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Phoenix666 [soylentnews.org] writes:

New research by Lawrence Livermore scientists shows how shock waves can damage membrane proteins in traumatic brain injury patients [phys.org].

Blast-induced traumatic brain injury (TBI) from improvised explosive devices is the most frequent wound occurring from the conflicts in Afghanistan and Iraq. Estimates suggest more than 200,000 veterans have had at least one traumatic brain injury.

Clinical reports and in vivo studies show exposure to a blast can cause TBI, although how the energy is transmitted to the brain is not well understood.

That's where Livermore researchers come in. Using molecular dynamics (MD) simulations, LLNL physicists Ed Lau and Eric Schwegler, along with University of North Carolina (link is external) colleague Max Berkowitz, found that ion channels are resistant to damage by shock waves. But with the presence of bubbles, the damage from shock waves is magnified and can contribute to an electrolyte imbalance within cells that can lead to the initial symptoms of TBI, such as headaches and seizures.

When a body is exposed to a blast, shock waves are produced, resulting in shear forces within the cranium. How cells react to shock waves is not well understood.

Cell walls are composed mainly of lipids but contain a large number of proteins that are vital for the normal function of the cell. The team performed all-atom MD simulations on shock-wave-induced bubble collapse to determine its impact on a nerve membrane-bound protein.

Presumably the findings have implications for football and boxing, too, in which concussions are common.

Original Submission