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10.1038/s41586-021-03363-z
Vaccination against mutated protein tested in brain tumor patients for the first time [www.dkfz.de]:
Tumor vaccines can help the body fight cancer. Mutations in the tumor genome often lead to protein changes that are typical of cancer. A vaccine can alert the patients� immune system to these mutated proteins. For the first time, physicians and cancer researchers from Heidelberg and Mannheim have now carried out a clinical trial to test a mutation-specific vaccine against malignant brain tumors. The vaccine proved to be safe and triggered the desired immune response in the tumor tissue, as the team now reports in the journal Nature.
Journal Reference:
Michael Platten, Lukas Bunse, Antje Wick, et al. A vaccine targeting mutant IDH1 in newly diagnosed glioma [open], Nature (DOI: 10.1038/s41586-021-03363-z [doi.org])