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Idiosyncratic use of punctuation - which of these annoys you the most?

  • Declarations and assignments that end with }; (C, C++, Javascript, etc.)
  • (Parenthesis (pile-ups (at (the (end (of (Lisp (code))))))))
  • Syntactically-significant whitespace (Python, Ruby, Haskell...)
  • Perl sigils: @array, $array[index], %hash, $hash{key}
  • Unnecessary sigils, like $variable in PHP
  • macro!() in Rust
  • Do you have any idea how much I spent on this Space Cadet keyboard, you insensitive clod?!
  • Something even worse...

[ Results | Polls ]
Comments:50 | Votes:94

posted by janrinok on Saturday January 13 2024, @09:55PM   Printer-friendly

Which countries back South Africa's genocide case against Israel at ICJ?:

The International Court of Justice (ICJ) based in The Hague [heard] its first hearing in South Africa's genocide case against Israel on Thursday, with several countries welcoming the move amid a global chorus for a ceasefire in Gaza.

South Africa filed the lawsuit end of December, accusing Israel of genocide in its war on Gaza and seeking a halt to the brutal military assault that has killed more than 23,000 Palestinians, nearly 10,000 of them children.

The 84-page filing by South Africa says Israel violated the 1948 Genocide Convention, drawn up in the aftermath of World War II and the Holocaust.

Both Israel and South Africa are signatories to the United Nations Genocide Convention, which gives the ICJ – the highest UN legal body – jurisdiction to rule on disputes over the treaty.

All states that signed the convention are obliged to not commit genocide and also to prevent and punish it. The treaty defines genocide as "acts committed with intent to destroy, in whole or in part, a national, ethnical, racial or religious group".

[...] The ICC and the ICJ are sometimes conflated with one another. Both the courts are located in The Hague, Netherlands. While the purpose of the ICJ is to resolve conflicts between states, the ICC prosecutes individuals for committing crimes, according to the University of Melbourne's Pursuit platform. While states cannot be sued at the ICC, the prosecutor can open an investigation where crimes, including genocide, were likely committed.

The United States has voiced its opposition to the genocide case. National security spokesperson John Kirby called South Africa's submission "meritless, counterproductive, and completely without any basis" during a White House press briefing on January 3.

Israeli President Isaac Herzog told US Secretary of State Antony Blinken on Tuesday that "there is nothing more atrocious and preposterous" than the lawsuit. Herzog also thanked Blinken for Washington's support of Israel.

Israel's Western allies, including the European Union, have mostly maintained silence on the ICJ case.

The United Kingdom, which has refused to support the case, has been accused of double standards after it submitted detailed legal documents to the ICJ about a month ago to support claims that Myanmar committed genocide against the Rohingya community.


Original Submission

posted by janrinok on Saturday January 13 2024, @05:10PM   Printer-friendly

https://medicalxpress.com/news/2024-01-ancient-dna-reveals-high-multiple.html

Researchers have created the world's largest ancient human gene bank by analyzing the bones and teeth of almost 5,000 humans who lived across western Europe and Asia up to 34,000 years ago.

By sequencing ancient human DNA and comparing it to modern-day samples, the international team of experts mapped the historical spread of genes—and diseases—over time as populations migrated.

The 'astounding' results have been revealed in four trailblazing research papers published (10 January 2024) in the same issue of Nature and provide new biological understanding of debilitating disorders.

The extraordinary study involved a large international team led by Professor Eske Willerslev at the Universities of Cambridge and Copenhagen, Professor Thomas Werge at the University of Copenhagen, and Professor Rasmus Nielsen at University of California, Berkeley and involved contributions from 175 researchers from around the globe.

The scientists found:

  • The startling origins of neurodegenerative diseases including multiple sclerosis
  • Why northern Europeans today are taller than people from southern Europe
  • How major migration around 5,000 years ago introduced risk genes into the population in north-western Europe—leaving a legacy of higher rates of MS today
  • Carrying the MS gene was an advantage at the time as it protected ancient farmers from catching infectious diseases from their sheep and cattle
  • Genes known to increase the risk of diseases such as Alzheimer's and type 2 diabetes were traced back to hunter gatherers
  • Future analysis is hoped to reveal more about the genetic markers of autism, ADHD, schizophrenia, bipolar disorder, and depression

Northern Europe has the highest prevalence of MS in the world. A new study has found the genes that significantly increase a person's risk of developing MS were introduced into north-western Europe around 5,000 years ago by sheep and cattle herders migrating from the east.


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posted by janrinok on Saturday January 13 2024, @12:24PM   Printer-friendly
from the rightie-tightie-lefty-loosie dept.

The two fasteners from the sampler head haven't budged for nearly 4 months, keeping the precious material inside:

The final hurdle to retrieving the full sample of asteroid Bennu collected by OSIRIS-REx – the first asteroid return sample in US history – has at last been overcome. NASA technicians have been able to successfully remove the two fasteners from the sampler head that have been preventing them from opening the canister fully since September. This canister opening has to be conducted under the most pristine conditions to not contaminate the sample, so this was quite the issue. Now, NASA can get to the pristine material from asteroid Bennu.

Since they could just take a circular saw and cut through it, once they realized two of the 35 fasteners couldn't be removed with the available and approved tools, researchers had to develop new tools that would do the job.

"Our engineers and scientists have worked tirelessly behind the scenes for months to not only process the more than 70 grams of material we were able to access previously, but also design, develop, and test new tools that allowed us to move past this hurdle," Eileen Stansbery, division chief for ARES (Astromaterials Research and Exploration Science) at NASA's Johnson Space Center, said in a statement.

"The innovation and dedication of this team has been remarkable. We are all excited to see the remaining treasure OSIRIS-REx holds."

The new tools were made of a specific grade of surgical, non-magnetic stainless steel; the hardest metal approved for use in the pristine curation gloveboxes. Before it was used on the precious container it was tested in the rehearsal lab.

"In addition to the design challenge of being limited to curation-approved materials to protect the scientific value of the asteroid sample, these new tools also needed to function within the tightly-confined space of the glovebox, limiting their height, weight, and potential arc movement," said Dr Nicole Lunning, OSIRIS-REx curator at Johnson.

"The curation team showed impressive resilience and did incredible work to get these stubborn fasteners off the TAGSAM head so we can continue disassembly. We are overjoyed with the success."


Original Submission

posted by hubie on Saturday January 13 2024, @07:38AM   Printer-friendly

Arthur T Knackerbracket has processed the following story:

Artificial intelligence can accelerate the process of finding and testing new materials, and now researchers have used that ability to develop a battery that is less dependent on the costly mineral lithium.

Lithium-ion batteries power many devices that we use every day as well as electric vehicles. [...] Finding a replacement for this crucial metal could be costly and time-consuming, requiring researchers to develop and test millions of candidates over the course of years. Using AI, Nathan Baker at Microsoft and his colleagues accomplished the task in months. They designed and built a battery that uses up to 70 per cent less lithium than some competing designs.

The researchers focused on a type of battery that only contains solid parts, and they looked for new materials for the battery component that electric charges move through, called the electrolyte. They started with 23.6 million candidate materials designed by tweaking the structure of established electrolytes and swapping out some lithium atoms for other elements. An AI algorithm then eliminated the materials that it calculated would be unstable, as well as those in which the chemical reactions that make batteries work would be weak. The researchers also considered how each material would behave while the battery was actively working. After only a few days, their list contained just a few hundred candidates, some of which had never been studied before.

[...] His team built a working battery with this material, albeit with a lower conductivity than similar prototypes that use more lithium. Baker and Murugesan both say that lots of work is left to optimise the new battery. However, the process of making it – from the first time Murugesan spoke to the Microsoft team to the battery being functional enough to turn on a light bulb – took about nine months.

"The methods here are bleeding edge, in terms of machine learning tools, but what really elevates this is that things got made and tested," says Rafael Gómez-Bombarelli at the Massachusetts Institute of Technology, who was not involved with the project. "It's very easy to do predictions; it's hard to convince someone to invest on actual experiments." He says that the team used AI to accelerate and augment calculations that physicists have been doing for decades. But this approach may still run into obstacles in the future. The data needed to train the AI for this type of work is often sparse, and materials other than battery components may require a more complex way of combining elements, he says.

Reference: arXiv arxiv.org/abs/2401.04070


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posted by hubie on Saturday January 13 2024, @02:52AM   Printer-friendly
from the in-other-words-we-have-no-idea dept.

Arthur T Knackerbracket has processed the following story:

The PC industry has ended a two-year run of declining shipments, by growing 0.3 percent in Q4 of 2023, amid a warning that the cost of components will rise this year, as will the cost of laptops and desktops.

This is according to analyst Gartner's figures, but other analysts have a different view of proceedings: IDC reckons this was the eighth straight quarter of "sales-out" shrinkage - meaning sales to retailers and distributors - and Canalys estimates the market actually grew three percent.

We've chosen on this occasion to go down the middle and mostly focus on the data emitted by number crunchers at Gartner, which calculates that some 63.37 million PCs were shipped in the three months.

“The PC market has hit the bottom of its decline after significant adjustment," said Mikako Kitagawa, director analyst at Gartner. "Inventory was normalized in the fourth quarter of 2023, which had been plaguing the industry for two years.

[...] Over at IDC, the analyst estimates that PC shipments were down 2.7 percent to 67.1 million, and also said the market has "bottomed out." Canalys was more bullish, and reckons shipments were up three percent to 65.3 million.

Things certainly seem to be improving but those heady days of the pandemic, when the total available market swelled to 350 million in 2021, seem like a long time ago.


Original Submission

posted by hubie on Friday January 12 2024, @10:08PM   Printer-friendly

https://medicalxpress.com/news/2024-01-mind-brains-built-grammar.html

For centuries, a prevailing theory in philosophy has asserted that at birth the human mind is a blank slate. More recently, the same notion has also held sway in the field of neurobiology, where it is commonly held that neural connections are slowly created from scratch with the accumulation of sensory information and experience.

Eventually, the theory goes, this allows us to create memories in space and time and to then learn from those experiences.

But after spending more than a decade studying activity in the hippocampus, the area of brain which forms memory, Yale's George Dragoi began to have his doubts.

In his research on the hippocampus of rodents, Dragoi, an associate professor of psychiatry and of neuroscience, has found that early in life there emerge in this part of the brain individual functional clusters of cells (and, soon after, short sequences of cells) that predictably will be activated by new experiences. Within days of birth, he found, these cells, clusters, and short sequences become the foundation for increasingly complex sequences of cell assemblies that allow for the creation of memories.

In a new article published in the journal Nature Reviews Neuroscience, Dragoi makes the case that the human brain also develops a cellular template soon after birth which defines who we are and how we perceive the world. He describes it as "the generative grammar" of the brain.

"Neurons organize like letters, then words, then sentences and paragraphs which allow for the internalization of the outside world," Dragoi said. "The brain has its own built-in sense of grammar."

The idea, he admits, runs counter to the tenets of empiricism, a centuries-old theory that all knowledge is derived from sensory experience. It also contradicts widely held assumption by life scientists that environmental stimuli will entirely dictate how the brain processes and stores information.

Journal Reference:
Dragoi, G. The generative grammar of the brain: a critique of internally generated representations. Nat. Rev. Neurosci. 25, 60–75 (2024). https://doi.org/10.1038/s41583-023-00763-0


Original Submission

posted by hubie on Friday January 12 2024, @05:24PM   Printer-friendly
from the can-we-crush-AI-instead? dept.

Media outlets are calling foul play over AI companies using their content to build chatbots. They may find friends in the Senate:

Logo text More than a decade ago, the normalization of tech companies carrying content created by news organizations without directly paying them — cannibalizing readership and ad revenue — precipitated the decline of the media industry. With the rise of generative artificial intelligence, those same firms threaten to further tilt the balance of power between Big Tech and news.

On Wednesday, lawmakers in the Senate Judiciary Committee referenced their failure to adopt legislation that would've barred the exploitation of content by Big Tech in backing proposals that would require AI companies to strike licensing deals with news organizations.

Richard Blumenthal, Democrat of Connecticut and chair of the committee, joined several other senators in supporting calls for a licensing regime and to establish a framework clarifying that intellectual property laws don't protect AI companies using copyrighted material to build their chatbots.

[...] The fight over the legality of AI firms eating content from news organizations without consent or compensation is split into two camps: Those who believe the practice is protected under the "fair use" doctrine in intellectual property law that allows creators to build upon copyrighted works, and those who argue that it constitutes copyright infringement. Courts are currently wrestling with the issue, but an answer to the question is likely years away. In the meantime, AI companies continue to use copyrighted content as training materials, endangering the financial viability of media in a landscape in which readers can bypass direct sources in favor of search results generated by AI tools.

[...] A lawsuit from The New York Times, filed last month, pulled back the curtain behind negotiations over the price and terms of licensing its content. Before suing, it said that it had been talking for months with OpenAI and Microsoft about a deal, though the talks reached no such truce. In the backdrop of AI companies crawling the internet for high-quality written content, news organizations have been backed into a corner, having to decide whether to accept lowball offers to license their content or expend the time and money to sue in a lawsuit. Some companies, like Axel Springer, took the money.

It's important to note that under intellectual property laws, facts are not protected.

Also at Courthouse News Service and Axios.

Related:


Original Submission

posted by hubie on Friday January 12 2024, @12:41PM   Printer-friendly

The OpenWRT project is turning 20 years old this year. During that time they have adapted to existing hardware products. Now the team has the idea to produce their own, fully supported hardware to run their software on:

It is not [a] new [idea]. We first spoke about this during the OpenWrt Summits in 2017 and also 2018. It became clear start of December 2023 while tinkering with Banana Pi style devices that they are already pretty close to what we wanted to achieve in '17/'18. Banana PIs have grown in popularity within the community. They boot using a self compiled Trusted Firmware-A (TF-A)and upstream U-Boot (thx MTK/Daniel) and some of the boards are already fully supported by the upstream Linux kernel. The only nonopen sourcecomponents are the 2.5 GbE PHYandWi-Fi firmware blobsrunning on separate cores that areindependent of the main SoC running Linuxand the DRAM calibration routines which are executed early during boot.

I contacted three project members (pepe2k, dangole, nbd) on December 6th to outline the overall idea. We went over several design proposals, At the beginning we focused on the most powerful (and expensive) configurations possible but finally ended up with something rather simple and above all,feasible. We would like to propose the following as our "first" community driven HW platform called "OpenWrt One/AP-24.XY".

Together with pepe2k (thx a lot) I discussed this for many hours and we worked out the following project proposal. Instead of going insane with specifications, we decided to include some nice features we believe all OpenWrt supported platforms should have (e.g. being almost unbrickablewith multiple recovery options, hassle-free system console access, on-board RTC with battery backup etc.).

This is our first design, so let's KiSS!

The preliminary hardware specifications are included in the message and it will contain a pair of flash chips for redundancy with the aim to make the router harder to accidentally brick during an update.

Previously:
(2021) The Accident which Made the WRT54G Legendarily Popular
(2018) Reunited with LEDE, OpenWrt Releases Stable 18.06 Version
(2015) OpenWrt Gets Update in Face of FCC's Anti-Flashing Push


Original Submission

posted by hubie on Friday January 12 2024, @08:00AM   Printer-friendly

Arthur T Knackerbracket has processed the following story:

The belief that all fingerprints are unique is so well accepted that crime novels and TV shows riff on it. Recent AI research has challenged this notion, at least regarding the fingerprints on different fingers of the same person.

Undergrad researchers at Columbia Engineering found that while the branching and endpoints in the fingerprint ridges might vary, the angles and curvature at the center of the fingerprint could be the same across an individual.

To determine this, the students used a deep contrastive network and a US government database of 60,000 fingerprints to study commonalities in fingerprints. They fed pairs of prints to a neural network, with some coming from the same person and others from different individuals.

The network eventually became able to identify if prints were from the same person to an accuracy of 77 percent. That accuracy increased when multiple pairs of prints were presented.

The team initially had no idea how the network was able to identify whether the prints belonged to the same person. To the human eye, the fingerprints certainly did not appear similar.

In order to understand that it was merely identifying the angles and starting points of the ridges, they had to study the AI system's decision process. Thus, the team concluded that the AI was using an unexpected forensic marker.

As it turns out, humans can be so set in their processes not only when it comes to identifying prints but also identifying science. The first journal the team submitted their results to rejected them with the conclusion: "It is well known that every fingerprint is unique," according to the university.


Original Submission

posted by hubie on Friday January 12 2024, @03:15AM   Printer-friendly
from the massive-dumpster-fire dept.

One of the Windows updates in the current cycle is for KB5034441, which addresses CVE-2024-20666. From what I can tell, exploiting this vulnerability requires physical access, so there's no risk of this being used in remote attacks. The actual risk to most users is probably very low. Still, it allows security features to be bypassed, so it should be fixed.

The problem is that this update is failing for many users with error code 0x80070643. Microsoft claims that this is due to the recovery partition not being large enough on some systems, though the error code is cryptic and unhelpful. Here's what Microsoft said about that:

Known issue Because of an issue in the error code handling routine, you might receive the following error message instead of the expected error message when there is insufficient disk space:

        0x80070643 - ERROR_INSTALL_FAILURE

Windows isn't even telling users the correct error. Microsoft claims the update is failing on systems where the recovery partition isn't large enough. From my own experience, I have systems where I allowed the Windows installer to partition the drive automatically, meaning that Windows determined the size of the recovery partition. Windows 10 chose a size of 509 MB on my systems, and this doesn't seem to be scaled depending on the size of the user's drive. For most users, this is probably set automatically by the installer or the computer manufacturer. That said, I've read a user comment that the update failed on a system with a 15 GB recovery partition, so I'm not certain that this can really be blamed on insufficient disk space.

Microsoft's advice to users is that they need to manually resize the recovery partition. The commands are not intuitive, and there's absolutely no reason that Microsoft should be expecting ordinary users to be doing this. Resizing partitions is a fairly high risk operation, one that carries a risk of data loss if not done properly.

This vulnerability probably just isn't a risk at all for most users, but that's not necessarily obvious. They just see the message that a security update failed with a cryptic error message. It's Microsoft's responsibility to ensure that security updates just work when they're being installed on a system in a reasonably standard configuration. If the Windows installer chose a recovery partition of 509 MB, then Microsoft needs to make their updates work with a recovery partition of that size, or they need to automatically resize the partition. This is a dumpster fire, and it's inexcusable to expect Microsoft to expect users to manually repartition their drives.


Original Submission

posted by hubie on Thursday January 11 2024, @10:31PM   Printer-friendly

https://phys.org/news/2024-01-eco-friendly-fungicide-alternative.html

A material that could replace current fungicides (i.e., anti-fungal pesticides), increase food security, and help protect wildlife has been discovered.

A recent investigation undertaken by Pesticide Action Network (PAN) revealed that the UK is still using 36 harmful pesticides that have been banned in other European countries, with 13 described as "highly hazardous" that have links to water contamination, cancer, infertility, and other illnesses.

Published in Green Chemistry, researchers at the University of Nottingham have completed a successful field trial of a material they have developed to help to protect crops from fungi.

Simon Avery, professor of eukaryotic microbiology in the Faculty of Medicine and Health Sciences, said, "The test material is not toxic but works by passively resisting attachment of fungal spores to protect surfaces from fungal infection, including crop surfaces. Results from this first field trial with wheat are particularly encouraging as there is a lot of scope to optimize further the material properties for crop protection."

"We identified two lead polymer candidates by bio-performance testing using in vitro microplates and leaf-based assays. These were then taken forward into a program to optimize and scale up their synthesis and compound them into a spray formulation that could be used on crops. Our findings showed that the material not only significantly reduced fungal infection by the fungus Septoria tritici by up to 26% but also that the crop grew just as well as the control group—providing an alternative that appears safer for the environment, wildlife, and people, and is effective, too."

Sprayed directly onto wheat at timings conventional for fungicides, the trial has provided the first real-world scale exemplification of how the material interacts with crops. The small plot trial compared the two polymer candidates to a multisite fungicide and two commercial fungicide programs.

[...] Valentina said, "Our attention is now turning to a second field trial that's in the diary for this year to further hone and improve the polymer so we can continue turning our research into reality. The beauty of a material like this is its lack of toxicity, the relative simplicity of its production and the fact that it can be scaled up easily—making it an incredibly attractive prospect for several other industries, not just agriculture."

Journal Reference:
Liam A. Crawford et al, A potential alternative to fungicides using actives-free (meth)acrylate polymers for protection of wheat crops from fungal attachment and infection, Green Chemistry (2023). DOI: 10.1039/D3GC01911J


Original Submission

posted by hubie on Thursday January 11 2024, @05:47PM   Printer-friendly
from the Radio-Radio-Elvis-Costello dept.

As reported in USA Today https://www.usatoday.com/story/money/business/2024/01/08/audacy-radio-bankruptcy/72147915007/ and many outlets:

Radio giant Audacy announced that it plans to file for Chapter 11 bankruptcy, on Sunday.

The company, which owns more than 200 stations across the U.S., announced in a news release it agreed to a prepackaged restructuring support agreement (RSA) with a supermajority of its debt-holders that will allow it to reduce its debt. The company says the plan would reduce its debt by 80% from around $1.9 billion to about $350 million.

Under this agreement, debtholders will receive equity in the reorganized company.

"Over the past few years, we have strategically transformed Audacy into a leading, scaled multi-platform audio content and entertainment company," said David Field, CEO of Audacy.

Do you listen to the radio? Your AC submitter still enjoys having music chosen by a pro -- but there are fewer and fewer high quality DJs around to fill that role...and probably even fewer job slots available in this era of corporate radio.

Best anthem to radio? https://www.youtube.com/watch?v=RAUUVYZ-z7A
or an intense (but partial) version from Saturday Night Live, https://www.youtube.com/watch?v=eD_24nDzkeo


Original Submission

posted by hubie on Thursday January 11 2024, @01:04PM   Printer-friendly

https://www.techdirt.com/2024/01/10/piracy-is-surging-again-because-streaming-execs-ignored-the-lessons-of-the-past/

Back in 2019 we noted how the streaming sector risked driving consumers back to piracy if they didn't heed the lessons of the past. We explored how the rush to raise rates, nickel-and-dime users, implement arbitrary restrictions, and force users toward hunting and pecking their way through a confusing platter of exclusives and availability windows risked driving befuddled users back to piracy.

And lo and behold, that's exactly what's happening.


Original Submission

posted by hubie on Thursday January 11 2024, @08:20AM   Printer-friendly
from the late-and-over-budget-as-usual dept.

NASA expected to announce 'months-long delay' for crewed Artemis moon mission:

NASA leadership is expected on Tuesday to announce a "months-long delay" to the first crewed mission of the agency's flagship Artemis program, according to one current and one former NASA employee.

The delay affects NASA's Artemis II mission, which aims to send four astronauts on a journey to fly by the moon and was slated to lift off this November.

But the mission is no longer expected to take place before 2025, according to the sources, confirming months of speculation that a delay was imminent.

NASA's Inspector General hinted at potential delays for the mission in a November report, citing three main challenges the space agency must address before it can safely fly humans to the moon.

First, the ground structure used to build, transport and launch the program's massive Space Launch System rocket — dubbed Mobile Launcher 1 — "sustained more damage than expected."

The November report stated that repairs to the structure were ongoing.

Second, the heat shield on the Orion spacecraft — intended to be the astronauts' home on Artemis II — "eroded in an unexpected way" during Artemis I as it was exposed to temperatures about half as hot as the surface of the sun upon reentry into Earth's atmosphere.

Finally, the Inspector General noted what NASA officials believed to be "the primary critical path" for the Artemis II mission: preparing Orion for its first crew and integrating it with the European Service Module, which provides power and propulsion. The "critical path" in project planning refers to the aspect of the mission that's expected to take the longest.


Original Submission

posted by hubie on Thursday January 11 2024, @03:35AM   Printer-friendly
from the fine-young-macrophages dept.

https://newatlas.com/medical/rac2-protein-macrophages-cannibalize-t-cells-cancer-immunotherapy/

Following a trail of evidence that started with a study of fruit flies nearly 25 years ago, researchers have found adding a hyperactive form of the protein Rac2 to macrophages, immune cells that eat pathogens, causes them to cannibalize T cells. The novel technique could potentially boost the effectiveness of an emerging cancer treatment.

Rac proteins have been around for a long time. Deeply conserved in evolution, the proteins are thought to have been present in the earliest nucleated cells. But, despite their age, scientists are still uncovering their mysteries. In a new study, researchers from the University of California Santa Barbara (UCSB) discovered more about how Rac proteins work and how they could potentially improve cancer treatment.

The human genome encodes three Rac proteins. Rac1 is expressed ubiquitously, Rac2 is expressed predominantly in cells that produce blood components (hematopoietic cells), and Rac3 is expressed primarily in brain tissue. Back in 1996, researchers studying fruit flies found that the proteins were instrumental in cell movement and that a hyperactive form of Rac1, expressed in only a few cells in a fly's egg chamber, destroyed the whole tissue.

"Just expressing this active Rac in six to eight cells kills the entire tissue, which is composed of about 900 cells," said Abhinava Mishra, the current study's lead author.

That was as far as the researchers got in the '90s. It wasn't until a few years ago that research started to emerge suggesting that cannibalism might be the cause of this tissue destruction.

In 2019, a study published in the journal Blood reported on three unrelated people with recurrent infections and a significant lack of T cells, specialized white blood cells crucial to the immune system, had the same mutation that hyperactivates Rac2. The study also observed that many of the patient's neutrophils, cells that capture and ingest invading microorganisms, were enlarged, indicating they were consuming a lot of cellular material.

After reading this study, Denise Montell, who was involved in the 1996 research and is the corresponding author in the current study, wondered whether the T cells' disappearance was due to innate immune cells with active Rac2 eating them, as had happened with the fruit flies. So, Montell and the other researchers turned their focus to macrophages, the voracious counterpart of the neutrophil. The researchers cultured human macrophages with and without hyperactive Rac2, together with T cells, and found that macrophages with hyperactive Rac consumed more cells, confirming their hypothesis.

Journal Reference:
Abhinava K. Mishra et al., Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing, PNAS, 2023. https://doi.org/10.1073/pnas.2310221120


Original Submission