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Idiosyncratic use of punctuation - which of these annoys you the most?

  • Declarations and assignments that end with }; (C, C++, Javascript, etc.)
  • (Parenthesis (pile-ups (at (the (end (of (Lisp (code))))))))
  • Syntactically-significant whitespace (Python, Ruby, Haskell...)
  • Perl sigils: @array, $array[index], %hash, $hash{key}
  • Unnecessary sigils, like $variable in PHP
  • macro!() in Rust
  • Do you have any idea how much I spent on this Space Cadet keyboard, you insensitive clod?!
  • Something even worse...

[ Results | Polls ]
Comments:64 | Votes:118

posted by hubie on Wednesday July 05 2023, @09:28PM   Printer-friendly
from the THERE-is-my-flying-car dept.

First flying car approved by FAA, now available for preorder:

Under experimental status, the first flying car has officially been cleared for take off.

This week, Alef Aeronautics revealed its flying car "Model A" was granted legal permission from the Federal Aviation Administration to test run the vehicle on the road and in the sky − a move needed before it can be released to the public.

Alef is the first company to receive a Special Airworthiness Certification from the FAA, the company said in a news release. The certification limits the locations and purpose for which the vehicle is allowed to fly.

The vehicle will also need to meet National Highway and Traffic Safety Administration safety standards before taking flight.

But the company's CEO Jim Dukhovny says the company is "hopeful" the certification "will be our next step."

[...] The flying car is now available for preorder, the Santa Clara, California-based company posted on its website. Carrying one or two occupants, the vehicle will sell for about $300,000.

The "Model A" is 100% electric, drivable on public roads and has vertical takeoff and landing capabilities, the company wrote in its release.

The car will be a Low Speed Vehicle, meaning it won't go faster than about 25 miles per hour on a paved surface. If a driver needs a faster route, they will be able to use the vehicle's flight capabilities, according to Alef.

As of Friday, presales were open, with interested customers able to pay a $150 deposit to get on the waiting list, or $1,500 for a priority spot on the list's queue.

[...] Buyers will be able to complete their configuration as production nears, the company, backed by a Tesla investor, said.

The company said it plans to start delivering the vehicles to customers by late 2025.


Original Submission

posted by janrinok on Wednesday July 05 2023, @04:41PM   Printer-friendly

On paper, OLED displays can last for 100 years - if it wasn't for one color:

If humans could not see blue colors, then one of the biggest problems of OLED technology would have been quickly solved, namely the short shelf life of blue OLE diodes. If the need for the blue diodes did not exist, OLED panels could last over 100 years, or about a million hours.

That's what University of Michigan professors Stephen R. Forrest and Chris Giebink said at the recent Display Week in Los Angeles during a four-hour short course designed to look at the current state of OLED technology. But since OLED technology is only a little over 35 years old, these numbers are based on aging tests.

That green OLEDs in particular don't have a problem with durability can definitely be judged in practice by now. When Sony installed green OLED displays in its Walkman almost 20 years ago, few would have thought that they would still work. However, the author of these lines owns such an Atrac Walkman himself, whose display still shines in excellent quality.

However, only green (or red) displays would only be suitable for special applications. This includes, for example, the digital signage sector For a real display, it is not possible without the color blue and the problems have not been completely solved even 35 years after the emergence of the technology, although they have been greatly reduced.

The durability of a panel is increased by various tricks. Important for the blue pixels: They have to stay cool. To achieve this, the surface area is increased and the brightness is reduced in relation to the surface area. In turn, green OLEDs, for example, can be very small and shine extremely brightly. As Forrest said, the green OLEDs in an iPhone shine at around 10,000 candela per square meter.

So it's the mix that matters (at the moment). To put that in perspective, even the brightest iPhone Pro only manages 1,600 in HDR mode (2,000 outdoors), and that's only in a small space for peak light. Bright light (and thus high temperatures in the panel) reduces the battery life enormously.


Original Submission

posted by janrinok on Wednesday July 05 2023, @11:54AM   Printer-friendly
from the don't-ask-don't-tell dept.

Cash or card? Consumers pay strategically to forget guilty purchases, study shows:

"Will you be paying with cash or card?"

It's a question that's been asked of consumers for decades. And despite the increasing popularity of digital payment methods, cash and card remain the most popular choices worldwide. In 2021, 65 percent of all point-of-sale transactions globally were made using cash or card, according to Fidelity National Information Services.

Past research shows that 90 percent of households use multiple payment methods, but new research from the University of Notre Dame takes a first look into how consumers choose between them. The study finds that the justifiability of a purchase affects how consumers choose to pay.

[...] "When a purchase is difficult to justify — like buying an overpriced bottle of water at the airport, cigarettes or candy — consumers pay with less-trackable methods, like cash, so they can eliminate the paper or electronic trail and 'forget' this guilty purchase," said Bechler, who specializes in consumer behavior and social psychology with an emphasis on attitudes, persuasion and financial decision-making. "When a purchase is easy to justify, consumers have no problem paying with trackable methods like credit cards that create paper or electronic trails."

Despite the vast amount of research on financial decision-making in behavioral economics, consumer behavior and social psychology, this is the first study to take an in-depth look at how consumers choose to pay.

[...] "I think a lot of consumers — particularly those who diligently track their card expenses — recognize that they use cash so they don't have to think about certain purchases again," Bechler said. "In fact, this strategy of using cash to hide purchases from ourselves if we feel bad about them is something my co-authors and I admitted to doing ourselves."

The findings show merchants it's a good idea to be strategic with the types of payment methods they allow.

"A doughnut shop could benefit from letting its customers pay with cash because they may want to forget their unhealthy purchase," Bechler said. "A salad shop might not see the same benefit."

Journal Reference:
Christopher J. BechlerSzu-chi HuangJoshua I. Morris, Purchase Justifiability Drives Payment Choice: Consumers Pay with Card to Remember and Cash to Forget, Journal of the Association for Consumer Research, July2023 Vol. 8 Issue 4 DOI: https://doi.org/10.1086/726429 [PDF version]


Original Submission

posted by janrinok on Wednesday July 05 2023, @07:10AM   Printer-friendly

ECMAScript 2023 spec for JavaScript finalized:

ECMAScript 2023, an update to the official specification for the JavaScript programming language, has been approved by ECMA International. The new spec adds new methods for searching and changing arrays, extends the WeakMap API to allow unique symbols, and introduces some standardization for the use of hashbangs.

Approved on June 27, the ECMAScript 2023 specification cites the following synopsis of improvements:

ECMAScript 2023, the 14th edition, introduced the toSorted, toReversed, with, findLast, and findLastIndex methods on Array.prototype and TypedArray.prototype, as well as the toSpliced method on Array.prototype; added support for #! comments at the beginning of files to better facilitate executable ECMAScript files; and allowed the use of most Symbols as keys in weak collections.

The finished proposals, published by the ECMA TC39 (Technical Committee 39) on GitHub, elaborate on the four features to be published this year:

  • Array find from last, a proposal for .findlast() and .findLastIndex() methods on array and typed array. Finding an element in an array is a very common programming pattern, the proposal states. Scenarios under which this feature would be used include when a developer knows that finding an element from last to first may have better performance, or developers care about the order of the elements.
  • Permitting symbols as keys in WeakMap keys, a proposal that extends the WeakMap API to allow the use of unique symbols as keys. Currently, WeakMaps are limited to allow only objects as keys.
  • Change array by copy, a proposal that provides additional methods on Array.prototype and TypedArray.prototype to enable changes on the array by returning a new copy of it with the change.
  • Hashbang grammar, a proposal to match the de facto usage in some CLI JS hosts that allow for Shebangs/Hashbang. These hosts strip the hashbang to generate valid JS source texts before passing to JS engines. This plan would move the stripping to engines and unify and standardize how that is done.

Updated versions of ECMAScript traditionally are finalized by ECMA in June. Last year's ECMAScript 2022 featured class elements and top-level await capabilities.


Original Submission

posted by NCommander on Wednesday July 05 2023, @02:23AM   Printer-friendly
from the ssl-negotations-are-complex dept.

So, I know its been a bit quiet here, but we're working through getting through the last few items relating to cutting over to newer infrastructure. As such, its been working through the bug list, and there's one issue I want to get some feedback on.

Back in November when the infrastructure was upgraded to Ubuntu 22.04, a few users with older devices stopped being able to connect to SoylentNews. This confused me, since we've been using the same NGINX SSL termination setup that has been in use since at least 2016. Well, I finally found the root cause, and as it turns out, Canonical bumped up the minimum OpenSSL security level, which disabled several ciphers, and broke devices not supporting TLS 1.2 or later.

By testing the site with the SSL Labs site checker, it appears anything older than Android 4.0, or iOS 5 is broken. This mostly seems to be devices that are over a decade old at this point, and won't be able to browse the vast majority of sites on the Internet as is. We discussed this internally a bit, and I'm of the opinion that its not worth re-enabling the older ciphers to allow these devices to reconnect, especially since we're working to modernize the stack, and get it as up to date as we can get it. I also believe we had very few users who were actually affected by this, however, as the editors did get a few emails about SN breaking after the site upgrade, I wanted to poll the community, and make sure this is not a more widespread issue than initially believed.

Ultimately, this is going to be part of a broader discussion on what we will and won't support on SoylentNews going forward, and this seems as good of place as any to get the ball rolling.

~ NCommander

posted by Fnord666 on Tuesday July 04 2023, @09:37PM   Printer-friendly
from the seeing-is-believing dept.

Online art viewing is an untapped source of support for well-being:

Art can have a positive effect on our mood. But does this also work when we look at paintings on a screen? An international research team involving the University of Vienna, the Max Planck Institute for Psycholinguistics in Nijmegen and the Max Planck Institute for Empirical Aesthetics (MPIEA) in Frankfurt am Main decided to investigate this question. The study was funded by the EU Horizon ART*IS Project. The results have now been published as an open access article in the journal Computers in Human Behavior.

240 study participants viewed an interactive Monet Water Lily art exhibition from Google Arts and Culture. By filling out a questionnaire, they provided information about their state of mind, how much pleasure they felt when looking at the pictures, and how meaningful they considered the experience to be. The results showed significant improvements in mood and anxiety after just a few minutes of viewing.

The study also found that some participants were more receptive to art than others and were able to benefit more. This advantage could be predicted using a metric called "aesthetic responsiveness."

Journal Reference:
Trupp et al., Who benefits from online art viewing, and how: The role of pleasure, meaningfulness, and trait aesthetic responsiveness in computer-based art interventions for well-being [open], Computers in Human Behavior, 145, 2023. DOI: https://doi.org/10.1016/j.chb.2023.107764


Original Submission

posted by janrinok on Tuesday July 04 2023, @04:51PM   Printer-friendly
from the three-strikes-and-you're-out dept.

YouTube Threatens to Cut Off Ad Blocker Users After Just Three Ad-less Vids:

Google is testing how it can stop users from watching ad-free videos as ad revenue declines.

As first spotted by BleepingComputer, a Reddit user posted a screenshot to the r/youtube subreddit showing the message "Video player will be blocked after 3 videos."

The message further states that YouTube detected the user had an ad blocker installed, and then offered the option to either allow YouTube ads or try YouTube Premium, the $11.99 ad-free subscription service. The service's family plan recently saw a bump in price from $17.99 to $22.99 a month. "Ads allow YouTube to stay free for billions of users worldwide," the message reads.

A YouTube spokesperson confirmed to Gizmodo that it was running a "small experiment globally that urges viewers with ad blockers enabled to allow ads on YouTube or try YouTube Premium." The spokesperson added that "Ad blocker detection is not new, and other publishers regularly ask viewers to disable ad blockers."


Original Submission

posted by janrinok on Tuesday July 04 2023, @12:04PM   Printer-friendly
from the Government-hiding-alien-contact dept.

https://earthsky.org/space/interstellar-meteor-papua-new-guinea-2014-u-s-space-command/

In 2019, two researchers from Harvard University – Amir Siraj and Avi Loeb, both of whom had published on 'Oumuamua and Comet Borisov earlier – also wrote a study of this meteor, suggesting its interstellar origins. If true, then this meteor – which predates both 'Oumuamua and Comet Borisov by a few years – would be the first known interstellar object.

https://www.hindustantimes.com/world-news/harvard-scientist-avi-loeb-claims-collected-remains-of-extraterrestrial-technology-from-bottom-of-the-pacific-101688188241635.html

Deep-sea explorers found 50 spherules–molten droplets, about half a millimetre in diameter.

Loeb's team collected 35 milligrams of this promising material by dragging a large magnetic sled across the surface of the ocean. The astrophysicist believes that the spherules are most likely made from a steel-titanium alloy

"The spherules were found primarily along the most likely path of IM1 and not in control regions far from it," read his blog. "In the coming weeks, we will analyze their elemental and isotopic composition and report our data in a paper submitted to a peer-reviewed journal."

https://avi-loeb.medium.com/summary-of-the-successful-interstellar-expedition-61ff4467070d

These sub-millimeter-sized spheres, which appear under a microscope as beautiful metallic marbles, were concentrated along the expected path of IM1 — about 85 kilometers off the coast of Manus Island in Papua New Guinea.

-------

It's just un-spectacular enough to be believable.


Original Submission

posted by janrinok on Tuesday July 04 2023, @07:17AM   Printer-friendly
from the all-the-power-to-the-government dept.

France's browser-based website blocking proposal will set a disastrous precedent for the open internet

In a well-intentioned yet dangerous move to fight online fraud, France is on the verge of forcing browsers to create a dystopian technical capability. Article 6 (para II and III) of the SREN Bill would force browser providers to create the means to mandatorily block websites present on a government provided list. Such a move will overturn decades of established content moderation norms and provide a playbook for authoritarian governments that will easily negate the existence of censorship circumvention tools.

While motivated by a legitimate concern, this move to block websites directly within the browser would be disastrous for the open internet and disproportionate to the goals of the legal proposal – fighting fraud. It will also set a worrying precedent and create technical capabilities that other regimes will leverage for far more nefarious purposes. Leveraging existing malware and phishing protection offerings rather than replacing them with government provided, device level block-lists is a far better route to achieve the goals of the legislation.

[...] Browsers have played a critical role in the growth of the web by serving as user agents that mediate our experiences with the internet. This role, which Mozilla has been an integral actor in for over 25 years via Firefox, is based on some fundamental presumptions that enable browsers to focus on serving the interests of their users while keeping content regulation decisions further up the chain with either network intermediaries (such as ISPs) or service providers (websites).

The two most commonly used malware and phishing protection systems in the industry are Google's Safe Browsing and Microsoft's Smart Screen, where Mozilla (along with Apple, Brave, and many others) use Google's Safe Browsing. The Safe Browsing service has been around since at least 2005 and currently protects close to half the world's online population on various devices and software. It covers malware, unwanted software, and social engineering (phishing and other deceptive sites). It also has broad policies that are fairly robust and is also available via a free API, which makes it a more cost effective way for organisations to protect users.

Firefox has used Google's Safe Browsing offering for more than a decade and has a unique, privacy preserving implementation that protects user privacy while simultaneously preventing them from becoming victims of malware and phishing. This setting can also be turned off by users at any time, leaving them in control of their experience on the web.

It might seem that current malware and phishing protection industry practices are not so different from the French proposal. This is far from the truth, where the key differentiating factor is that they do not block websites but merely warn users about the risks and allow them to access the websites if they choose to accept it. No such language is present in the current proposal, which is focused on blocking. Neither are there any references to privacy preserving implementations or mechanisms to prevent this feature from being utilized for other purposes. In fact, a government being able to mandate that a certain website not open at all on a browser/system is uncharted territory and even the most repressive regimes in the world prefer to block websites further up the network (ISPs, etc.) so far.


Original Submission

posted by hubie on Tuesday July 04 2023, @02:38AM   Printer-friendly
from the I-silenced-of-that-annoying-alarm-for-you dept.

Janitor heard 'annoying alarms' and turned off freezer, ruining 20 years of school research worth $1 million, lawsuit says:

A university janitor who turned off a freezer after hearing multiple "annoying alarms," ruined more than 20 years of research, according to a lawsuit filed against his employer by Rensselaer Polytechnic Institute in upstate New York.

[...] The lab's freezer contained over 20 years of research, including cell cultures and samples, to which a "small temperature fluctuation of three degrees would cause catastrophic damage," according to the lawsuit filed with the Rensselaer County Supreme Court.

[...] The lawsuit states that cell cultures and specimens in the freezer needed to be maintained at -80 degrees Celsius and a small fluctuation of 3 degrees would cause damage, so alarms would sound if the temperature increased to -78 degrees or decreased to -82 degrees.

K.V. Lakshmi, a professor and director of the school's Baruch '60 Center for Biochemical Solar Energy Research who oversaw the research, noticed the freezer alert went off on or around September 14, 2020, because its temperature had risen to -78 degrees, according to the suit.

Despite the alarm, Lakshmi and her team determined that the cell samples would be safe until emergency repairs could be done, the suit said. While Lakshmi waited for the freezer's manufacturer to come perform repairs, her team added a safety lock box around the freezer's outlet and socket. A warning was posted on the freezer, according to the court filing.

[...] But, on September 17, the janitor heard what he later called "annoying alarms," according to the suit. In apparent attempt to be helpful, he flipped the circuit breakers, which provided electricity to the freezer, mistakenly turning them from "on" to "off," according to the lawsuit. It said the freezer's temperature rose to -32 degrees Celsius.

The next day, research students found the freezer switched off and despite attempts to preserve the research, a majority of the cultures were "compromised, destroyed, and rendered unsalvageable demolishing more than twenty years of research," the lawsuit states.


Original Submission

posted by janrinok on Monday July 03 2023, @09:52PM   Printer-friendly

Rocky Strikes Back At Red Hat:

The world of Linux has seen some disquiet over recent weeks following the decision of Red Hat to restrict source code distribution for Red Hat Enterprise Linux (RHEL) to only their paying customers. We're sure that there will be plenty of fall-out to come from this news, but what can be done if your project relies upon access to those Red Hat sources?

The Red-Hat-derived Rocky Linux distro relies on access to RHEL source, so the news could have been something of a disaster. Fortunately for Rocky users though, they appear to have found a reliable way to bypass the restriction and retain access to those RHEL sources. Red Hat would like anyone wanting source access to pay them handsomely for the privilege, but the Rocky folks have spotted a way to bypass this. Using readily available cloud images they can spin up a RHEL system and use it to download their sources, and they can do this as an automated process.

We covered this story as it unfolded last week, and it seemed inevitable then that something of this nature would be found, as for all Red Hat's wishes a GPL-licensed piece of code can't be prevented from being shared. So Rocky users and the wider community will for now retain access to the code, but will Red Hat strike back? It's inevitable that there will be a further backlash from the community against any such moves, but will Red Hat be foolhardy enough to further damage their standing in this regard?


Original Submission

posted by janrinok on Monday July 03 2023, @05:06PM   Printer-friendly

Not the iPhone maker's first think-of-the-children rodeo:

Apple has joined the rapidly growing chorus of tech organizations calling on British lawmakers to revise the nation's Online Safety Bill – which for now is in the hands of the House of Lords – so that it safeguards strong end-to-end encryption.

"End-to-end encryption is a critical capability that protects the privacy of journalists, human rights activists, and diplomats," Apple argued in a statement to the media.

"It also helps everyday citizens defend themselves from surveillance, identity theft, fraud, and data breaches. The Online Safety Bill poses a serious threat to this protection, and could put UK citizens at greater risk."

Apple, you may remember, announced in December 2022 that it will provide end-to-end encryption (E2EE) for most iCloud services.

"Apple urges the government to amend the bill to protect strong end-to-end encryption for the benefit of all," the iGiant's statement on the internet bill continued.

[...] As the draft law is currently written, the UK's communications watchdog Ofcom will have the power to instruct chat app makers and other tech companies to monitor conversations and posts for child sexual abuse material and terrorism content. Such data should be blocked or deleted when found, and potentially even reported to the cops, the government hopes.

If that doesn't lead to apps watering down or backdooring their E2EE so that data can be inspected in transit, it may bring about automated on-device scanning, which could end up censoring people's private chats or leaking them to the authorities – whether illegal activity was correctly or incorrectly detected. Such technology would be government-accredited, which means the app makers may have little choice over its eventual implementation.

Under that regime, an app or platform can't really say it offers truly strong E2EE on all messages if there's a chance those messages can be silently inspected by someone or some system outside the private conversation. There's a concern this all starts with tackling child abuse and terrorists – something with which the population won't generally have a problem – but will later lead to broader surveillance and censorship. It smacks of a government fed up with not being able to peer into private chatter whenever it feels necessary.

The Open Rights Group has a paper on the proposals here [PDF] if you want to read more about it. "According to an expert legal opinion, this bill would create the power to mandate some of broadest surveillance powers in any Western democracy," the body wrote in that document.

In February, encrypted chat service Signal said it will stop operating in the UK if the British government goes ahead with its Online Safety Bill as it stands.

And in April, other E2EE comms platforms Element, Session, Threema, Viber, WhatsApp, and Wire urged UK lawmakers to rethink the bill instead of "weakening encryption, undermining privacy, and introducing the mass surveillance of people's private communications."


Original Submission

posted by janrinok on Monday July 03 2023, @12:19PM   Printer-friendly

The quantum equivalent to shooting your own feet:

A few weeks ago, Iran broke through worldwide media due to its announcement that the country had successfully developed and deployed quantum computing products to aid in its military operations. But even as Iran's Rear Admiral Habibollah Sayyari smiled at the cameras present in the announcement, the tech world was quick to notice that the gold-plaqued board being showcased as an example of the country's work on quantum computing was nothing more than an Amazon-available, ARM-based FPGA (Field-Programable Gate Array) development board.

It seems Iran took a bit longer than one would expect to actually run the numbers on its "quantum computing product." Only recently, the country issued an official withdrawal statement admitting that there was no quantum at all to its quantum announcement.

"The unveiling of the FPGA board in the said conference has conveyed this false mentality to the country's media space that the said board is a quantum processor, which was not the case," said the research vice chancellor for Imam Khomeini University (machine translation via Tasnim News). Note that the issue isn't with the announcement itself and how it was worded. Apparently, the issue was with the country's media.

Even so, the research vice chancellor insisted that Iran is indeed looking into quantum computing as an aid for its armed forces' missions, adding that "the principle of the problem of the proposed algorithm, dealing with the disturbance of surface vessels' positioning systems, is important and approved for the promotion of maritime security."

To be fair, FPGAs can be (and often are) paired with quantum computing elements - they're usually deployed in quantum control mechanisms, bridging the gap between standard computing (like the one that's powering your current reading experience) and quantum computing (and if you're reading this in a quantum computer, do make sure to leave us a note).

So the ARM development board could, perhaps, have been truly used for quantum computing research at some point. Even so, there's a difference between treading the quantum waters with an FPGA dev board and actually manufacturing and deploying devices such as Intel's own Tunnel Falls Quantum Processing Unit (QPU) or IBM's Quantum System One. But Iran's leadership apparently thought it best to reap the (now meagre and questionable) geopolitical rewards of throwing its hat onto the quantum computing ring.

That might've been a bad move - but only Iran's leadership knows for sure.


Original Submission

posted by janrinok on Monday July 03 2023, @07:32AM   Printer-friendly

http://www.righto.com/2023/07/the-complex-history-of-intel-i960-risc.html

The Intel i960 was a remarkable 32-bit processor of the 1990s with a confusing set of versions. Although it is now mostly forgotten (outside the many people who used it as an embedded processor), it has a complex history. It had a shot at being Intel's flagship processor until x86 overshadowed it. Later, it was the world's best-selling RISC processor. One variant was a 33-bit processor with a decidedly non-RISC object-oriented instruction set; it became a military standard and was used in the F-22 fighter plane. Another version powered Intel's short-lived Unix servers. In this blog post, I'll take a look at the history of the i960, explain its different variants, and examine silicon dies. This chip has a lot of mythology and confusion (especially on Wikipedia), so I'll try to clear things up.

The ancestry of the i960 starts in 1975, when Intel set out to design a "micro-mainframe", a revolutionary processor that would bring the power of mainframe computers to microprocessors. This project, eventually called the iAPX 432, was a huge leap in features and complexity. Intel had just released the popular 8080 processor in 1974, an 8-bit processor that kicked off the hobbyist computer era with computers such as the Altair and IMSAI. However, 8-bit microprocessors were toys compared to 16-bit minicomputers like the PDP-11, let alone mainframes like the 32-bit IBM System/370. Most companies were gradually taking minicomputer and mainframe features and putting them into microprocessors, but Intel wanted to leapfrog to a mainframe-class 32-bit processor. The processor would make programmers much more productive by bridging the "semantic gap" between high-level languages and simple processors, implementing many features directly into the processor.

The 432 processor included memory management, process management, and interprocess communication. These features were traditionally part of the operating system, but Intel built them in the processor, calling this the "Silicon Operating System". The processor was also one of the first to implement the new IEEE 754 floating-point standard, still in use by most processors. The 432 also had support for fault tolerance and multi-processor systems. One of the most unusual features of the 432 was that instructions weren't byte aligned. Instead, instructions were between 6 and 321 bits long, and you could jump into the middle of a byte. Another unusual feature was that the 432 was a stack-based machine, pushing and popping values on an in-memory stack, rather than using general-purpose registers.


Original Submission

posted by janrinok on Monday July 03 2023, @02:49AM   Printer-friendly

Potential Genetic Markers of Multiple Sclerosis Severity

Genes Linked to Most Severe Symptoms of Multiple Sclerosis:

In a bid to determine factors linked to the most debilitating forms of multiple sclerosis (MS), Johns Hopkins Medicine researchers say they have identified three so-called "complement system" genes that appear to play a role in MS-caused vision loss. The researchers were able to single out these genes — known to be integral in the development of the brain and immune systems — by using DNA from MS patients along with high-tech retinal scanning.

If further studies confirm the researcher's findings, reported in the September issue of Brain, the investigators say they could serve as markers for monitoring and predicting progression and severity of MS, an unpredictable disorder in which the immune system eats away at protective insulation around nerve cells. This approach, the researchers say, represents the beginning of precision medicine for MS and may ultimately allow designer therapies, as is being done for specific cancers.

In MS, nerve communication breaks down over time between the brain and the rest of the body, causing chronic and/or intermittent muscle spasms, tremors, imbalance, pain, numbness, depression, loss of bladder or bowel control and vision problems. MS is more common in women, and symptoms vary widely.

"Although we have treatments for the type of MS where symptoms come on in bursts — called relapsing-remitting MS — we don't have any way to stop the kind of MS in which the nerve cells start to die, known as progressive MS," says Peter Calabresi, M.D., professor of neurology and neuroscience at the Johns Hopkins University School of Medicine and co-director of the Johns Hopkins Precision Medicine Center of Excellence for Multiple Sclerosis. "We believe that our study opens up a new line of investigation targeting complement genes as a potential way to treat disease progression and nerve cell death."

For their study, the researchers used optical coherence tomography -- an imaging technique that allowed the researchers to look at the back of each patient's eyes and assess damage to the nerve cells in the retina -- in 374 patients with all types of MS. The patients were an average of 43 years old and mostly women (78%).

The investigators recruited these patients and performed imaging every few years from 2010 to 2017, yielding an average of 4.6 scans per participant over the course of the study. The scans were used to measure thinning of the layer of the nerve cells — known as ganglion cells — in the retina over time. The average rate of deterioration was a loss of 0.32 micrometers of tissue per year in each patient.

Then, using blood samples from the patients to collect their DNA, the researchers hunted for genetic mutations in those people with the fastest deterioration rates and identified 23 such DNA variations that mapped to the complement gene C3.

Next, to search for genes further linked to vision loss, they performed an analysis of an existing clinical trial group of another 835 people with MS, of whom 74% were women, and whose average age was 40. Each participant underwent periodic vision testing about every year to distinguish their ability to detect contrast — finer and finer shades that distinguish light versus dark. The test requires the person to read five letters in a row as with a typical vision chart test, as well as separate vison charts with faint (low contrast) letters that simulate vision in low light (dusk or dark).

Using DNA from the blood samples of these 835 participants, the researchers identified specific genetic changes in two complement genes, C1QA and CR1, linked to those people with the most rapidly declining ability to distinguish letters with less contrast. Patients with genetic changes in the C1QA gene were 71% more likely to develop difficulty detecting visual contrast, whereas those with genetic changes in the CR1 gene were at 40% increased risk for developing a reduced ability to detect contrast.

These complement genes found to be linked with severity of MS vision loss hold the genetic instructions for making complement proteins.

Journal Reference:
Fitzgerald, Kathryn C, Kim, Kicheol, Smith, Matthew D, et al. Early complement genes are associated with visual system degeneration in multiple sclerosis, Brain (DOI: 10.1093/brain/awz188)

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