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posted by martyb on Monday December 31 2018, @02:13PM   Printer-friendly
from the we-have-the-balls-to-print-stories-that-matter! dept.

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism:

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8.

Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.

tl;dr: ibuprofen can reduce testosterone production and interfere with fertility.


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  • (Score: 4, Insightful) by RandomFactor on Monday December 31 2018, @02:24PM (19 children)

    by RandomFactor (3682) Subscriber Badge on Monday December 31 2018, @02:24PM (#780257) Journal

    Aspirin, which would never get past the FDA if released today.

    --
    В «Правде» нет известий, в «Известиях» нет правды
    • (Score: 5, Funny) by The Mighty Buzzard on Monday December 31 2018, @02:29PM (14 children)

      by The Mighty Buzzard (18) Subscriber Badge <themightybuzzard@proton.me> on Monday December 31 2018, @02:29PM (#780259) Homepage Journal

      Yup, they'd probably illegalize willow trees too just to be sure.

      --
      My rights don't end where your fear begins.
      • (Score: 3, Funny) by JoeMerchant on Monday December 31 2018, @02:36PM (12 children)

        by JoeMerchant (3937) on Monday December 31 2018, @02:36PM (#780261)

        That's coming from the NSAID manufacturer's association: "Willow trees are worthless weeds that sap the productive energy from people who see them. They cause obesity, clog your arteries, rot your teeth, and exposure to their sap can cause uncontrolled bleeding." If it weren't so damn expensive to eradicate them all, the NSAID manufacturers' lobbyists would have made a play for them years ago.

        --
        🌻🌻🌻 [google.com]
        • (Score: 1) by khallow on Monday December 31 2018, @03:07PM (6 children)

          by khallow (3766) Subscriber Badge on Monday December 31 2018, @03:07PM (#780268) Journal
          Aspirin is just another NSAID to profit from. It didn't start in the public domain after all.
          • (Score: 4, Insightful) by JoeMerchant on Monday December 31 2018, @03:53PM (5 children)

            by JoeMerchant (3937) on Monday December 31 2018, @03:53PM (#780279)

            Now that Aspirin is public domain, it's time to villify it, like they did saccharine when new alternatives came out, margarine, etc.

            --
            🌻🌻🌻 [google.com]
            • (Score: 1) by khallow on Monday December 31 2018, @06:32PM

              by khallow (3766) Subscriber Badge on Monday December 31 2018, @06:32PM (#780339) Journal
              "Now that Aspirin is public domain". As I already noted, it didn't start in the public domain. RandomFactor's point is that drug regulation has degenerated greatly since Aspirin was first put on the market. This is a separate issue from business marketing strategies.
            • (Score: 3, Interesting) by Runaway1956 on Monday December 31 2018, @09:51PM (2 children)

              by Runaway1956 (2926) Subscriber Badge on Monday December 31 2018, @09:51PM (#780396) Journal

              They haven't spent enough time, money, or effort villifying saccharine. Or margarine. Both are polished turds.

              --
              “I have become friends with many school shooters” - Tampon Tim Walz
              • (Score: 3, Interesting) by JoeMerchant on Tuesday January 01 2019, @12:42AM (1 child)

                by JoeMerchant (3937) on Tuesday January 01 2019, @12:42AM (#780455)

                Saccharine isn't nearly the polished turd that NutraSweet aka Aspartame is, by comparison saccharine is a well rolled beetle dung ball while Aspartame is a steaming predator patty full of formaldehyde precursors.

                --
                🌻🌻🌻 [google.com]
                • (Score: 0) by Anonymous Coward on Wednesday January 02 2019, @02:44AM

                  by Anonymous Coward on Wednesday January 02 2019, @02:44AM (#780848)

                  Oh come now
                  Name something better for killing ants

            • (Score: 2) by dry on Wednesday January 02 2019, @03:55AM

              by dry (223) on Wednesday January 02 2019, @03:55AM (#780875) Journal

              Still trademarked here in Canada and Mexico amongst other countries. Should have demanded that the US re-trademark it as a condition of the CUSMA (NAFTA2) as it was mostly about IP anyways.

        • (Score: 0) by Anonymous Coward on Monday December 31 2018, @07:10PM (4 children)

          by Anonymous Coward on Monday December 31 2018, @07:10PM (#780357)

          I have one of these fuckers in my yard, they are fucking useless. Just grow roots everywhere and wreck cobblestones.

          • (Score: 2) by Phoenix666 on Tuesday January 01 2019, @01:30AM

            by Phoenix666 (552) on Tuesday January 01 2019, @01:30AM (#780476) Journal

            Willow trees are great resources if you know how to use them. Aspirin has been mentioned, but the withies are quite useful for making furniture, baskets, thatching, and that sort of thing. You can make fishing poles and other things, too. If you garden you can use them to create raised beds. They make excellent shade trees to sit under in the summer and have a cool glass of iced tea.

            --
            Washington DC delenda est.
          • (Score: 2, Funny) by Ethanol-fueled on Tuesday January 01 2019, @04:13AM (2 children)

            by Ethanol-fueled (2792) on Tuesday January 01 2019, @04:13AM (#780532) Homepage

            Then fucking stump it and then chain the stump to the back of your Cummins Turbo Diesel and rip it out. Every day you don't, that Willow tree is just laughing at you and thinks you're a pussy. He's telling all his tree friends that you're a pussy, and when your bitch sits under him he tells her the same thing after she rubs his branches off. Open your curtains and look at him. So you see him pointing at you and laughing, and hear his mocking cries in your sleep?

            • (Score: 2, Informative) by Sulla on Tuesday January 01 2019, @04:54AM

              by Sulla (5173) on Tuesday January 01 2019, @04:54AM (#780542) Journal

              >achieving any sort of thing with a dodge

              Thanks for the laugh +1 funny

              --
              Ceterum censeo Sinae esse delendam
            • (Score: 2) by JoeMerchant on Wednesday January 02 2019, @01:11AM

              by JoeMerchant (3937) on Wednesday January 02 2019, @01:11AM (#780811)

              For Brazilian pepper, I cut it down 3 times in 2 years, finally got it by pouring 2 cycle engine fuel into the raw / drilled to a cup stump.

              --
              🌻🌻🌻 [google.com]
      • (Score: 2) by dry on Wednesday January 02 2019, @03:58AM

        by dry (223) on Wednesday January 02 2019, @03:58AM (#780878) Journal

        Then we'd just use Spirea, it's even in the name.

    • (Score: 2) by hendrikboom on Tuesday January 01 2019, @02:23AM (2 children)

      by hendrikboom (1125) on Tuesday January 01 2019, @02:23AM (#780491) Homepage Journal

      Aspirin could pass the FDA as a prescription drug -- to combat excessive blood clots.

      For pain, it is a dangerous drug, especially for children. It seems to be a cause for some kind of syndrome hose name I forget.

      As an over-the-counter analgesic -- wouldn't you prefer your blood to remain inside you? It increases the chance of uncontrolled bleeding in a subpopulation. Do you know if you're part of that subpopulation? Have you got enough risk factors yet? Need more?

      -- hendrik

      • (Score: 1) by khallow on Tuesday January 01 2019, @03:20AM

        by khallow (3766) Subscriber Badge on Tuesday January 01 2019, @03:20AM (#780513) Journal
        I know everyone has enough risk factors for death.
      • (Score: 2) by RandomFactor on Tuesday January 01 2019, @07:20AM

        by RandomFactor (3682) Subscriber Badge on Tuesday January 01 2019, @07:20AM (#780569) Journal

        Here's some reading: http://www.cnn.com/2010/HEALTH/12/22/aspirin.history/index.html [cnn.com]

        Aspirin's been around and a medical staple since the late 1800's. It's not perfect, but if used properly it generally lives up to it's designation as a wonder drug.

        (CNN) -- If you take aspirin, you've got a pain reliever, heart attack preventer and possible cancer preventer rolled into one tablet.

        and that's ignoring using it as a blood thinner/anti-coagulant which seems to be a forgotten capability.

        "If I'm stranded on a desert island, and I can take one drug with me, that's the one I'm taking," Watson said.

        --
        В «Правде» нет известий, в «Известиях» нет правды
    • (Score: 1, Interesting) by Anonymous Coward on Tuesday January 01 2019, @04:43AM

      by Anonymous Coward on Tuesday January 01 2019, @04:43AM (#780540)

      Someone didn't read the article. Shocking, I know.
      They tested ibuprofen but aspirin and Tylenol are thought to work similarly. I wouldn't bet on aspirin being a safe alternative for the anti-testosterone problem.

  • (Score: 1, Interesting) by Anonymous Coward on Monday December 31 2018, @03:06PM (14 children)

    by Anonymous Coward on Monday December 31 2018, @03:06PM (#780267)

    Always figured there was some merit in just shrugging off pain, in addition to the macho "cred" that comes from peers when gutting-out childhood injuries. So, I've used painkillers very infrequently.

    On the other hand, not getting proper treatment after an injury was a false economy. As a kid, crashing a dirt bike (motorcycle) numerous times I would have done well to visit a physical therapist or other "body work" expert...at the time. Might have reduced the level of back pain that I have now.

    • (Score: 3, Interesting) by RS3 on Monday December 31 2018, @03:44PM (4 children)

      by RS3 (6367) on Monday December 31 2018, @03:44PM (#780276)

      Possibly. Inflammation reduction usually lessens localized tissue damage, so in the short-term NSAIDs can be good.

      Another downside of pain killers in general is they can mask a problem, delaying corrective treatment.

      Also, they could embolden risk-takers. Of course alcohol does that very well.

      • (Score: -1, Troll) by Anonymous Coward on Monday December 31 2018, @04:20PM (1 child)

        by Anonymous Coward on Monday December 31 2018, @04:20PM (#780293)

        "Also, they could embolden risk-takers."

        -

        What's the matter, faggot ?

        You don't like people who have more courage than you do ?

        Hang yourself.

        • (Score: 3, Funny) by fritsd on Monday December 31 2018, @05:01PM

          by fritsd (4586) on Monday December 31 2018, @05:01PM (#780306) Journal

          What's the matter, faggot ?

          You don't like people who have more courage than you do ?

          Hang yourself.

          Happy new year to you too! May you be as bold and intrepid as May! :-/

          https://www.caglecartoons.com/viewimage.asp?ID={3EBF4BA2-6B8F-4AB4-981E-8A7B8E9C5892} [caglecartoons.com]
          (cartoon by Jos Collignon, originally in de Volkskrant)

          One of Theresa May's ministers said: "we've had enough of experts", and many of them have tried to explain that actual brexit risk evaluations were top secret, or lost somewhere in the basement behind the door that says "beware of the leopard".
          So it's probably best to press on with it, to see what will happen to the UK in 3 months.

      • (Score: 2) by DannyB on Monday December 31 2018, @04:57PM

        by DannyB (5839) Subscriber Badge on Monday December 31 2018, @04:57PM (#780304) Journal

        grandparent: > shrug off pain

        I agree.

        parent: > in the short-term NSAIDs can be good.

        Yep. Long term severe arthritis problems can be helped by long term use of NSAIDs. But that comes with problems too. There are lots of prescription NSAIDs. Your doctor can work with you to find a potent one that you can take several times per day without side effects . . . for you! Every drug has side effects for someone. Only the very safest ones ever get to be over the counter.

        > downside of pain killers in general

        Even with potent NSAIDs, you can still be in pain. Just about anyone with arthritis will tell you there are good days and bad days. When the pain gets to be too much, there are good prescription opiate drugs. But if those are for anything other than occasional use, the end of that story will not be a good one.

        That brings me back to: shrug off the pain, and NSAIDs are helpful, and long term use may, in some cases, be more beneficial, on balance, than the long term detriment of taking those NSAIDs. But that is something done under a doctor's supervision, for decades or more.

        --
        Why is it so difficult to break a heroine addiction?
      • (Score: 2) by RandomFactor on Monday December 31 2018, @05:55PM

        by RandomFactor (3682) Subscriber Badge on Monday December 31 2018, @05:55PM (#780321) Journal

        There was evidence out some decades back that they reduced muscle growth associated with exercise some also.

        --
        В «Правде» нет известий, в «Известиях» нет правды
    • (Score: 2) by The Mighty Buzzard on Monday December 31 2018, @05:14PM (2 children)

      by The Mighty Buzzard (18) Subscriber Badge <themightybuzzard@proton.me> on Monday December 31 2018, @05:14PM (#780309) Homepage Journal

      Painkillers are fine for situations like when you have a pulled muscle and the pain is causing it to cramp and heal slower. Other than that, you should use as little of them as you can manage. None of them at effective pain killing doses are especially good for you.

      --
      My rights don't end where your fear begins.
      • (Score: 2, Informative) by Anonymous Coward on Monday December 31 2018, @06:48PM (1 child)

        by Anonymous Coward on Monday December 31 2018, @06:48PM (#780348)

        A major benefit of NSAID is relieving inflammation, an immune response that actually hinders healing of muscle/bone tissue injury.

    • (Score: 1, Funny) by Anonymous Coward on Monday December 31 2018, @06:45PM (4 children)

      by Anonymous Coward on Monday December 31 2018, @06:45PM (#780346)

      As a kid, crashing a dirt bike (motorcycle) numerous times I would have done well to visit a physical therapist or other "body work" expert...at the time. Might have reduced the level of back pain that I have now.

      How about wearing proper safety gear, not taking undue risks and not riding faster than you can think?

      • (Score: 0) by Anonymous Coward on Monday December 31 2018, @09:54PM (2 children)

        by Anonymous Coward on Monday December 31 2018, @09:54PM (#780397)

        Can't you read?

        Opening line of parent is, "As a kid..."

        • (Score: 0) by Anonymous Coward on Tuesday January 01 2019, @01:05AM (1 child)

          by Anonymous Coward on Tuesday January 01 2019, @01:05AM (#780462)

          When you were a kid and riding motorcycles - you couldn't think?

          • (Score: 1) by khallow on Tuesday January 01 2019, @03:22AM

            by khallow (3766) Subscriber Badge on Tuesday January 01 2019, @03:22AM (#780515) Journal
            That's a pretty common problem. Kid brains are notoriously unreliable in the ole risk assessment department.
      • (Score: 2) by The Mighty Buzzard on Tuesday January 01 2019, @03:57AM

        by The Mighty Buzzard (18) Subscriber Badge <themightybuzzard@proton.me> on Tuesday January 01 2019, @03:57AM (#780526) Homepage Journal

        How about wearing proper safety gear, not taking undue risks and not riding faster than you can think?

        That pretty much negates everything that makes riding a dirtbike fun. Pansy.

        --
        My rights don't end where your fear begins.
    • (Score: 0) by Anonymous Coward on Tuesday January 01 2019, @08:07AM

      by Anonymous Coward on Tuesday January 01 2019, @08:07AM (#780575)

      I think I have a better pain threshold than most males (ones I've befriended anyway) albeit I'm a fucking baby with man cold. I'm virile with hair in everywhere but on my palms and the bottoms of my feet!

  • (Score: 2) by Subsentient on Monday December 31 2018, @03:38PM (7 children)

    by Subsentient (1111) on Monday December 31 2018, @03:38PM (#780275) Homepage Journal

    So it reduces the chances of me knocking some girl up. Hey, works for me. I don't want kids, ever. I've already got a square Schwarzaneggar jaw and every inch is covered in hair, so I doubt it'll affect my "masculinity" in any measurable way.

    --
    "It is no measure of health to be well adjusted to a profoundly sick society." -Jiddu Krishnamurti
    • (Score: 0) by Anonymous Coward on Monday December 31 2018, @04:12PM (5 children)

      by Anonymous Coward on Monday December 31 2018, @04:12PM (#780287)

      The risk is less to do with knocking up someone but more to do with birth defects. Say, some types of autism...

      Appearence wise, that has more to do with the proliferation (or lack of) receptor sites of varying types and cells unless we're talking about exogenous hormones. Like, some women have more muscle mass than the average men despite having a 1/5th of the testosterone the average men does... Others, especially northern Europeans and Russians, have the kind of thick cubic jaw that would Arny feel girly... But then again, Arny is a bad example since he had such poor natural test levels that he started taking shots as early as 14yr/olds. And from I know, never really stopped.

      • (Score: 2) by fritsd on Monday December 31 2018, @05:06PM (4 children)

        by fritsd (4586) on Monday December 31 2018, @05:06PM (#780308) Journal

        I once met a girl with a jaw like a clothes iron. Pretty, too, I mean it suited her. A mathematics student. Not from Northern Europe but from the Netherlands. True story.

        • (Score: 2) by PiMuNu on Monday December 31 2018, @06:49PM (3 children)

          by PiMuNu (3823) on Monday December 31 2018, @06:49PM (#780349)

          Since when are the Netherlands not in Northern Europe?

          • (Score: 1) by fritsd on Monday December 31 2018, @07:02PM

            by fritsd (4586) on Monday December 31 2018, @07:02PM (#780355) Journal

            More like West Europe, innit?

          • (Score: 0) by Anonymous Coward on Monday December 31 2018, @09:33PM (1 child)

            by Anonymous Coward on Monday December 31 2018, @09:33PM (#780390)

            "Northern Europe" usually means the Nordic plus Baltic states. From the truth [wikipedia.org]:

            Northern Europe is the general term for the geographical region in Europe that is approximately north of the southern coast of the Baltic Sea [..] Countries which are central-western (such as Belgium), central (such as Austria) or central-eastern (such as Poland) are not usually considered part of either Northern or Southern Europe

            From that description, The Netherlands would also be considered central-western, thus part of neither Northern nor Southern Europe.

            I also stumbled upon the term Baltoscandia [wikipedia.org]. Fun stuff.

            • (Score: 2) by PiMuNu on Tuesday January 01 2019, @09:44AM

              by PiMuNu (3823) on Tuesday January 01 2019, @09:44AM (#780587)

              Ah, I am used to this definition:

              "Historically, when Europe was dominated by the Roman Empire, everything not near the Mediterranean region was termed Northern Europe, including southern Germany, all of the Low Countries, and Austria. This meaning is still used today in some contexts, for example, discussions of the Northern Renaissance. "

              My bad.

    • (Score: 0) by Anonymous Coward on Tuesday January 01 2019, @12:36AM

      by Anonymous Coward on Tuesday January 01 2019, @12:36AM (#780452)

      You do know there is a procedure available that can remove the possibility of fathering children, right? And it many cases it can be reversed later if you change your mind (and have a good doctor on both ends). If you are so worried about making kids, that vasectomy should be looking real good to you... Just saying...

  • (Score: 3, Funny) by fyngyrz on Monday December 31 2018, @05:29PM (2 children)

    by fyngyrz (6567) on Monday December 31 2018, @05:29PM (#780315) Journal

    ibuprofen can reduce testosterone production and interfere with fertility.

    That could be a real headache.

    --
    Cats know how we feel. They just don't care.

    • (Score: 0) by Anonymous Coward on Monday December 31 2018, @08:06PM

      by Anonymous Coward on Monday December 31 2018, @08:06PM (#780371)

      ibuprofen can reduce testosterone production and interfere with fertility.

      That could be a real headache.

      ...or more of the times, an imaginary one.

    • (Score: 0) by Anonymous Coward on Monday December 31 2018, @08:13PM

      by Anonymous Coward on Monday December 31 2018, @08:13PM (#780374)

      Well, at least you won't have kids running around screaming to further enhance your headache

  • (Score: 1) by doke on Monday December 31 2018, @06:44PM (1 child)

    by doke (6955) on Monday December 31 2018, @06:44PM (#780345)

    Male pattern baldness is linked with a form of testosterone. Could ibuprofen possibly slow balding?

  • (Score: 1, Insightful) by Anonymous Coward on Monday December 31 2018, @07:37PM

    by Anonymous Coward on Monday December 31 2018, @07:37PM (#780359)

    tl;dr: One study has suggested that ibuprofen may reduce testosterone production and may therefore interfere with fertility.

    ftfy. People without any knowledge of science really shouldn't read science journals and try to tl;dr them for others.

  • (Score: -1, Troll) by Anonymous Coward on Monday December 31 2018, @08:20PM

    by Anonymous Coward on Monday December 31 2018, @08:20PM (#780377)

    So quickly distribute pills to everybody, especially in the developed countries! Perhaps the planet could still survive.

  • (Score: 0, Troll) by Anonymous Coward on Monday December 31 2018, @10:25PM

    by Anonymous Coward on Monday December 31 2018, @10:25PM (#780406)

    Ibuprofen, trigger warnings, safe spaces... all causes/results of insufficient testosterone.

  • (Score: 2) by Phoenix666 on Tuesday January 01 2019, @01:32AM (1 child)

    by Phoenix666 (552) on Tuesday January 01 2019, @01:32AM (#780477) Journal

    Sigh. Back to morphine, I guess.

    --
    Washington DC delenda est.
    • (Score: 2, Interesting) by Sulla on Tuesday January 01 2019, @04:58AM

      by Sulla (5173) on Tuesday January 01 2019, @04:58AM (#780543) Journal

      I have been using Tumeric recently as a cure-all. Dropped my blood pressure by 20 points drinking the tea each day with ginger and honey.

      --
      Ceterum censeo Sinae esse delendam
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