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An Anonymous Coward writes:

It's long been known that exercise can lead to denser, stronger bones. On the Proceedings of the National Academy of Sciences [pnas.org] website, researchers report that when they injected mice with the peptide irisin, which is produced by muscles during exercise, the bones of the treated mice became stronger (as compared to controls). Irisin has the same amino acid sequence in mice as in humans.

http://news.sciencemag.org/biology/2015/09/muscle-protein-may-beef-bones-after-exercise [sciencemag.org]

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