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mrpg [10.9.8.7] writes:

https://www.nature.com/articles/d41586-025-00554-w [nature.com]

A slimy barrier lining the brain’s blood vessels could hold the key to shielding the organ from the harmful effects of ageing, according to a study in mice.

The study showed that this oozy barrier deteriorates with time, potentially allowing harmful molecules into brain tissue and sparking inflammatory responses. Gene therapy to restore the barrier reduced inflammation in the brain and improved learning and memory in aged mice. The work was published today in Nature1.

The finding shines a spotlight on a cast of poorly understood molecules called mucins that coat the interior of blood vessels throughout the body and give mucus its slippery texture, says Carolyn Bertozzi, a Nobel-prizewinning chemist at Stanford University in California and a lead author of the study. “Mucins play a lot of interesting roles in the body,” she says. “But until recently, we didn’t have the tools to study them. They were invisible.”

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