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posted by takyon on Monday February 05 2018, @11:55PM   Printer-friendly
from the Lamarck-wasn't-(all)-wrong dept.

Is evolutionary science due for a major overhaul – or is talk of 'revolution' misguided?

When researchers at Emory University in Atlanta trained mice to fear the smell of almonds (by pairing it with electric shocks), they found [DOI: 10.1038/nn.3594] [DX], to their consternation, that both the children and grandchildren of these mice were spontaneously afraid of the same smell. That is not supposed to happen. Generations of schoolchildren have been taught that the inheritance of acquired characteristics is impossible. A mouse should not be born with something its parents have learned during their lifetimes, any more than a mouse that loses its tail in an accident should give birth to tailless mice.

If you are not a biologist, you'd be forgiven for being confused about the state of evolutionary science. Modern evolutionary biology dates back to a synthesis that emerged around the 1940s-60s, which married Charles Darwin's mechanism of natural selection with Gregor Mendel's discoveries of how genes are inherited. The traditional, and still dominant, view is that adaptations – from the human brain to the peacock's tail – are fully and satisfactorily explained by natural selection (and subsequent inheritance). Yet as novel ideas flood in from genomics, epigenetics and developmental biology, most evolutionists agree that their field is in flux. Much of the data implies that evolution is more complex than we once assumed.

Some evolutionary biologists, myself included, are calling for a broader characterisation of evolutionary theory, known as the extended evolutionary synthesis (EES). A central issue is whether what happens to organisms during their lifetime – their development – can play important and previously unanticipated roles in evolution. The orthodox view has been that developmental processes are largely irrelevant to evolution, but the EES views them as pivotal. Protagonists with authoritative credentials square up on both sides of this debate, with big-shot professors at Ivy League universities and members of national academies going head-to-head over the mechanisms of evolution. Some people are even starting to wonder if a revolution is on the cards. 

Let's return to the almond-fearing mice. The inheritance of an epigenetic mark transmitted in the sperm is what led the mice's offspring to acquire an inherited fear. In 2011, another extraordinary study [open, DOI: 10.1016/j.cell.2011.10.042] [DX] reported that worms responded to exposure to a nasty virus by producing virus-silencing factors – chemicals that shut down the virus – but, remarkably, subsequent generations epigenetically inherited these chemicals via regulatory molecules (known as 'small RNAs'). There are now hundreds of such studies [DOI: 10.1098/rsfs.2016.0135] [DX], many published in the most prominent and prestigious journals. Biologists dispute whether epigenetic inheritance is truly Lamarckian or only superficially resembles it, but there is no getting away from the fact that the inheritance of acquired characteristics really does happen.

By Popper's reasoning, a single experimental demonstration of epigenetic inheritance – like a single black sheep – should suffice to convince evolutionary biologists that it's possible. Yet, by and large, evolutionary biologists have not rushed to change their theories. Rather, as Lakatos anticipated, we have come up with auxiliary hypotheses that allow us to retain our long-held beliefs (ie, that inheritance is pretty much explained by the transmission of genes across generations). These include the ideas that epigenetic inheritance is rare, that it does not affect functionally important traits, that it is under genetic control, and that it is too unstable to underpin the spread of traits through selection.

Unfortunately for the traditionalists, none of these attempts to bracket epigenetic inheritance look credible. It is now known to be widespread in nature [DOI: 10.1098/rsfs.2016.0135] [DX], with more and more examples appearing every day. It affects [DOI: 10.1126/science.1248127] [DX] functionally important features such as fruit size, flowering time and root growth in plants – and while only a fraction of epigenetic variants are adaptive, that's no less true of genetic variation, so it's hardly grounds for dismissal. In some systems where rates of epigenetic change have been measured carefully, such as the plant Arabidopsis thaliana, the pace has been found [open, DOI: 10.1073/pnas.1424254112] [DX] to be low enough to be selected and lead to cumulative evolution. Mathematical models have shown [open, DOI: 10.1086/660911] [DX] that systems with epigenetic inheritance evolve differently from those solely reliant on genetic inheritance – for instance, selection on epigenetic marks can cause changes in gene frequencies. There's no longer any doubt that epigenetic inheritance pushes us to think about evolution in a different way.

Is Lamarck laughing from the grave?


Original Submission

posted by janrinok on Monday February 05 2018, @10:32PM   Printer-friendly
from the how-many-of-us-remember-it-now? dept.

The Berlin wall was erected on 13 August 1961. It was breached on 9 November 1989, after 28 years, 2 months and 27 days (10315 days, to be exact). Counting forward another 28 years, 2 months and 27 days (or just 10315 days, you get the same answer) takes us to tomorrow, 5 February 2018.

Below is the blog entry I posted on the twentieth anniversary of the Fall of the Wall, in 2009. Since then, I have continued to enjoy visiting Berlin; and I always pay my respects to the Wall and its memories, for me and for many others.

https://nwhyte.livejournal.com/2959427.html

[Editor's Comment: I too had the pleasure of serving in Berlin on 2 separate tours of duty, alongside US and French colleagues. The city was vibrant and full of places to see and things to do. However, I never lost the feeling that we lived in a very restricted environment. I was one of the fortunate ones in that my military duties meant I also had the opportunity to work in what was then East Germany. I'm glad that those days are long gone.]


Original Submission

posted by janrinok on Monday February 05 2018, @08:45PM   Printer-friendly
from the eye-see-what-you-did-there dept.

Intel is launching plain-looking smartglasses that beam a monochrome red image directly into your retina using a laser. There are no cameras on the device:

Intel has launched an impressively light, regular-looking set of smart glasses called Vaunt, confirming rumors from Bloomberg and others. Seen by The Verge, they have plastic frames and weigh under 50 grams, a bit more than regular eyeglasses but much less than Google Glass, for example. The electronics are crammed into the stems and control a very low-powered, class one laser that shines a red, monochrome 400 x 150 pixel image into your eye. Critically, the glasses contain no camera, eliminating the "big brother" vibe from Glass and other smart glasses.


Original Submission

posted by takyon on Monday February 05 2018, @07:11PM   Printer-friendly
from the case-cracked dept.

The UK high court has finally ruled on the extradition of Lauri Love, the Finnish-British student accused of cracking U.S. government websites. He will not be extradited to face trial in America. The court accepted both of the main arguments that there is no reason he cannot not be tried in England and that he might suffer serious damage to his health if he were extradited.

Source: Hacking Suspect Lauri Love Wins Appeal Against Extradition to US

Previously: Lauri Love to be Extradited to the U.S.
Lauri Love's Appeal Will be Heard in the UK on November 28th and 29th


Original Submission

posted by martyb on Monday February 05 2018, @05:49PM   Printer-friendly
from the lawyers-will-be-the-only-winners dept.

The Waymo v. Uber jury trial is set to begin Monday and is expected to end during the week of February 19. It's not a matter of good vs. evil:

"The trial will be a trial on Waymo's claims of trade secret misappropriation, not a trial on Uber's litigation practices or corporate culture," Judge Alsup wrote on January 30.

[...] Alsup went on to say that both sides have engaged in "half-truths and other slick litigation conduct" and that Waymo, which has "whined—often without good reason—at every turn in this case," essentially needs to put up or shut up.

"To repeat, the central issue in this case remains whether or not Uber misappropriated Waymo's trade secrets, not whether or not Uber is an evil corporation," the judge continued. "Waymo's decision to devote so much time and effort to pursuing matters with so little connection to the merits raises the troubling possibility that Waymo is unwilling or unable to prove up a solid case on the merits and instead seeks to inflame the jury against Uber with a litany of supposed bad acts."

Also at The Verge and FT (paywalled).

Previously: Waymo v. Uber Continues, Will Not Move to Arbitration
Waymo's Case Against Uber "Shrinks" After Trade Secret Claim Thrown Out
Uber v. Waymo Trial Delayed Because Uber Withheld Evidence
A Spectator Who Threw A Wrench In The Waymo/Uber Lawsuit

Related: Uber Letter Alleges Surveillance on Politicians and Competitors
The Fall of Uber CEO Travis Kalanick
Waymo Orders Thousands More Chrysler Pacifica Minivans for Driverless Fleet


Original Submission

posted by Fnord666 on Monday February 05 2018, @04:18PM   Printer-friendly
from the no-tipping-please dept.

Submitted via IRC for TheMightyBuzzard

Wanted criminals have already been tracked using biometric imaging, but now an Irish company is targeting dairy cows with a new form of facial recognition.

Irish company Cainthus appears to be ‘raising the steaks’ in facial recognition with an unusual plan to roll out the technology to dairy farms around the world.

The data solutions company based in Dublin has partnered with agriculture giant Cargill to produce a predictive imaging system that can identify cows from their facial features and hide patterns. The software will also provide dairy farmers with data on their animal’s temperature and food intake.

I'm definitely bullish on this idea.

Source: https://www.rt.com/news/417752-cow-facial-recognition-cargill/


Original Submission

posted by Fnord666 on Monday February 05 2018, @02:45PM   Printer-friendly
from the things-that-go-up-[in-flames] dept.

It's rare that the forthcoming publishing of a book fills me with excitement and anticipation. Doubly rare when said book has been out of print for decades. Elon Musk may have popularized the term RUD (Rapid Unscheduled Disassembly), but his experiences can barely hold a candle to the tales told by John D Clark, author of Ignition! An Informal History of Liquid Rocket Propellants. Read on for the scoop from Ars Technica:

Often hilarious, always informative, this history of rocket science is a must-read.

It's rare that a book about as high-minded and serious a topic as rocket science manages to be both highly informative and laugh-out-loud funny. But if there's a better way to describe John Clark's Ignition!, I've yet to discover it. A cult classic among chemists, many of the rest of us discovered the book via one of Derek Lowe's tales of hilariously scary chemicals.

[...] Rutgers University Press has decided to dust it off and reissue it. From May it will finally be possible to put a physical copy on one's bookshelf. And honestly, if you've got any interest in chemistry—particularly the branch of it involving violent, energetic, and occasionally explosive reactions—it's a book you need to read.

Ignition! is a history of liquid rocket propellants, but it's also a history of cold war and the space race, told from a particular point of view. Clark was the chief chemist at a rocket lab in New Jersey, operated first by the US Navy, then US Army. He was a central figure in what was a relatively small field, one with a definite purpose. This wasn't science just for science's sake, but a quest to find new oxidizers and fuels for rocket engines, to make better missiles or space probes.

The propellants being asked for would have to be liquids throughout a range of temperatures, and preferably completely innocuous and easily stored until reacting violently together upon combination. However, if you guessed that many of the chemicals suitable for energetic reactions in a rocket often tend to react energetically in many other situations—often with no provocation at all—Clark's tales of "catastrophic self-disassembly" might not be entirely surprising.

Pricing ranges from $24.95 to $95.00 with pre-orders being accepted now. A PDF is available on February 14th; other formats and a reduced-price PDF is available on May 15th.

Read on for a sample passage from Chapter 6 of Ignition!:

While all of this was going on there were a lot of people who were not convinced that peroxide, or acid, or nitrogen tetroxide was the last word in storable oxidizers, nor that something a bit more potent couldn't be found. An oxygen-based oxidizer is all very well, but it seemed likely that one containing fluorine would pack an impressive wallop. And so everybody started looking around for an easily decomposed fluorine compound that could be used as a storable oxidizer.

[...] Chlorine trifluoride, ClF3, or "CTF" as the engineers insist on calling it, is a colorless gas, a greenish liquid, or a white solid. It boils at 12° (so that a trivial pressure will keep it liquid at room temperature) and freezes at a convenient -76°. It also has a nice fat density, about 1.81 at room temperature.

It is also quite probably the most vigorous fluorinating agent in existence—much more vigorous than fluorine itself. Gaseous fluorine, of course, is much more dilute than the liquid ClF3, and liquid fluorine is so cold that its activity is very much reduced.

All this sounds fairly academic and innocuous, but when it is translated into the problem of handling the stuff, the results are horrendous. It is, of course, extremely toxic, but that's the least of the problem. It is hypergolic with every known fuel, and so rapidly hypergolic that no ignition delay has ever been measured. It is also hypergolic with such things as cloth, wood, and test engineers, not to mention asbestos, sand, and water — with which it reacts explosively. It can be kept in some of the ordinary structural metals — steel, copper, aluminum, etc. — because of the formation of a thin film of insoluble metal fluoride which protects the bulk of the metal, just as the invisible coat of oxide on aluminum keeps it from burning up in the atmosphere. If, however, this coat is melted or scrubbed off, and has no chance to reform, the operator is confronted with the problem of coping with a metal-fluorine fire. For dealing with this situation, I have always recommended a good pair of running shoes. And even if you don't have a fire, the results can be devastating enough when chlorine trifluoride gets loose, as the General Chemical Co. discovered when they had a big spill.

[...] It happened at their Shreveport, Louisiana, installation, while they were preparing to ship out, for the first time, a one-ton steel cylinder of CTF. The cylinder had been cooled with dry ice to make it easier to load the material into it, and the cold had apparently embrittled the steel. For as they were maneuvering the cylinder onto a dolly, it split and dumped one ton of chlorine trifluoride onto the floor. It chewed its way through twelve inches of concrete and dug a three-foot hole in the gravel underneath, filled the place with fumes which corroded everything in sight, and, in general, made one hell of a mess. Civil Defense turned out, and started to evacuate the neighborhood, and to put it mildly, there was quite a brouhaha before things quieted down. Miraculously, nobody was killed, but there was one casualty — the man who had been steadying the cylinder when it split. He was found some five hundred feet away, where he had reached Mach 2 and was still picking up speed when he was stopped by a heart attack.


Original Submission

posted by Fnord666 on Monday February 05 2018, @01:12PM   Printer-friendly
from the stimulating-research dept.

Our immune cells can destroy tumors, but sometimes they need a kick in the pants to do the job. A study in mice describes a new way to incite these attacks by injecting an immune-stimulating mixture directly into tumors. The shots trigger the animals' immune system to eliminate not only the injected tumors, but also other tumors in their bodies.

"This is a very important study," says immunologist Keith Knutson of the Mayo Clinic in Jacksonville, Florida, who wasn't connected to the research. "It provides a good pretext for going into humans."

To bring the wrath of the immune system down on tumors, researchers have tried shooting them up with a variety of molecules and viruses. So far, however, almost every candidate they've tested hasn't worked in people.

Hoping to develop a more potent approach, medical oncologist Ron Levy of Stanford University in Palo Alto, California, and colleagues used mice to test the cancer-fighting capabilities of some 20 molecules, including several types of antibodies that activate immune cells. The researchers first induced tumors by inserting cancer cells just below the skin at two different locations on the animals' abdomens. After tumors started growing at both sites, the scientists injected the molecules, alone or in combination, into one tumor in each mouse. They then tracked the responses of both tumors.

A pair of molecules—a type of DNA snippet called CpG and an antibody against the immune cell protein OX40—produced the best results. "On their own, they do almost nothing, but the combination is synergistic," Levy says. When the researchers injected the two molecules into mouse tumors, they disappeared in less than 10 days. In less than 20 days, the noninjected tumors had also vanished, the team reports online today in Science Translational Medicine.

http://www.sciencemag.org/news/2018/01/injection-helps-immune-system-obliterate-tumors-least-mice

Idit Sagiv-Barfi, et. al. Eradication of spontaneous malignancy by local immunotherapy. Science Translational Medicine. DOI: 10.1126/scitranslmed.aan4488


Original Submission

posted by Fnord666 on Monday February 05 2018, @11:39AM   Printer-friendly
from the give-me-network-choices dept.

Ars Technica is reporting on San Francisco's initial steps to create a citywide fiber-to-the-premise (FTTP) open-access network where ISPs compete for customers.

According to Ars Technica:

San Francisco is trying to find network providers to build a city-wide, gigabit fiber Internet service with mandated net neutrality and consumer privacy protections. It would be an open-access network, allowing multiple ISPs to offer service over the same lines and compete for customers.

The city yesterday issued a Request for Qualifications (RFQ) to find companies that are qualified "to design, build, finance, operate, and maintain a ubiquitous broadband FTTP [fiber-to-the-premises] network that permits retail service providers to lease capacity on the network." The project would also involve a free Wi-Fi service for city parks, city buildings, major thoroughfares, and visitor areas. Low-income residents would qualify for subsidies that make home Internet service more affordable.

ISPs offering service over the network would not be allowed to block or throttle lawful Internet traffic or engage in paid prioritization. ISPs would also need customers' opt-in consent "prior to collecting, using, disclosing, or permitting access to customer personal information or information about a customer's use of the network."

Could this be the first major US metropolitan area to create a real free market in broadband Internet? Do any Soylentils have similar municipal networks?


Original Submission

posted by Fnord666 on Monday February 05 2018, @10:06AM   Printer-friendly
from the power-distribution dept.

Submitted via IRC for Bytram

But now instead of being a large centralized battery system using Tesla's Powerpacks, the new project announced today is using Tesla's residential battery system, the Powerwall, to create decentralized energy storage, which basically results in creating a massive virtual power plant.

South Australia Premier Jay Weatherill announced the deal today – the biggest of its kind by far.

The 50,000 homes in the state will be fitted with 5 kW solar arrays and 13.5 kWh Tesla Powerwall 2 battery systems.

It will result in at least 650 MWh of energy storage capacity distributed in the state.

Tesla said in a statement:

"When the South Australian Government invited submissions for innovation in renewables and storage, Tesla's proposal to create a virtual power plant with 250 megawatts of solar energy and 650 megawatt hours of battery storage was successful. A virtual power plant utilises Tesla Powerwall batteries to store energy collectively from thousands of homes with solar panels. At key moments, the virtual power plant could provide as much capacity as a large gas turbine or coal power plant."

It will function much like Tesla's giant Powerpack system, which charges when demand and electricity rates are low and discharges when demand and prices are high.

Aims to install 5 kW solar arrays and 13.5 kWh Tesla Powerwall 2 battery systems in 50,000 homes by 2022.

Source: https://electrek.co/2018/02/04/tesla-powerwall-solar-virtual-power-plant/


Original Submission

posted by Fnord666 on Monday February 05 2018, @08:33AM   Printer-friendly
from the holy-replacements-batman dept.

https://www.wsj.com/articles/popes-china-calculation-clashes-with-image-as-champion-of-oppressed-1517600924
http://archive.is/8KMX1

Pope Francis ' recent decision to replace two Chinese bishops loyal to Rome with selectees of the country's Communist government, heralding his broader moves to reset the Vatican's ties with Beijing, has drawn cries of betrayal from advocates of the country's long-persecuted "underground" Catholic Church.

The pope's actions in China are characteristic of a leader who has repeatedly practiced realpolitik to achieve important goals. But they clash with Pope Francis' image among many Catholics and others as a defender of the oppressed—a profile likely to be further tested by his campaign to improve Vatican-China relations after seven decades of estrangement.

The pope has decided to recognize seven government-appointed Chinese bishops, according to a person familiar with the matter, in a major concession to Beijing in pursuit of warmer relations and—in the very long term—possible reestablishment of diplomatic ties broken in 1951. As part of that decision, Pope Francis has moved to replace two bishops loyal to the Vatican with prelates from China's state-controlled Catholic church.


Original Submission

posted by mrpg on Monday February 05 2018, @07:00AM   Printer-friendly
from the sugoi-ze! dept.

Souped-up sounding rocket lifts off from Japan with tiny satellite

A modified sounding rocket originally designed to loft science instruments on high-altitude suborbital arcs blasted off Saturday from the Uchinoura Space Center in southern Japan and soared into orbit to become the world's smallest satellite launcher.

[...] Standing just 31 feet (9.5 meters) tall and spanning around 20 inches (52 centimeters) in diameter, the SS-520-5 rocket was modest by launcher standards. With Saturday's successful flight, the solid-fueled booster became the smallest rocket to ever put an object in orbit around Earth.

A student-built shoebox-sized CubeSat named TRICOM 1R — weighing in at about 10 pounds (3 kilograms) — was mounted on top of the SS-520-5 rocket for liftoff from the Uchinoura Space Center in Japan's Kagoshima prefecture.

[...] The SS-520 is designed to propel more than 300 pounds (140 kilograms) of science research instrumentation to an altitude of nearly 500 miles (800 kilometers) for a few minutes of exposure to space before falling back to Earth. Engineers added a third stage on top of the basic SS-520 booster to give it the capability to reach orbital speeds of more than 17,000 mph (27,000 kilometers per hour).

Also at The Verge.

Related: Rocket Lab's Second "Electron" Rocket Launch Succeeds, Reaches Orbit


Original Submission

posted by Fnord666 on Monday February 05 2018, @05:36AM   Printer-friendly
from the common-sense dept.

Mathematician Keith Devlin writes about how the capabilities to work with maths have changed since the late 1960s. He summarizes what he considers to be the essential skills and knowledge that people can focus on as more and more is turned over to software.

The shift began with the introduction of the digital arithmetic calculator in the 1960s, which rendered obsolete the need for humans to master the ancient art of mental arithmetical calculation. Over the succeeding decades, the scope of algorithms developed to perform mathematical procedures steadily expanded, culminating in the creation of desktop and cloud-based mathematical computation systems that can execute pretty well any mathematical procedure, solving—accurately and in a fraction of a second—any mathematical problem formulated with sufficient precision (a bar that allows in all the exam questions I and any other math student faced throughout our entire school and university careers).

So what, then, remains in mathematics that people need to master? The answer is, the set of skills required to make effective use of those powerful new (procedural) mathematical tools we can access from our smartphone. Whereas it used to be the case that humans had to master the computational skills required to carry out various mathematical procedures (adding and multiplying numbers, inverting matrices, solving polynomial equations, differentiating analytic functions, solving differential equations, etc.), what is required today is a sufficiently deep understanding of all those procedures, and the underlying concepts they are built on, in order to know when, and how, to use those digitally-implemented tools effectively, productively, and safely.

Source : What Scientific Term or Concept Ought to be More Widely Known?


Original Submission

posted by Fnord666 on Monday February 05 2018, @03:16AM   Printer-friendly
from the HiFive-Unleashed dept.

Submitted via IRC for TheMightyBuzzard

Slowly but surely, RISC-V, the Open Source architecture for everything from microcontrollers to server CPUs is making inroads in the community. Now SiFive, the major company behind putting RISC-V c...

That's damned nifty but at a grand for a 1.5GHz system, I don't see them selling that many to consumers.

Source: https://hackaday.com/2018/02/03/sifive-introduces-risc-v-linux-capable-multicore-processor/


Original Submission

posted by Fnord666 on Monday February 05 2018, @12:55AM   Printer-friendly
from the the-emacs-of-the-internet dept.

Big news outlets stupidly sold their soul to Facebook. Desperate for the referral traffic Facebook dangled, they spent the past few years jumping through its hoops only to be cut out of the equation. Instead of developing an owned audience of homepage visitors and newsletter subscribers, they let Facebook brainwash readers into thinking it was their source of information.

Now Facebook is pushing into local news, but publishers should be wary of making the same crooked deal. It might provide more exposure and traffic for smaller outlets today, but it could teach users they only need to visit Facebook for local news in the future. Here's how Facebook retrained us over the past 12 years to drain the dollars out of news.

Source : How Facebook stole the news business


Original Submission