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A Vaccine Targeting Aged Cells Mitigates Metabolic Disorders in Obese Mice

Accepted submission by Phoenix666 at 2020-06-30 22:19:06
Science

ScienceDaily [sciencedaily.com]:

Aging is a multifaceted process that affects our bodies in many ways. In a new study, researchers from Osaka University developed a novel vaccine that removes aged immune cells and then demonstrated an improvement of diabetes-associated metabolic derangements by vaccinating obese mice.

Aged, or senescent, cells are known to harm their surrounding younger cells by creating an inflammatory environment. A specific type of immune cell, called T cell, can accumulate in fat tissues in obese individuals in senescence, causing chronic inflammation, metabolic disorders and heart disease. To reduce the negative effects of senescent cells on the body, senotherapy was developed to target and eliminate these rogue cells. However, as this approach does not discriminate between different types of senescent cells, it has remained unknown whether specific depletion of senescent T cells can improve their adverse effects on organ physiology.

Pachyderms beware.


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