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Using Magnets to Control Chemical Reactions That Target Release of Medicines Inside the Body

Accepted submission by Phoenix666 at 2017-11-21 14:17:00
Science

The magnets can tightly target drug release [phys.org]:

A team of researchers with the University of Georgia in Athens has developed a technique for controlling chemical reactions that release drugs inside the body. In their paper published in the journal Nature Catalysis, the group describes coating chemicals to prevent a reaction from occurring until the application of a magnetic field that releases a desired drug.

In some medical applications, it is better for a medical treatment if a chemical can be applied directly to a certain part of the body and nowhere else. Chemicals meant to treat tumors are the prime example—chemotherapy drugs act on every cell they contact, causing a host of negative side effects. In this new effort, the group took a novel approach to solving this problem, using a magnet to force coated chemicals together, prompting a drug releasing reaction.

To provide a means for controlling when chemicals come into contact inside the body, the researchers created tiny packets by first coating iron oxide nanoparticles with silica and then coating them further with two types of polymers, which, when combined, form a brush-like structure. Each of the packets was then loaded with either an enzyme or a substrate meant to react with the enzyme, and, of course, the drug to be released.

The technique is intended to better target chemotherapy in cancer treatments such that only tumors are exposed to the chemical agents. It is hoped the more precise targeting can avoid the side effects of chemotherapy.


Original Submission