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Pig heart transplant failure: Doctors detail everything that went wrong

Accepted submission by Freeman at 2022-06-28 17:24:34 from the working on the details dept.
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https://arstechnica.com/science/2022/06/pig-heart-transplant-failed-as-its-heart-muscle-cells-died/ [arstechnica.com]

Earlier this year, news broke of the first experimental xenotransplantation [arstechnica.com]: A human patient with heart disease received a heart from a pig that had been genetically engineered to avoid rejection. While initially successful, the experiment ended two months later [arstechnica.com] when the transplant failed, leading to the death of the patient. At the time, the team didn't disclose any details regarding what went wrong. But this week saw the publication of a research paper that goes through everything that happened to prepare for the transplant and the weeks following.

Critically, this includes the eventual failure of the transplant, which was triggered by the death of many of the muscle cells in the transplanted heart. But the reason for that death isn't clear, and the typical signs of rejection by the immune system weren't present. So, we're going to have to wait a while to understand what went wrong.

Previously:
Man Who Received a Heart Transplant From a Pig Has Died [soylentnews.org]


Original Submission