2023). https://doi.org/10.1038/s41564-023-01345-7


Original Submission

posted by janrinok on Monday April 24 2023, @05:50PM   Printer-friendly

Perhaps not all booms are bad:

About four minutes after SpaceX's gargantuan rocket lifted from its Texas launch pad, it burst into a fireball over the Gulf of Mexico, never reaching space.

Though SpaceX hasn't shared many details yet about what happened during Starship's maiden voyage, one fact is known: It was intentionally ordered to explode.

Rockets are destroyed in the air when people's lives could be even remotely at risk of falling debris. In the days since the uncrewed test, no injuries or major property damage appear to have been reported.

When the rocket launched at 9:33 a.m. ET April 20, 2023, some of the rocket's 33 booster engines had either burned out or failed to light from the start. As Starship ascended, cameras caught views of the flames underneath it, appearing to show some of the engines had cut out.

In a statement released after the incident, SpaceX said Starship climbed to about 26 miles over the ocean before beginning to lose altitude and tumble. Then, self-destruct commands were sent to the booster and ship, which hadn't separated as planned, the company said.

What ultimately initiated that disintegration isn't completely clear, Dan Dumbacher, executive director of the American Institute of Aeronautics and Astronautics, told Mashable.

"Now it's a pure race as to whether the aerodynamic pressure breaks the vehicle up or the flight termination system does," he said, "but it really doesn't matter because the end result is the same."

As Starship ascended, cameras caught views of the array of flames underneath it, appearing to show some of the engines were out.

"There's a lot of risk associated with this first launch, so I would not say that it is likely to be successful," [Elon Musk] said during a video conference with a National Academies panel in 2021. "But I think we will make a lot of progress."

Despite Starship never having reached space, industry experts largely regarded the launch as a partial success because the rocket managed to clear the launch tower and traveled higher than any Starship prototype had before.

Meanwhile, the general public seemed unsure of how to think of the whole thing: After all, usually, when something big and expensive goes boom, it's considered bad. But SpaceX has always approached rocketry differently from NASA, working a little messier and faster to achieve its goals.

In terms of the explosive ending, Dumbacher said spaceport safety officers are required to terminate a flight if a rocket meanders into an area where the risk of debris hitting someone on the ground could exceed a probability of one in 30 million. "People ought to be looking at this as good — the flight termination system, if it was needed, actually worked," he said.


Original Submission

posted by janrinok on Monday April 24 2023, @03:05PM   Printer-friendly
from the burning-questions dept.

Likely a motherboard BIOS issue:

High-performance microprocessors tend to get hot and, when overclocked without proper cooling or throttling, can literally burn out When an old CPU does so in an old PC because of dust and a worn out fan, there is nothing surprising about it. But when a new CPU breaks on a shiny new motherboard, that's surprising. This is what happened to an AMD Ryzen 7 7800X3D, one of the best CPUs, which belonged to a Reddit user. And, according to other users, he's not alone.

"The CPU pad is physically bulging," wrote Speedrookie, the owner of the burned-out processor. "I imagine there was just too much heat on the contacts causing the pad to expand. Not that the CPU has an internal component which exploded."

At least when it comes to AMD's Ryzen 7000X3D-series processors, it appears that this is by far not an isolated case. There are reports from other Reddit users who had the same experience with their Ryzen 7000X3D CPUs on motherboards from Asus and MSI.

Famous overclocker der8auer also had an issue with an AMD Ryzen 7000X3D chip burning out during some early overclocking tests a few weeks ago. As you can see in his video, he says "I did not expect this to happen so quickly and especially right out of the BIOS."

There are about a million of reasons why a modern processor can burn out. Defective sockets or a motherboards [sic] are likely causes and insufficient cooling can cause a similar result. A BIOS version that tends to automatically overclock CPUs too much could be a yet another reason for a processor failure. In fact, as noticed by HXL (@9550pro), Asus has just withdrew old BIOSes for many of its AMD X670-based motherboards, but for some of them old BIOSes are still available.

[...] Again, given that the information is insufficient to say the least, we cannot make any conclusions at this point. We'll reach out to our contacts at AMD and the motherboard vendors to see if they are aware of any issues. For now, we recommend that those with AMD's Ryzen 7000X3D processors keep a close eye on their CPU temps, use adequate cooling and keep their BIOSes up-to-date.


Original Submission

posted by janrinok on Monday April 24 2023, @12:21PM   Printer-friendly

A recent experiment tested the mass-based boundaries between the quantum and classical realms:

Picture a cat. I'm assuming you're imagining a live one. It doesn't matter. You're wrong either way—but you're also right. This is the premise of Erwin Schrödinger's 1935 thought experiment to describe quantum states, and now, researchers have managed to create a fat (which is to say, massive) Schrödinger cat, testing the limits of the quantum world and where it gives way to classical physics.

Schrödinger's experiment is thus: A cat is in a box with a poison that is released from its container if an atom of a radioactive substance, also in the box, decays. Because it is impossible to know whether or not the substance will decay in a given timeframe, the cat is both alive and dead until the box is opened and some objective truth is determined. [...]

In the same way, particles in quantum states (qubits, if they're being used as bits in a quantum computer) are in a quantum superposition (which is to say, both "alive" and "dead") until they're measured, at which point the superposition breaks down. Unlike ordinary computer bits that hold a value of either 0 or 1, qubits can be both 0 and 1 simultaneously.

Now, researchers made a Schrödinger's cat that's much heavier than those previously created, testing the muddy waters where the world of quantum mechanics gives way to the classical physics of the familiar macroscopic world. Their research is published this week in the journal Science.

In the place of the hypothetical cat was a small crystal, put in a superposition of two oscillation states. The oscillation states (up or down) are equivalent to alive or dead in Schrödinger's thought experiment. A superconducting circuit, effectively a qubit, was used to represent the atom. The team coupled electric-field creating material to the circuit, allowing its superposition to transfer over to the crystal. Capiche?

"By putting the two oscillation states of the crystal in a superposition, we have effectively created a Schrödinger cat weighing 16 micrograms," said Yiwen Chu, a physicist at ETH Zurich and the study's lead author, in a university release.

16 micrograms is roughly equivalent to the mass of a grain of sand, and that's a very fat cat on a quantum level. It's "several billion times heavier than an atom or molecule, making it the fattest quantum cat to date," according to the release. It's not the first time physicists have tested whether quantum behaviors can be observed in classical objects. Last year, a different team declared they had quantum-entangled a tardigrade, though a number of physicists told Gizmodo that claim was poppycock.

This is slightly different, as the recent team was just testing the mass of an object in a quantum state, not the possibility of entangling a living thing. While that's not in the team's plans, working with even larger masses "will allow us to better understand the reason behind the disappearance of quantum effects in the macroscopic world of real cats," Chu said.

[...] As for the true boundary between the two worlds? "No one knows," wrote Matteo Fadel, a physicist at ETH Zurich and a co-author of the paper, in an email to Gizmodo. "That's the interesting thing, and the reason why demonstrating quantum effects in systems of increasing mass is so groundbreaking."

The new research takes Schrödinger's famous thought experiment and gives it some practical applications. Controlling quantum materials in superposition could be useful in a number of fields that require very precise measurements; for example, helping reduce noise in the interferometers that measure gravitational waves.

The quantum world ripe for new discoveries, but alas, it's crammed full of unknowables, dead ends, and vexing new problems.

Journal Reference: (DOI: https://www.science.org/doi/10.1126/science.adf7553)


Original Submission

posted by janrinok on Monday April 24 2023, @09:34AM   Printer-friendly

The lineage had not been seen in the area for over two years:

[...] SARS-CoV-2 infections in mink aren't particularly noteworthy or concerning on their own; it's well established that mink are susceptible to the virus. The realization early in the pandemic resulted in extensive culls in Denmark and the Netherlands during 2020 and led to intensive monitoring and regulation of remaining mink herds in many places, including Poland.

But the recent cases in Polish mink, reported this week in the journal Eurosurveillance, are unusual. While previous mink outbreaks have linked to infected farmworkers and local circulation of the virus—indicating human-to-mink spread—none of the farm workers or families in the recently affected farms tested positive for the virus. In fact, health investigators found that the infected mink carried a strain of SARS-CoV-2 that has not been seen in humans in the region in more than two years (B.1.1.307).

The finding suggests that humans were not responsible for infecting the mink—at least not directly. Rather, it suggests that another unknown species may have been stealthily harboring and spreading the otherwise bygone strain for some time and managed to carry it onto the mink farms.

The suggestion raises more concern over viral "spillback." The term relates to the more recognized "spillover," when a virus jumps from a host population—a reservoir—to a new population, such as humans. SARS-CoV-2 is thought to have originated in a reservoir of horseshoe bats before it reached humans. Since then, it is clear that it can also infect a broad range of animals, including rodents, cats, dogs, white-tail deer, non-human primates, as well as ferrets and mink. Researchers fear that the virus could spill back to an animal population that could become a new reservoir from which the virus could periodically move back to humans.

[...] The farmed mink in Poland again highlight the risk of spillbacks by suggesting an unknown reservoir of SARS-CoV-2 in wild animals. In an investigation, researchers at National Veterinary Research Institute and Erasmus University Medical Centre looked into cases at three farms within 8 km (about 5 miles) of each other. The first farm reported two infected mink (out of 15 tested and about 8,650 animals total) on September 19, but they subsequently tested negative and were pelted as scheduled. On November 16, a second farm with 4,000 mink reported six infected animals out of 15 tested, and they were pelted with precautions. The third farm, with 1,100 mink, found 15 infected animals out of 15 tested on January 18, but they subsequently tested negative in two rounds of testing within 50 days. All of the infected animals on the three farms were asymptomatic.

The researchers obtained eight whole genome sequences—four each from the second and third farms; there wasn't enough genetic material in samples from the first farm. The genome sequences showed they were nearly identical and most closely matched the lineage B.1.1.307, which hadn't been seen in humans in Poland in over two years. The viruses also had 40 small genetic mutations, some of which have previously been associated with circulation in mink, and could have been acquired quickly. None of the farm families or workers tested positive for SARS-CoV-2 at any of the three farms.

The researchers noted that all three farms had concrete fences 1.8 meters (6 feet) high and about 30–40 cm (around a foot) deep. There was no evidence of animals burrowing under the fences, but the researchers noted overhanging tree branches that could have created a route for wild animals. Interviews with owners and staff revealed that the farms were occasionally visited by wild martens, weasel-like carnivores. And there were also feral cats around. The researchers tested feral cat droppings around the farms but found they were negative for SARS-CoV-2.


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