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The FDA has issued a public health advisory warning of deaths related to kratom (Mitragyna speciosa) and warning against using it to treat opioid withdrawal symptoms. The DEA attempted to temporarily regulate kratom as a schedule I drug in 2016, but stopped short of doing so after a public backlash. From FDA Commissioner Scott Gottlieb's statement on the advisory:
It's very troubling to the FDA that patients believe they can use kratom to treat opioid withdrawal symptoms. The FDA is devoted to expanding the development and use of medical therapy to assist in the treatment of opioid use disorder. However, an important part of our commitment to this effort means making sure patients have access to treatments that are proven to be safe and effective. There is no reliable evidence to support the use of kratom as a treatment for opioid use disorder. Patients addicted to opioids are using kratom without dependable instructions for use and more importantly, without consultation with a licensed health care provider about the product's dangers, potential side effects or interactions with other drugs.
There's clear data on the increasing harms associated with kratom. Calls to U.S. poison control centers regarding kratom have increased 10-fold from 2010 to 2015, with hundreds of calls made each year. The FDA is aware of reports of 36 deaths associated with the use of kratom-containing products. There have been reports of kratom being laced with other opioids like hydrocodone. The use of kratom is also associated with serious side effects like seizures, liver damage and withdrawal symptoms.
Given all these considerations, we must ask ourselves whether the use of kratom – for recreation, pain or other reasons – could expand the opioid epidemic. Alternatively, if proponents are right and kratom can be used to help treat opioid addiction, patients deserve to have clear, reliable evidence of these benefits.
I understand that there's a lot of interest in the possibility for kratom to be used as a potential therapy for a range of disorders. But the FDA has a science-based obligation that supersedes popular trends and relies on evidence. The FDA has a well-developed process for evaluating botanical drug products where parties seek to make therapeutic claims and is committed to facilitating development of botanical products than can help improve people's health. We have issued guidance on the proper development of botanical drug products. The agency also has a team of medical reviewers in the FDA's Center for Drug Evaluation and Research that's dedicated to the proper development of drug applications for botanicals. To date, no marketer has sought to properly develop a drug that includes kratom.
[...] As a physician and FDA Commissioner, I stand committed to doing my part to prevent illegal substances that pose a threat to public health from taking their grip on Americans. While we remain open to the potential medicinal uses of kratom, those uses must be backed by sound-science and weighed appropriately against the potential for abuse. They must be put through a proper evaluative process that involves the DEA and the FDA. To those who believe in the proposed medicinal uses of kratom, I encourage you to conduct the research that will help us better understand kratom's risk and benefit profile, so that well studied and potentially beneficial products can be considered. In the meantime, based on the weight of the evidence, the FDA will continue to take action on these products in order to protect public health.
The FDA Commissioner may want your help to study kratom, but you'll find it hard to do so as imports of the substance are being seized:
The FDA has exercised jurisdiction over kratom as an unapproved drug, and has also taken action against kratom-containing dietary supplements. To fulfill our public health obligations, we have identified kratom products on two import alerts and we are working to actively prevent shipments of kratom from entering the U.S. At international mail facilities, the FDA has detained hundreds of shipments of kratom. We've used our authority to conduct seizures and to oversee the voluntary destruction of kratom products. We're also working with our federal partners to address the risks posed by these imports. In response to a request from the Drug Enforcement Administration (DEA), the FDA has conducted a comprehensive scientific and medical evaluation of two compounds found in kratom. Kratom is already a controlled substance in 16 countries, including two of its native countries of origin, Thailand and Malaysia, as well as Australia, Sweden and Germany. Kratom is also banned in several states, specifically Alabama, Arkansas, Indiana, Tennessee and Wisconsin and several others have pending legislation to ban it.
Also at Reuters, STAT News, Reason, and the Washington Post (archive).
Previously: DEA Welcomes Kratom to the Schedule I List Beginning September 30
The Calm Before the Kratom Ban
Physicists from the Moscow Institute of Physics and Technology (MIPT) and Royal Holloway, University of London, have demonstrated an effect known as quantum wave mixing on an artificial atom. Their results, published in the journal Nature Communications, could help develop quantum electronics of an entirely new kind.
Researchers from MIPT's Laboratory of Artificial Quantum Systems led by Professor Oleg Astafiev teamed up with their British colleagues to examine a superconducting quantum system, which is physically equivalent to a single atom. Cooled to ultra-low temperatures, this device emitted and absorbed a single quanta of microwave radiation—the same way that an atom interacts with photons of light.
Artificial atoms, which are at the heart of this study, are a staple of quantum optics experiments. Physicists use these systems to investigate the processes that are otherwise hard to study, such as the emission and absorption of several photons. Whereas a real atom in a mirror cavity emits light in an arbitrary direction, a superconducting system radiates in a controlled way. This enabled the authors to detect the scattering of several light quanta on an artificial atom, or wave mixing.
In the output of the system described above, the researchers observed both source radiation and electromagnetic waves resulting from its interaction with the artificial atom. The frequencies of these waves were determined by the nature of the excitation involved. This pointed to the effect of quantum wave mixing, which had not been observed in systems of this kind before.
Cyber Security Challenge UK runs a series of online games that allow amateur cybersleuths and white-hat hackers to test their skills. Those who score well online are invited to a series of regional, in-person competitions. The top performers at these events are then invited to the annual three-day masterclass and team-based competition where they face a realistic scenario created by experts from the sponsoring companies.
Would you like to play a game?
Tesla has been sued by an employee for alleged racist harassment and termination for complaining:
Tesla Inc.'s production floor is a "hotbed for racist behavior," an African-American employee claimed in a lawsuit in which he alleged black workers at the electric carmaker suffer severe and pervasive harassment. The employee says he's one of more than 100 African-American Tesla workers affected and is seeking permission from a judge to sue on behalf of the group. He's seeking unspecified general and punitive monetary damages as well as an order for Tesla to implement policies to prevent and correct harassment.
[...] The lawsuit was filed on behalf of Marcus Vaughn, who worked in the Fremont factory from April 23 to Oct. 31. Vaughn alleged that employees and supervisors regularly used the "N word" around him and other black colleagues. Vaughn said he complained in writing to human resources and Musk and was terminated in late October for "not having a positive attitude."
Although customers who have reserved a Tesla Model 3 (at a cost of $1000) have seen their delivery dates pushed back, they apparently remain loyal to the company:
Even as the company led by Elon Musk struggles with manufacturing bottlenecks and pushes back production targets by at least a quarter, many reservation holders aren't budging. Bloomberg News contacted 20 consumers who paid deposits for the Model 3 and none had canceled their orders. Regardless of the concerns raised by slower output and an uncertain future for U.S. electric-car tax credits, Nomura analyst Romit Shah predicts the affinity for Tesla Inc. products will prevail. "We believe there is a real passion for the brand," Shah wrote in a report to clients that reiterated a $500 price target for Tesla shares, the highest on Wall Street. "It is bigger than loyalty because much of the enthusiasm comes from people who have never owned a Tesla. The only comparable we see is the iPhone."
Finally, Elon Musk says that the Tesla Semi Truck will be unveiled during a live webcast at 8 PM on Thursday, and that it will "blow your mind clear out of your skull and into an alternate dimension".
Previously: Elon Musk Says Tesla Pickup and Semi-Trucks Are Coming
Time to Bash Tesla Model 3
Tesla Discussing Autonomous Semi Truck Testing in Nevada
Tesla Fires Hundreds of Employees
Tesla Burns More Cash, Fails to Meet Production Targets
The U.S. Food and Drug Administration (FDA) has approved a "digital pill" that contains a sensor intended to track whether a patient has taken their medicine:
For the first time, the Food and Drug Administration has approved a digital pill — a medication embedded with a sensor that can tell doctors whether, and when, patients take their medicine. The approval, announced late on Monday, marks a significant advance in the growing field of digital devices designed to monitor medicine-taking and to address the expensive, longstanding problem that millions of patients do not take drugs as prescribed.
Experts estimate that so-called non-adherence or noncompliance to medication costs about $100 billion a year, much of it because patients get sicker and need additional treatment or hospitalization. "When patients don't adhere to lifestyle or medications that are prescribed for them, there are really substantive consequences that are bad for the patient and very costly," said Dr. William Shrank, chief medical officer of the health plan division at the University of Pittsburgh Medical Center.
Ameet Sarpatwari, an instructor in medicine at Harvard Medical School, said the digital pill "has the potential to improve public health," especially for patients who want to take their medication but forget. But, he added, "if used improperly, it could foster more mistrust instead of trust."
IBM Raises the Bar with a 50-Qubit Quantum Computer
IBM established a landmark in computing Friday, announcing a quantum computer that handles 50 quantum bits, or qubits. The company is also making a 20-qubit system available through its cloud computing platform.
IBM, Google, Intel, and a San Francisco startup called Rigetti are all currently racing to build useful quantum systems. These machines process information in a different way from traditional computers, using the counterintuitive nature of quantum physics.
The announcement does not mean quantum computing is ready for common use. The system IBM has developed is still extremely finicky and challenging to use, as are those being built by others. In both the 50- and the 20-qubit systems, the quantum state is preserved for 90 microseconds—a record for the industry, but still an extremely short period of time.
[...] IBM is also announcing an upgrade to its quantum cloud software system today. "We're at world record pace. But we've got to make sure non-physicists can use this," Gil says.
The announcement should perhaps be treated cautiously, though. Andrew Childs, a professor at the University of Maryland, points out that IBM has not published details of its system in a peer-reviewed journal. "IBM's team is fantastic and it's clear they're serious about this, but without looking at the details it's hard to comment," he says. Childs says the larger number of qubits does not necessarily translate to a leap in computational capability. "Those qubits might be noisy, and there could be issues with how well connected they are," he says.
Also at The Mercury News and SiliconANGLE.
Previously: IBM Promises Commercialization of 50 Qubit Quantum Computers
IBM and D-Wave Quantum Computing Announcements
Intel Ships 17-Qubit Quantum Chip to Researchers
Google's Quantum Computing Plans Threatened by IBM Curveball (doesn't this undermine IBM's quantum system as well?)
Related: Microsoft is Developing a Quantum Computing Programming Language
Cheap Supercomputers: LANL has 750-node Raspberry Pi Development Clusters
One of the more esoteric announcements to come out of SuperComputing 17, an annual conference on high-performance computing, is that one of the largest US scientific institutions is investing in Raspberry Pi-based clusters to aid in development work. The Los Alamos National Laboratory's [LANL] High Performance Computing Division now has access to 750-node Raspberry Pi clusters as part of the first step towards a development program to assist in programming much larger machines.
The platform at LANL leverages a modular cluster design from BitScope Designs, with five rack-mount Bitscope Cluster Modules, each with 150 Raspberry Pi boards with integrated network switches. With each of the 750 chips packing four cores, it offers a 3000-core highly parallelizable platform that emulates an ARM-based supercomputer, allowing researchers to test development code without requiring a power-hungry machine at significant cost to the taxpayer. The full 750-node cluster, running 2-3 W per processor, runs at 1000W idle, 3000W at typical and 4000W at peak (with the switches) and is substantially cheaper, if also computationally a lot slower. After development using the Pi clusters, frameworks can then be ported to the larger scale supercomputers available at LANL, such as Trinity and Crossroads.
Bill Gates is Buying Land in Arizona to Build a "Smart City"
An investment firm run by Bill Gates has put down $80 million to develop a planned community in Arizona. The 25,000 acres of land is about 45 minutes west of Phoenix, in an area called the West Valley. The community, which Gates wants to turn into a "smart city," will be named Belmont.
"Belmont will create a forward-thinking community with a communication and infrastructure spine that embraces cutting-edge technology, designed around high-speed digital networks, data centers, new manufacturing technologies and distribution models, autonomous vehicles and autonomous logistics hubs," Belmont Partners, the Arizona real state investment company involved in the deal, said in a news release.
The proposed freeway I-11, which would connect the Belmont area to Las Vegas, makes the land an ideal spot for a new community, according to Ronald Schott, the executive emeritus at the Arizona Technology Council. Of the 25,000 acres, 3,800 will be used for office, retail, and commercial space. Another 470 acres will be used for public schools. That leaves enough space for 80,000 residential units.
Also at TheUSBPort, Fossbytes, CNET, and Real Estate Daily News.
Homeland Security bulletin warns of weaponized drones and threat to aviation
The Department of Homeland Security (DHS) issued an updated terror bulletin on Thursday highlighting the threat of weaponized drones, chemical attacks and the continued targeting of commercial aircraft.
"We continue to face one of the most challenging threat environments since 9/11, as foreign terrorist organizations exploit the internet to inspire, enable or direct individuals already here in the homeland to commit terrorist acts," reads the bulletin.
[...] "The current bulletin introduces unmanned aircraft systems as potential threats and highlights sustained concern regarding threats against commercial aviation and air cargo," said DHS acting press secretary Tyler Houlton in a statement.
There's been an "uptick in terrorist interest" in using unmanned aerial systems as weapons in the United States and other western countries, according to a senior DHS official. These tactics have been used by terrorists on the battlefield, and the department wants to "guard against those tactics being exported to the west," said the official. The official said that DHS wants to be "forward leaning" about seeing what terrorists are doing overseas and tactics they might adopt in the future.
Since the last bulletin, concerns about terrorist targeting aviation sector have grown, said the official. "[T]errorists continue to target commercial aviation and air cargo, including with concealed explosives," reads the updated bulletin.
Related: UK Criminals Use Drones To Case Burglary Targets
Drones Banned from Flying Within 32 Miles of Super Bowl
FAA Updates its Ban on Drones in Washington
Prison Blames Drone for Inmate's Escape
FAA Restricts Drone Operations Over 10 U.S. Landmarks
A study suggests that the Apple Watch could be used to detect hypertension and sleep apnea in users:
A new study out from health startup Cardiogram and the University of California San Francisco (UCSF) suggests wearables like the Apple Watch, Fitbit and others are able to accurately detect common but serious conditions like hypertension and sleep apnea.
Cardiogram and UCSF previously demonstrated the ability for the Apple Watch to detect abnormal heart rhythm with a 97 percent accuracy. This new study shows the Watch can detect sleep apnea with a 90 percent accuracy and hypertension with an 82 percent accuracy.
Sleep apnea affects an estimated 22 million adults in the U.S., with another 80 percent of cases of moderate and severe obstructive sleep apnea undiagnosed, according to the American Sleep Apnea Association. This is a serious condition where the person affected stops breathing in their sleep and can lead to death.
Another 75 million American adults have high blood pressure (hypertension), according to the Centers for Disease Control (CDC), putting them at risk for heart disease and stroke, the top causes of death in the United States.
Cardiovascular Risk Stratification Using Off-the-Shelf Wearables and a Multi-Task Deep Learning Algorithm (DOI unknown)
Previously: Apple's Watch Can Detect an Abnormal Heart Rhythm With 97% Accuracy, UCSF Study Says
During the game, players have to obtain credits - either by buying them or through long hours of game play - to unlock popular characters including Luke Skywalker and Darth Vader.
Many players said it was unfair as the gaming required worked out at around 40 hours per character, unless they paid.
EA says the number of credits required will now be reduced by 75%.
"Unlocking a hero is a great accomplishment in the game, something we want players to have fun earning," said executive producer John Wasilczyk from the developer Dice, in a statement.
Maybe EA should spend less time withholding heros from players and more time helping players find the hero within.
Elections in 18 separate nations were influenced by online disinformation campaigns last year, suggests research.
Independent watchdog Freedom House looked at how online discourse was influenced by governments, bots and paid opinion formers.
In total, 30 governments were actively engaged in using social media to stifle dissent, said the report.
Educating users to spot fake news and making tech firms police their networks could combat the manipulation, it said.
Hacking must explain why voters are going off-script.
Intel and Micron will produce more 3D XPoint non-volatile memory/storage:
Intel appears confident in the future of its 3D Xpoint media and the Optane products that incorporate it. The company announced today that it's finished an expansion of the facilities at IM Flash in Lehi, Utah (a joint Intel-Micron Technologies venture) that will allow it to produce more of its high-speed, low-latency non-volatile memory. Given the introduction of the Optane SSD 900P series of drives for consumers and the increasing capacities of Optane data-center SSDs, along with the existing Optane Memory line of storage-caching accelerators, Intel will likely have no problem finding homes for the chips it produces with this additional capacity.
The facility also produces 3D NAND.
Also at Digitimes and bit-tech.
Previously: Intel Announces the Optane SSD 900P: Cheaper 3D XPoint for Desktops
Previously graphene-oxide membranes were shown to be completely impermeable to all solvents except for water. However, a study published in Nature Materials, now shows that we can tailor the molecules that pass through these membranes by simply making them ultrathin.
The research team led by Professor Rahul Nair at the National Graphene Institute and School of Chemical Engineering and Analytical Science at The University of Manchester tailored this membrane to allow all solvents to pass through but without compromising it's ability to sieve out the smallest of particles.
In the newly developed ultrathin membranes, graphene-oxide sheets are assembled in such a way that pinholes formed during the assembly are interconnected by graphene nanochannels, which produces an atomic-scale sieve allowing the large flow of solvents through the membrane.
...
Prof. Nair said, "Just for a fun, we even filtered whisky and cognac through the graphene-oxide membrane. The membrane allowed the alcohol to pass through but removed the larger molecules, which gives the amber colour. The clear whisky smells similar to the original whisky but we are not allowed to drink it in the lab, however it was a funny Friday night experiment!"
Minute control over the sheets of graphene allow them to tailor filters for exact purposes like desalinization.
Submitted via IRC for SoyCow1984
A crypto-currency collector who was locked out of his $1m Ethereum multi-signature wallet this week by a catastrophic bug in Parity's software has claimed the blunder was not an accident – it was "deliberate and fraudulent."
On Tuesday, Parity confessed all of its multi-signature Ethereum wallets – which each require multiple people to sign-off transactions – created since July 20 were "accidentally" frozen, quite possibly permanently locking folks out of their cyber-cash collections. The digital money stores contained an estimated $280m of Ethereum; 1 ETH coin is worth about $304 right now. The wallet developer blamed a single user who, apparently, inadvertently triggered a software flaw that brought the shutters down on roughly 70 crypto-purses worldwide.
[...] Cappasity has alleged the wallet freeze was no accident: someone deliberately triggered the mass lock down, we're told, and there's evidence to prove it. By studying devops199's attempts to extract and change ownership of ARToken's and Polkadot's smart contracts, it appears the user was maliciously poking around, eventually triggering the catastrophic bug in Parity's software. "Our internal investigation has demonstrated that the actions on the part of devops199 were deliberate," said Cappasity's founder Kosta Popov in a statement this week.
Source: https://www.theregister.co.uk/2017/11/10/parity_280m_ethereum_wallet_lockdown_hack/
Previously: $300m in Cryptocurrency Accidentally Lost Forever Due to Bug
Air pollution has been linked to weakening of bones:
Poor air quality may be a modifiable risk factor for osteoporosis and bone fractures, especially among people living in low-income communities, according to a newly published analysis of data from two independent studies.
In one study researchers documented higher rates of hospital admissions for bone fractures in communities exposed to elevated levels of ambient particulate matter (PM2·5) air pollution in an analysis of data on more than nine million Medicare enrollees.
In another 8-year follow-up of approximately 700 middle-age, low-income adults participating in a bone health study, participants living in areas with relatively high levels of PM2·5 and black carbon vehicle emissions had lower levels of a key calcium and bone-related hormone and greater decreases in bone mineral density than participants exposed to lower levels of these air pollutants.
All associations were linear and observed -- at least for part of the PM2·5 distribution -- at PM2·5 concentrations below the annual average limits set by the U.S. Environmental Protection Agency (12 μg/m3) and most other industrialized nations.
[...] The researchers acknowledged multiple limitations in both studies, which limit the ability to establish causality. But in an editorial [open, DOI: 10.1016/S2542-5196(17)30143-2] [DX] published with the studies, Tuan Nguyen, PhD, of the Garvan Institute of Medical Research in New South Wales, Australia, wrote that the studies are just the latest in a growing body of research linking air pollution exposure to osteoporosis: "Osteoporosis and its consequence of fragility fracture represent one of the most important public health problems worldwide because fracture is associated with increased mortality."
Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studies (open, DOI: 10.1016/S2542-5196(17)30136-5) (DX)
Related: 80 Percent of World's City Dwellers Breathing Bad Air: UN
Study Links Pregnant Women's Exposure to Air Pollution to Shorter Telomeres in Babies
Lancet Report Says Pollution Caused 9 Million Premature Deaths in 2015