Spotted on HackerNews is a link to this discrete 6502 build [tubetime.us] by Eric Schlaepfer, which uses over four thousand transistors on a 12 × 15 inch four layer circuit board:
Well, a while back I had this idea about creating a discrete version of a microprocessor, but it just sounded too difficult, time consuming, or impractical. And part of me didn’t want to do it, because it just sounds so tedious to design–at every stage, I was secretly hoping to find a show-stopping problem. But part of me was really interested to see if it could be done.
The main project page [monster6502.com] has more technical detail, including a parts list, and the board will also be shown at the Maker Faire Bay Area 2016 [makerfaire.com], on May 20th - 22nd.
HN Discussion thread [ycombinator.com].