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Cure for Pancreatic Cancer? Spanish Scientists’ Claim Ignites Global Hope and Debate [timesnownews.com]:

A Spanish research team has claimed to have developed a treatment that completely eliminates the most aggressive form of pancreatic cancer in laboratory mice, raising fresh hopes against one of the deadliest cancers. Pancreatic cancer is often diagnosed late and is completely resistant to most existing treatments in later stages.

So, when Dr Mariano Barbacid claimed to have discovered a potential “cure,” it sent ripples of hope across the global medical community and sparked intense scientific debate. The claim, made by the Spanish National Cancer Research Centre, working on an experimental therapy targeting the tumour cells, suggests that their approach could stop cancer growth and, in some cases, completely eliminate malignant cells in laboratory and early animal studies.

The CNIO therapy is an amalgamation of three drugs that are designed to shut down multiple tumour survival mechanisms simultaneously. According to the researchers, this strategy prevents cancer cells from rewiring themselves, a common cause of treatment failure. Dr Barbacid has previously argued that pancreatic cancer cannot be defeated with a single-drug strategy.

Given pancreatic cancer’s grim statistics - five-year survival rates hovering around 10 per cent - the announcement has quickly drawn global attention.

Dr Mariano Barbacid and his team claims to have developed a treatment for pancreatic cancer that completely eliminates it

Why is pancreatic cancer extremely hard to treat?

Pancreatic cancer is super aggressive. Symptoms like abdominal pain, weight loss, or jaundice often appear only after the disease has advanced well beyond the pancreas. By then, the only curative option remains surgery, which may no longer be possible for most patients.

Also, pancreatic tumours are mostly surrounded by a dense, fibrous tissue called stroma that acts like a shield. This barrier prevents chemotherapy drugs and immune cells from effectively reaching cancer cells, making many treatments far less effective than in other cancers.

Pancreatic cancer is super aggressive with no clear initial warning signs

What is Dr Barbacid claiming in his discovery?

Preliminary reports say Dr Barbacid and his research team have developed a therapy that is able to disrupt the protective tumour environment, along with triggering cancer cells' death. The approach reportedly combines molecular targeting with immune system activation, which makes the tumours extremely vulnerable to treatment.

In the laboratory, according to the researchers, the therapy has been able to stop tumour progression and, in some models, even eradicate cancer cells entirely. These findings are yet to be validated in humans and could represent a major breakthrough.

However, the work is still in early stages, as many of the results so far come from preclinical studies, not large-scale human trials.

Also read: Why 7 in 10 Cancer Cases Go Undetected Until It’s Too Late [timesnownews.com]

Caution urged

Even though the news has spread viral, cancer researchers are urging restraint, as there have been many promising cancer breakthroughs in the past which showed remarkable results in the lab but could not bring in any real-world benefits for patients in the real world.

Scientists feel that what works in animal models may not necessarily always work in humans. Also, reproducibility is another concern, as independent verification by other research groups, peer-reviewed publication, and rigorous clinical trials are essential before any treatment can be considered a true cure.

The next step, according to the scientists, is the human clinical trials, which will ultimately determine if the therapy is safe, effective, and superior to existing treatments.

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See also:

• Just a moment... [pnas.org]

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