SoylentNews is people
SoylentNews
Submission Preview
Nucleus of cancer cells rupture during migration
When cancer cells migrate from the primary tumor they have to squeeze through densely packed cells of the tumor and surrounding microenvironment. New research shows that the physical stress of migrating through tight spaces can result in the rupture of the nuclear envelope and damage to the cell's genome.
While [nuclear envelope] rupture, and resulting genomic instability, may promote cancer progression, it may also represent a particular weakness of metastatic cancer cells and an opportunity to develop novel anti-metastatic drugs by specifically targeting these cells, for example, by blocking [nuclear envelope] repair and inhibiting DNA damage repair.
http://science.sciencemag.org/content/early/2016/03/25/science.aad7297 [sciencemag.org]
http://www.sciencemag.org/news/2016/03/cells-can-do-twist-sometimes-their-nuclei-burst?utm_source=sciencemagazine&utm_medium=twitter&utm_campaign=dothetwist-3196 [sciencemag.org]
