SoylentNews

Phoenix666 [soylentnews.org] writes:

Optogenetics is a marvel of our age, enabling neuroscientists to turn brain cells on and off with pulses of light. But until now there’s been an obvious difficulty: How do you deliver that light to brain cells that are tucked inside an animal’s skull?

Today we get the best answer yet [ieee.org], from the Stanford lab of Ada Poon. She and her colleagues have invented a tiny, wireless LED device that can be fully implanted beneath the skin of a mouse. The device lets researchers turn on the light and stimulate neurons when the mouse is scampering around, behaving more or less normally. This system, described today in the journal Nature Methods, seems a big improvement over previous technology, which used wires or bulky head-mounted devices to activate the light switch.

Here’s a quick optogenetics primer, in case you need it. The technique makes use of neurons that have been genetically altered to respond to light, often with the introduction of genes from a strain of green algae. Researchers can control which part of a mouse brain contains these light-sensitive neurons, and they can then study the function of that brain region by activating the neurons—essentially turning them on and off—while watching the animal’s behavior. Using this method, scientists can learn about basic brain anatomy or study dysfunctions seen in human diseases.

Original Submission